Home Search Reports Help

Gene Model: Gck

NomenclatureGenomic Location
SymbolGckChromosomeX
NameGlucokinaseLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesX: 67 Mbp

Molecular Function

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Molecular Function Terms:

binding
   carbohydrate binding
      sugar binding
         monosaccharide binding
            glucose binding
   ion binding
      cation binding
         metal ion binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ADP binding
               ATP binding
   protein binding
      enzyme binding
         phosphatase binding
            protein phosphatase binding

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         phosphotransferase activity, alcohol group as acceptor
            kinase activity
               hexokinase activity

Human Disease Association

Defects in GCK are the cause of maturity-onset diabetes of the young type 2 (MODY2) [MIM:125851]; also shortened MODY-2. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.

Defects in GCK are the cause of familial hyperinsulinemic hypoglycemia type 3 (HHF3) [MIM:602485]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.

Predicted Transcript
     1 ATGCTGGATCACAGAGCTAGGATGGACAGCTCCAAGAAGGAGAAGGTGGAACAAATCTTG
    61 TCAGAATTCCAGCTACGAGAAGAGGATCTGAAAAAGGTGATGCGCCGGATGCAAAAGGAA
   121 ATGGACCGAGGGCTAAAGCTAGAGACTCACCAAGAAGCCTCTGTAAAGATGCTGCCCACT
   181 TACGTGCGCTCTACTCCTGAGGGATCAGCTGCAGAGGTTGGAGATTTTCTATCTTTGGAT
   241 CTTGGGGGAACCAATTTTCGAGTTATGCTGGTAAAAGTGGGCGAAGGTGAAGAAGGACAG
   301 TGGACTGTGAAGACAAAGCACCAGATGTATTCAATCCCAGAAGATGCCATGACAGGAACA
   361 GCTGAAATGCTCTTCGATTATATCTCAGAATGCATCTCTGACTTCTTAGACAAACATCAG
   421 ATGAAACACAAAAAGCTACCTCTGGGTTTCACATTTTCCTTCCCTGTACGGCATGAAGAC
   481 ATTGACAAGGGGATCCTACTGAACTGGACTAAAGGTTTCAAAGCATCAGGCGCAGAAGGG
   541 AACAATGTTGTGGGGCTTCTGAGAGATGCTATTAAACGGCGAGGGGACTTTGAGATGGAT
   601 GTGGTTGCAATGGTCAATGACACAGTGGCAACAATGATATCCTGCTACTATGAGGATCAC
   661 CGATGTGAAGTTGGCATGATAGTGGGCACAGGTTGCAATGCTTGTTACATGGAGGAGATG
   721 CAGAATGTTGAGCTGGTGGAAGGGAATGAAGGTCGAATGTGTGTCAACACTGAATGGGGA
   781 GCCTTTGGGGCATCCGGAGAACTGGATGAGTTCCTCTTGGAGTATGATCATGTGGTGGAT
   841 GAGACCTCGCTTAACCCCGGTCAGCAGCTGTATGAGAAGATTATAGGAGGGAAGTACATG
   901 GGTGAAATTGCACGACTAGTTCTGCTAAAACTTGTTAATGAAAATTTGCTCTTCAATGGA
   961 GAAGCTTCAGAGAAGCTGAAAACCAGAGGGTCATTTGAAACACGTTTAATTTCCCAAGTT
  1021 GAAAGTGATCCTGGTGACCGTAAGCAGATCTACAACATTCTGACATCCTTTGGGCTTTTG
  1081 CCCTCAGCAACAGACTGTGACATTGTTCGTATGGTATGTGAGAGAGTTTCAACACGGGCT
  1141 GCACAGATGTGTTCAGCAGGGCTGGCTGGTGTCATCAACCGGATGAGAGACAGCAGAAGT
  1201 GAGGAGACACTAAAGATCACTGTAGGCGTGGATGGTTCAGTCTACAAGCTCCATCCCAGC
  1261 TTCAAAGACCGATTCCATACAACAGTCCGACAACTGACACCAGGCTGCGACATCACATTC
  1321 CTGCAGTCGGAGGAAGGCAGTGGCAGAGGGGCCGCTCTCATCTCTGCAGTAGCATGCAAA
  1381 ATGGCCTGCATGATCAGCCAGTGA

Predicted Protein Product
MLDHRARMDSSKKEKVEQILSEFQLREEDLKKVMRRMQKEMDRGLKLETHQEASVKMLPT
YVRSTPEGSAAEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWTVKTKHQMYSIPEDAMTGT
AEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEG
NNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEM
QNVELVEGNEGRMCVNTEWGAFGASGELDEFLLEYDHVVDETSLNPGQQLYEKIIGGKYM
GEIARLVLLKLVNENLLFNGEASEKLKTRGSFETRLISQVESDPGDRKQIYNILTSFGLL
PSATDCDIVRMVCERVSTRAAQMCSAGLAGVINRMRDSRSEETLKITVGVDGSVYKLHPS
FKDRFHTTVRQLTPGCDITFLQSEEGSGRGAALISAVACKMACMISQ
Protein Alignment to Mouse
sp|P52792|HXK4_MOUSE Glucokinase OS=Mus musculus GN=Gck PE=2 SV=1
      MGI:1270854 Gck glucokinase (Chr 11)
        Length = 465

 Score = 2094 (742.2 bits), Expect = 1.9e-217, P = 1.9e-217
 Identities = 397/467 (85%), Positives = 430/467 (92%)

Query:     1 MLDHRARMDSSKKEKVEQILSEFQLREEDLKKVMRRMQKEMDRGLKLETHQEASVKMLPT 60
             MLD RARM+++KKEKVEQIL+EFQL+EEDLKKVM RMQKEMDRGLKLETHQEASVKMLPT
Sbjct:     1 MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPT 60

Query:    61 YVRSTPEGSAAEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWTVKTKHQMYSIPEDAMTGT 120
             YVRSTPEGS  EVGDFLSLDLGGTNFRVMLVKVGEGE GQW+VKTKHQMYSIPEDAMTGT
Sbjct:    61 YVRSTPEGS--EVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGT 118

Query:   121 AEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEG 180
             AEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEG
Sbjct:   119 AEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEG 178

Query:   181 NNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHRCEVGMIVGTGCNACYMEEM 240
             NN+VGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYED +CEVGMIVGTGCNACYMEEM
Sbjct:   179 NNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEM 238

Query:   241 QNVELVEGNEGRMCVNTEWGAFGASGELDEFLLEYDHVVDETSLNPGQQLYEKIIGGKYM 300
             QNVELVEG+EGRMCVNTEWGAFG SGELDEFLLEYD +VDE+S+NPGQQLYEKIIGGKYM
Sbjct:   239 QNVELVEGDEGRMCVNTEWGAFGNSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYM 298

Query:   301 GEIARXXXXXXXXXXXXFNGEASEKLKTRGSFETRLISQVESDPGDRKQIYNILTSFGLL 360
             GE+ R            F+GEASE+L+TRG+FETR +SQVESD GDR+QI NIL++ GL 
Sbjct:   299 GELVRLVLLKLVEENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRRQILNILSTLGLR 358

Query:   361 PSATDCDIVRMVCERVSTRAAQMCSAGLAGVINRMRDSRSEETLKITVGVDGSVYKLHPS 420
             PS  DCDIVR  CE VSTRAA MCSAGLAGVINRMR+SRSE+ ++ITVGVDGSVYKLHPS
Sbjct:   359 PSVADCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPS 418

Query:   421 FKDRFHTTVRQLTPGCDITFLQSEEGSGRGAALISAVACKMACMISQ 467
             FK+RFH +VR+LTP C+ITF++SEEGSGRGAAL+SAVACK ACM+ Q
Sbjct:   419 FKERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLGQ 465