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Gene Model: Pkm2

NomenclatureGenomic Location
SymbolPkm2Chromosome1
NamePyruvate kinase isozymes M1/M2Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates1: 48 Mbp

Molecular Function

Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

ATP + pyruvate = ADP + phosphoenolpyruvate.

Molecular Function Terms:

binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ADP binding
   protein binding

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         kinase activity
            pyruvate kinase activity

Human Disease Association

Predicted Transcript
     1 GCCCCAGAAGCCATGTCTAAGGAACACGATGCCTTTATCCAGACCCAGCAGCTGCATGCT
    61 GCCTTTGCAGACACATTCCTGGAACACATGTGCCGCCTGGACATTGATTCTCCCCCAATC
   121 ACTGCCAGAAACACTGGCATCATCTGCACAATTGGCCCGGCTTCCCGGTCAATTGAAATG
   181 CTGAGAGAAATGATTAAATCTGGAATGAATGTTGCCCGTCTCAACTTCTCTCATGGAACT
   241 CATGAGTACCATGCAGGAACAATCAAGAATGTACGAGAAGCTACTGAGAGCTTTGCTTCT
   301 GATCCAATTTCATACAGACCTGTTGCTATTGCACTGGATACTAAGGGACCTGAAATCAGA
   361 ACTGGACTCATCAAGGGAAGTGGTACAGCAGAAGTGGAGCTCAAGAAGGGTGCAACTCTG
   421 AAACTTACTCTGGATAATGCTTTCATGGAGAACTGTGACGAAAATGTCCTGTGGGTGGAC
   481 TACAAAAATATTACCAAAGTTGTGGAGATTGGCAGCAAAATCTATGTGGATGATGGTCTT
   541 ATTTCCCTGCAGGTTAAGGAAAAAGGTGCTGACTTCCTCATCACAGAAATTGAAAATGGT
   601 GGTATGTTAGGCAGCAAGAAGGGTATAAACCTGCCAGGTGCTGCAGTAGACCTTCCAGCT
   661 GTTTCTGAAAAGGACATCCAGGATCTGCAATTTGGCGTGGAGCAGGGTGTCGACATGGTG
   721 TTTGCATCCTTCATCCGCAAGGCAGCTGATGTTCATGCTGTCAGGAAGGTGCTGGGGGAA
   781 AAGGGAAAGAACATCAAGATCATTAGCAAGATTGAAAACCATGAGGGAGTACGCAGATTT
   841 GATGAGGTTATGGAGGCTAGTGATGGCATCATGGTAGCTCGTGGTGACCTTGGTATTGAG
   901 ATTCCTACTGAAAAGGTCTTCCTTGCCCAGAAAATGATGATTGGTCGATGCAACAGAGCT
   961 GGCAAGCCAATCATTTGTGCTACTCAGATGCTGGAGAGCATGATTAAGAAGCCACGCCCA
  1021 ACACGGGCTGAGGGGAGTGATGTGGCTAATGCTGTTTTGGATGGAGCTGACTGTATCATG
  1081 CTCTCCGGAGAGACCGCCAAAGGAGACTATCCACTGGAGGCTGTTCGGATGCAGCATCTT
  1141 ATTGCTCGGGAGGCTGAGGCTGCAATCTATCACCGCCAGCTGTTTGAAGAACTTTTCCGC
  1201 CTCACTGTTAACAACAGGGACCCTCTTGATGCCATTGCTGTAGGCGCTGTGGAGGCCTCT
  1261 TTTAAGTGCTTAGCTGCAGCTGTGATAGTTTTGACAGAGTCCGGCAGGTCTGCTCACTTG
  1321 GTATCGAGATACCGCCCCCGTGCTCCCATTATTGCTGTGACCCGTGATGCTCAGACAGCC
  1381 CGCCAGGCCCACCTCTATCGTGGCATTTTCCCTGTGCTATGCAAGGAGCCAACACACGAC
  1441 TCCTGGGCTGAGGATGTTGATCTACGAGTGAATATGGGCATGGATGTTGGCAAAGCTCGT
  1501 GGGTTCTTCAAGCCTGGTGACCTGGTCATCGTGCTTACAGGGTGGCGCCCAGGCTCTGGC
  1561 TACACCAACACCATGCGAGTGGTGCCCGTCCCATAA

Predicted Protein Product
APEAMSKEHDAFIQTQQLHAAFADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSIEM
LREMIKSGMNVARLNFSHGTHEYHAGTIKNVREATESFASDPISYRPVAIALDTKGPEIR
TGLIKGSGTAEVELKKGATLKLTLDNAFMENCDENVLWVDYKNITKVVEIGSKIYVDDGL
ISLQVKEKGADFLITEIENGGMLGSKKGINLPGAAVDLPAVSEKDIQDLQFGVEQGVDMV
FASFIRKAADVHAVRKVLGEKGKNIKIISKIENHEGVRRFDEVMEASDGIMVARGDLGIE
IPTEKVFLAQKMMIGRCNRAGKPIICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHRQLFEELFRLTVNNRDPLDAIAVGAVEAS
FKCLAAAVIVLTESGRSAHLVSRYRPRAPIIAVTRDAQTARQAHLYRGIFPVLCKEPTHD
SWAEDVDLRVNMGMDVGKARGFFKPGDLVIVLTGWRPGSGYTNTMRVVPVP
Protein Alignment to Mouse
sp|P52480|KPYM_MOUSE Pyruvate kinase isozymes M1/M2 OS=Mus musculus GN=Pkm2
            PE=1 SV=4
      MGI:97591 Pkm2 pyruvate kinase, muscle (Chr 9)
        Length = 531

 Score = 2421 (857.3 bits), Expect = 4.3e-252, P = 4.3e-252
 Identities = 468/530 (88%), Positives = 497/530 (93%)

Query:     2 PEAMSKEHDAFIQTQQLHAAFADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSIEML 61
             P+  S+   AFIQTQQLHAA ADTFLEHMCRLDIDS PITARNTGIICTIGPASRS+EML
Sbjct:     2 PKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEML 61

Query:    62 REMIKSGMNVARLNFSHGTHEYHAGTIKNVREATESFASDPISYRPVAIALDTKGPEIRT 121
             +EMIKSGMNVARLNFSHGTHEYHA TIKNVREATESFASDPI YRPVA+ALDTKGPEIRT
Sbjct:    62 KEMIKSGMNVARLNFSHGTHEYHAETIKNVREATESFASDPILYRPVAVALDTKGPEIRT 121

Query:   122 GLIKGSGTAEVELKKGATLKLTLDNAFMENCDENVLWVDYKNITKVVEIGSKIYVDDGLI 181
             GLIKGSGTAEVELKKGATLK+TLDNA+ME CDEN+LW+DYKNI KVVE+GSKIYVDDGLI
Sbjct:   122 GLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLI 181

Query:   182 SLQVKEKGADFLITEIENGGMLGSKKGINLPGAAVDLPAVSEKDIQDLQFGVEQGVDMVF 241
             SLQVKEKGADFL+TE+ENGG LGSKKG+NLPGAAVDLPAVSEKDIQDL+FGVEQ VDMVF
Sbjct:   182 SLQVKEKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVF 241

Query:   242 ASFIRKAADVHAVRKVLGEKGKNIKIISKIENHEGVRRFDEVMEASDGIMVARGDLGIEI 301
             ASFIRKAADVH VRKVLGEKGKNIKIISKIENHEGVRRFDE++EASDGIMVARGDLGIEI
Sbjct:   242 ASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEI 301

Query:   302 PTEKVFLAQKMMIGRCNRAGKPIICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 361
             P EKVFLAQKMMIGRCNRAGKP+ICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML
Sbjct:   302 PAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIML 361

Query:   362 SGETAKGDYPLEAVRMQHLIAREAEAAIYHRQLFEELFRLTVNNRDPLDAIAVGAVEASF 421
             SGETAKGDYPLEAVRMQHLIAREAEAAIYH QLFEEL RL     DP +A AVGAVEASF
Sbjct:   362 SGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASF 421

Query:   422 KCLAAAVIVLTESGRSAHLVSRYRPRAPIIAVTRDAQTARQAHLYRGIFPVLCKEPTHDS 481
             KC + A+IVLT+SGRSAH V+RYRPRAPIIAVTR+ QTARQAHLYRGIFPVLCK+   ++
Sbjct:   422 KCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNA 481

Query:   482 WAEDVDLRVNMGMDVGKARGFFKPGDLVIVLTGWRPGSGYTNTMRVVPVP 531
             WAEDVDLRVN+ MDVGKARGFFK GD+VIVLTGWRPGSG+TNTMRVVPVP
Sbjct:   482 WAEDVDLRVNLAMDVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 531