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Gene Model: Tph2

NomenclatureGenomic Location
SymbolTph2Chromosome1
NameTryptophan 5-hydroxylase 2Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates1: 43 Mbp

Molecular Function

L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.

Molecular Function Terms:

binding
   amine binding
      amino acid binding
   ion binding
      cation binding
         metal ion binding

catalytic activity
   oxidoreductase activity
      monooxygenase activity

Human Disease Association

Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].

Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.

Predicted Transcript
     1 ATGCAACCCGCAATGATGATGTTCTCCAGCAAATACTGGGCAAGACGGGGCCTTTCTCTG
    61 GACTCCGCTGTGCCCCTGGAGCATCCACTACATGGCAACCTGACTCAAAACAGAACCAAT
   121 TCTGGTAAAAATGATGACAAAAAGGGTAATAAAGGTGCAGGCAAGTATGAATCAACGTCA
   181 GAAGGTGGCAAGACTGCGGTGGTGTTTTCTTTGAAAAATGAAGTTGGTGGCTTGGTAAAA
   241 GCTCTCAGACTTTTCCAGGAAAAGCATGTGAGTATGGTTCATATTGAATCAAGAAAATCA
   301 AAGAGAAGGAGTTCAGAAGTGGAAATCTTTGTGGATTGTGACTGCAGCAAGAAACAATTC
   361 AACGAGCTTATTCAGTTGTTAAAGTATGAAACAAACATTGTCACTCTGAACCCTCCGGAA
   421 AACATCTGGACTGATGAGGAAGAGCTTGACTGTGTTCCTTGGTTCCCCAGGAAGATTGCC
   481 GAATTAGACAAATGCTCCCAAAGAGTTTTAATGTATGGCTCTGAACTGGATGCAGACCAC
   541 CCTGGATTTAAGGACAACGTCTATCGGCAGAGAAGAAAATATTTTGTAGATGTTGCCATG
   601 AATTATAAATATGGCCAGCCAATTCCTAGATTGGACTATACCCCAGAAGAAATAAAAACA
   661 TGGGGCGTTGTGTTCAGGGAACTCACCAAACTCTACCCGACTCATGCATGTCGAGAGTAC
   721 TTGAAAAACTTCCCTTTGCTGACAAAGCATTGTGGCTACAGAGAGGATAATGTCCCTCAA
   781 CTGGAGGATGTTGCTGTGTTTCTTAAAGAAAGGTCTGGCTTTACAGTCAGACCGGTTGCT
   841 GGATATTTGTCACCTCGGGATTTCTTAGCAGGCCTTGCTTATCGGGTTTTCCACTGTACC
   901 CAGTACATACGCCATGGCTCTGACCCCCTCTACACTCCTGAACCCGATACATGCCATGAA
   961 CTCCTGGGACATGTGCCTCTGCTTGCCGATCCTAAATTTGCCCAGTTTTCCCAAGAGATT
  1021 GGATTGGCCTCCCTGGGAGCATCTGACGAAGATGTCCAAAAACTTGCCACTTGCTATTTT
  1081 TTTACCATTGAATTTGGCCTTTGCAAGCAAGAGGGACAATTACGAGCTTATGGAGCAGGT
  1141 CTTCTATCTTCCATTGGAGAGCTCAAGCATGCTCTGTCTGATAAAGCTAATGTGAAAACG
  1201 TTTGATCCAAAGACAACCTGCTTGCAAGAATGCCTTATCACAACTTTCCAGGAAGCTTAC
  1261 TTTGTCTCAGAAAGTTTTGAAGAAGCCAAAGAGAAGATGAGGGACTTTGCAAAATCGATC
  1321 AACCGCCCCTTTTCTGTGTATTTCAATCCCTATACCCAGAGCATAGAAATTCTGAAAGAT
  1381 ACTAGAAGTATCGAAAATGTTGTCCAGGATCTTCGCAGTGACTTGAACACAGTGTGTGAT
  1441 GCTTTAAGCAAAATGAACAGATACTTGGGCATATGA

Predicted Protein Product
MQPAMMMFSSKYWARRGLSLDSAVPLEHPLHGNLTQNRTNSGKNDDKKGNKGAGKYESTS
EGGKTAVVFSLKNEVGGLVKALRLFQEKHVSMVHIESRKSKRRSSEVEIFVDCDCSKKQF
NELIQLLKYETNIVTLNPPENIWTDEEELDCVPWFPRKIAELDKCSQRVLMYGSELDADH
PGFKDNVYRQRRKYFVDVAMNYKYGQPIPRLDYTPEEIKTWGVVFRELTKLYPTHACREY
LKNFPLLTKHCGYREDNVPQLEDVAVFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCT
QYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYF
FTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKANVKTFDPKTTCLQECLITTFQEAY
FVSESFEEAKEKMRDFAKSINRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCD
ALSKMNRYLGI
Protein Alignment to Mouse
sp|Q8CGV2|TPH2_MOUSE Tryptophan 5-hydroxylase 2 OS=Mus musculus GN=Tph2 PE=2
            SV=2
      MGI:2651811 Tph2 tryptophan hydroxylase 2 (Chr 10)
        Length = 488

 Score = 2210 (783.0 bits), Expect = 9.7e-230, P = 9.7e-230
 Identities = 417/491 (84%), Positives = 446/491 (90%)

Query:     1 MQPAMMMFSSKYWARRGLSLDSAVPLEHPLHGNLTQNRTNSXXXXXXXXXXXXXXYESTS 60
             MQPAMMMFSSKYWARRGLSLDSAVP +H L G+LTQN+                    T+
Sbjct:     1 MQPAMMMFSSKYWARRGLSLDSAVPEDHQLLGSLTQNKAIKSEDKKSGKEPGKG---DTT 57

Query:    61 EGGKTAVVFSLKNEVGGLVKALRLFQEKHVSMVHIEXXXXXXXXXEVEIFVDCDCSKKQF 120
             E  KTAVVFSLKNEVGGLVKALRLFQEKHV+M+HIE         EVEIFVDC+C K +F
Sbjct:    58 ESSKTAVVFSLKNEVGGLVKALRLFQEKHVNMLHIESRRSRRRSSEVEIFVDCECGKTEF 117

Query:   121 NELIQLLKYETNIVTLNPPENIWTDEEELDCVPWFPRKIAELDKCSQRVLMYGSELDADH 180
             NELIQLLK++T IVTLNPPE+IWT+EE+L+ VPWFPRKI+ELD+CS RVLMYG+ELDADH
Sbjct:   118 NELIQLLKFQTTIVTLNPPESIWTEEEDLEDVPWFPRKISELDRCSHRVLMYGTELDADH 177

Query:   181 PGFKDNVYRQRRKYFVDVAMNYKYGQPIPRLDYTPEEIKTWGVVFRELTKLYPTHACREY 240
             PGFKDNVYRQRRKYFVDVAM YKYGQPIPR++YT EE KTWGVVFREL+KLYPTHACREY
Sbjct:   178 PGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREY 237

Query:   241 LKNFPLLTKHCGYREDNVPQLEDVAVFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCT 300
             LKN PLLTK+CGYREDNVPQLEDV++FLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCT
Sbjct:   238 LKNLPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCT 297

Query:   301 QYIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYF 360
             QY+RHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYF
Sbjct:   298 QYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYF 357

Query:   361 FTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKANVKTFDPKTTCLQECLITTFQEAY 420
             FTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKA VK+FDPKTTCLQECLITTFQ+AY
Sbjct:   358 FTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKSFDPKTTCLQECLITTFQDAY 417

Query:   421 FVSESFEEAKEKMRDFAKSINRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCD 480
             FVS+SFEEAKEKMRDFAKSI RPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCD
Sbjct:   418 FVSDSFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCD 477

Query:   481 ALSKMNRYLGI 491
             AL+KMN+YLGI
Sbjct:   478 ALNKMNQYLGI 488