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Gene Model: Hacl1

NomenclatureGenomic Location
SymbolHacl1Chromosome2
Name2-Hydroxyacyl-CoA lyase 1Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates2: 94 Mbp

Molecular Function

Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.

Molecular Function Terms:

binding
   cofactor binding
      coenzyme binding
         thiamine pyrophosphate binding
   protein binding
      identical protein binding
   vitamin binding
      thiamine pyrophosphate binding

catalytic activity
   lyase activity
      carbon-carbon lyase activity

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGGCTCCGCCAAGTCCGCGAGAGGAGGAAGAAAGCGAACGTATCACTGGGGCTCAAGTC
    61 ATTGCGGAGGCCCTCAAGAAGCAAAATGTTGAATACATGTTTGGTATTGTTGGCATTCCC
   121 GTGATTGAAGTTGCAGTTGCCGCTCAAGCAAGTGGAATTAAATATATAGGGATGCGGAAT
   181 GAACAAGCTGCCTCCTATGCTGCTTCTGCTATTGGGTACCTGACGGGCAGGCCTGGTGTA
   241 TGCCTTGTAGTTTCTGGTCCTGGCCTTATCCATGCACTAGCTGGAATGGCAAATGCAAAT
   301 ATGAATTGCTGGCCTTTGATTGTCATAGGAGGTTCCTCTGACAGAAATCAGGAAACAATG
   361 GGAGCTTTCCAGGAATTTCCACAGGTTGAAGCCTGTAGGTTATACAGCAAATTTAGCGCC
   421 AGACCAACCAGCTTAGAAGCAATTCCTGCTGTTATTGAGAAGGCTGTCAGAACCAGTATT
   481 TACGGCCGTCCAGGAGCTTGCTATATTGACATACCTGGAGACTTTGTAAATCTGGAGGTG
   541 AACAAAAGTTCTGTCAAATATGTAGATTGTTGTCCAGAACCTCCCATCAGTATGGCTGAA
   601 GACGCAGCCATTTCCAAAGCTGCATCATTCATTGCACATTCCAGAAAACCACTAGTTATT
   661 ATTGGAAAAGGTGCTGCTTACTCACATGCTGAAAATAGCATCAGAAAGTTGGTGGACCAA
   721 TGCGGGCTTCCTTTTTTGCCTACCCCGATGGGAAAGGGAGTTGTTCCTGACAACCATCCA
   781 CACTGTGTAGCTGCAGCCAGATCTAGAACAAATAGGGCACTGCTGCATGCTGATGTGATC
   841 CTATTACTTGGTGCTAGACTGAACTGGATTCTACACTTTGGACTTCCACCAAGATTTCAG
   901 CCAGATGTAAAAATAATCCAGGTAGACATTTGTGCAGAAGAATTAGGAAACAACGTGAAA
   961 CCCGTTGTAGCCTTATTGGGTGACATAAAAGCAGTGACGGAGCAGCTTCTAGATCAGCTG
  1021 AACAAAAAGCATTGGAAATACCCTTCTGATACAGAGTGGTGGAAAGATCTACAGGCGAAA
  1081 ATTCAAAGCAATGAACAGACATCCAAGGCACTATCACTGCAGAAAACTCTGCCAATGAAT
  1141 TATTATACAGTATTCCACTGTATCAGGGAGCATTTGCCAAAGGACTGCCTTCTCATTAGT
  1201 GAGGGAGCAAACACAATGGACATAGGACGCACCATGCTTCCTAACTATTATCCCCGCCTC
  1261 AGGCTTGATGCTGGTACCTTTGGAACAATGGGGGTTGGACTGGGTTTTGCATTAGCAGCT
  1321 GCTATGGTTACTAAAGATCATAATCCTGAGCAGCAAGTGGTCTGCATAGAAGGGGACAGC
  1381 GCCTTTGGCTTCTCTGGCATGGAAGTGGAGACTATGTGCAGGTATAACTTGCCAATCGTT
  1441 GTAATCATAGTAAACAACAATGGGATATACAGTGGCCTGGATGCAGAGACTTGGAAAGAG
  1501 ATGTTGAAACTTGGAGAACCTTCTGCATGTGTTCCTCCCATTTCTCTGTTGCCAAATGCT
  1561 CACTATGAGCAAATTGTGTCTGCATTTGGTGGGAAAGGCTATTTTGTACAAACACCAGAA
  1621 GAACTCCAAGCTGCCTTGAAGAAAAGTCTTGCTGAAAAACATGTGCCTTCCCTCATTAAT
  1681 GTAATGATTGATCCACAATCAGATAGAAAGAAACAAGATTTTCATTGGCTGACCCGCTCT
  1741 AACATGTAG

Predicted Protein Product
MAPPSPREEEESERITGAQVIAEALKKQNVEYMFGIVGIPVIEVAVAAQASGIKYIGMRN
EQAASYAASAIGYLTGRPGVCLVVSGPGLIHALAGMANANMNCWPLIVIGGSSDRNQETM
GAFQEFPQVEACRLYSKFSARPTSLEAIPAVIEKAVRTSIYGRPGACYIDIPGDFVNLEV
NKSSVKYVDCCPEPPISMAEDAAISKAASFIAHSRKPLVIIGKGAAYSHAENSIRKLVDQ
CGLPFLPTPMGKGVVPDNHPHCVAAARSRTNRALLHADVILLLGARLNWILHFGLPPRFQ
PDVKIIQVDICAEELGNNVKPVVALLGDIKAVTEQLLDQLNKKHWKYPSDTEWWKDLQAK
IQSNEQTSKALSLQKTLPMNYYTVFHCIREHLPKDCLLISEGANTMDIGRTMLPNYYPRL
RLDAGTFGTMGVGLGFALAAAMVTKDHNPEQQVVCIEGDSAFGFSGMEVETMCRYNLPIV
VIIVNNNGIYSGLDAETWKEMLKLGEPSACVPPISLLPNAHYEQIVSAFGGKGYFVQTPE
ELQAALKKSLAEKHVPSLINVMIDPQSDRKKQDFHWLTRSNM
Protein Alignment to Mouse
sp|Q9QXE0|HACL1_MOUSE 2-hydroxyacyl-CoA lyase 1 OS=Mus musculus GN=Hacl1 PE=1
            SV=2
      MGI:1929657 Hacl1 2-hydroxyacyl-CoA lyase 1 (Chr 14)
        Length = 581

 Score = 2204 (780.9 bits), Expect = 4.2e-229, P = 4.2e-229
 Identities = 406/568 (71%), Positives = 485/568 (85%)

Query:    15 ITGAQVIAEALKKQNVEYMFGIVGIPVIEVAVAAQASGIKYIGMRNEQAASYAASAIGYL 74
             ++GA+VIA+ALK Q+VEYMFG+VGIPV E+A+AAQ  GIKYIGMRNEQAA YAASA+GYL
Sbjct:    17 VSGAKVIAQALKTQDVEYMFGVVGIPVTEIALAAQELGIKYIGMRNEQAACYAASAVGYL 76

Query:    75 TGRPGVCLVVSGPGLIHALAGMANANMNCWPLIVIGGSSDRNQETMGAFQEFPQVEACRL 134
             TGRPGVCLVVSGPGLIHAL GMANANMNCWPLIVIGGSS+RNQE MGAFQEFPQVEACRL
Sbjct:    77 TGRPGVCLVVSGPGLIHALGGMANANMNCWPLIVIGGSSERNQEAMGAFQEFPQVEACRL 136

Query:   135 YSKFSARPTSLEAIPAVIEKAVRTSIYGRPGACYIDIPGDFVNLEVNKSSVKYVDCCPEP 194
             Y+KFSARP+++E IP +IEKAVR+SIYGRPGACYIDIP DFV L+ N +S+KY +CC  P
Sbjct:   137 YTKFSARPSTIELIPFIIEKAVRSSIYGRPGACYIDIPADFVTLQANVTSIKYKECCMPP 196

Query:   195 PISMAEDAAISKAASFIAHSRKPLVIIGKGAAYSHAENSIRKLVDQCGLPFLPTPMGKGV 254
             P+SMAE +A+  AAS +  +++PL+IIGKGAAYSHAE+SIRKLV+QC LPFLPTPMGKGV
Sbjct:   197 PVSMAETSAVCAAASVLRDAKQPLLIIGKGAAYSHAEDSIRKLVEQCSLPFLPTPMGKGV 256

Query:   255 VPDNHPHCVAAARSRTNRALLHADVILLLGARLNWILHFGLPPRFQPDVKIIQVDICAEE 314
             VPDNHP+CV AARSR   AL  ADVI+L GARLNWILHFGLPPR+Q DVK IQ+DICAEE
Sbjct:   257 VPDNHPNCVGAARSR---ALQSADVIVLFGARLNWILHFGLPPRYQADVKFIQIDICAEE 313

Query:   315 LGNNVKPVVALLGDIKAVTEQLLDQLNKKHWKYPSDTEWWKDLQAKIQSNEQTSKALSLQ 374
             LGNNV+P V LLGDI AV++QLL+Q +K  W+ P D++WWK L+ K++SNE  SK L+ Q
Sbjct:   314 LGNNVRPSVILLGDIDAVSKQLLEQFDKTPWQCPPDSQWWKTLREKMKSNEAISKELASQ 373

Query:   375 KTLPMNYYTVFHCIREHLPKDCLLISEGANTMDIGRTMLPNYYPRLRLDAGTFGTMGVGL 434
             K+LPMNYYTVF+ ++E LP+D  ++SEGANTMDIGRTML N  PR RLDAG+FGTMGVGL
Sbjct:   374 KSLPMNYYTVFYHVQEQLPRDSFIVSEGANTMDIGRTMLQNCLPRHRLDAGSFGTMGVGL 433

Query:   435 GFALAAAMVTKDHNPEQQVVCIEGDSAFGFSGMEVETMCRYNLPXXXXXXXXXGIYSGLD 494
             GFA+AAA+V KD +P Q+V+C+EGDSAFGFSGMEVET+CRYNLP         GIY G D
Sbjct:   434 GFAIAAALVAKDRSPGQRVICVEGDSAFGFSGMEVETICRYNLPIILLVVNNNGIYQGFD 493

Query:   495 AETWKEMLKLGEPSACVPPISLLPNAHYEQIVSAFGGKGYFVQTPEELQAALKKSLAEKH 554
             A+TW++ML   E +  VPP+ LLPN+HYEQ+++AFGGKGYFV+TPEELQ +L+++L +  
Sbjct:   494 ADTWEKMLHFQEAATTVPPMCLLPNSHYEQVMTAFGGKGYFVRTPEELQHSLRQALQDTS 553

Query:   555 VPSLINVMIDPQSDRKKQDFHWLTRSNM 582
              P L+N+MI+PQS RK QDFHWLTRSNM
Sbjct:   554 KPCLLNIMIEPQSTRKAQDFHWLTRSNM 581