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Gene Model: Nox4

NomenclatureGenomic Location
SymbolNox4ChromosomeX
NameNADPH oxidase 4Linkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesX: 61 Mbp

Molecular Function

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation.

Molecular Function Terms:

binding
   cofactor binding
      coenzyme binding
         flavin adenine dinucleotide binding
   ion binding
      cation binding
         metal ion binding

catalytic activity
   oxidoreductase activity
      oxidoreductase activity, acting on NADH or NADPH
         oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
            NAD(P)H oxidase activity
            superoxide-generating NADPH oxidase activity

electron carrier activity

Human Disease Association

No disease association.

Predicted Transcript
     1 CAGCTAGGATTGTGCGTCAGTAGAGCTTCTGCATCCATCCTTAACCTCAACTGCAGCCTG
    61 GTTCTGTTACCTGTGTGCCGGATTCTTCTTGCCTTCCTTCGAGGTTCTCAGAAGGTGCCC
   121 AGCCGAAAAACTAGAAGGCTGCTGGATAAAAGCAAAACTTTCCATGTGACGTGTGGTGTG
   181 ATGATCTGTATCTTCTCAGTGATTCATGTTGGTGCTCACCTGGTGAACGCATTAAACTTC
   241 TCTGTGAACTACAGTGAACAGTTTCTTGCCCTCAACGTAGCCAACTACCGTGGTGAGGAT
   301 CCCAGGAAACTCCTTTTTACAACAGTTCCTGGATTAACTGGAGTCCTTATGGTGCTGGTG
   361 TTATTCTTGATGTCTACAGCTTCTACTTATGCCATTCGGGTTTCAAATTATGACATCTTT
   421 TGGTATACCCACAACCTCTTCTTTGTCTTCTACTTGCTGCTGATGTTGCATGTTTCTGGG
   481 GGAGTTCTGAAATACCAAACCAACGTAAAAGAGCACCCCCCGGGGTGCTTTAATCCTAAC
   541 AGGACCATTCAAGAAGGGAGAGACTTTGAGAAGTCCCACCCTGAAAATGCTTGGGAACCT
   601 TTTCCTCGCCGTTTAGTGGAAATGGAGCCTCTTCTCAAAAGCAACATTGTCTGTATAGAG
   661 GAGCCTAAATTCCAAGCCCATTTCCCAGAGACTTGGCTTTGGATCTCTGGCCCATTGTGT
   721 TTGTATTGCGCAGAAAGGCTGTACCGATACATCTGTAGCAGCAATAAACCTGTCACAATC
   781 ACTGCAGTGATCAGCCATGCTTGTGATGTCCTTGAGGTACGGATGATGAAGGAGGACTTC
   841 AGAGCCAGACCTGGACAGTATGTCATTCTGCACTGTCCTGGTGTGTCATCTGTGGAAAGC
   901 CATCCCTTTACTCTAACACTGTGTCCGACAGCTACCAAAGCAACCTTTGGAGTCCACGTT
   961 AAAGTCGTAGGAGACTGGACCGAGAGATTTCGGGATCTACTCTTTCTACATTCCAGCTTG
  1021 GATGCTGAGTTTCTGCCAGTCTTCCAGCAGAGGCATTACCCAAAGTTGTACGTAGACGGT
  1081 CCCTTTGGCAGCCCCTTTGAGGAATCCTTCAATTATGAGGTTAGCCTCTGTGTGGCTGGA
  1141 GGCATTGGAGTGACTCCGTTCGCATCGATCCTCAACACCCTGCTGGATGAGTGGGAATGC
  1201 TACAAGATCAGGAGGCTTTACTTCATATGGGTTTGCAGAGACATCCAGTCTTTCCGCTGG
  1261 TTTGCTGATTTGCTCTGCAAATTGCATGACAAGTTCTGGCAAGAAAACCGACCAGATTTT
  1321 GTAAATATCCAGTTATACCTCAGTCGAACAGATGGGATACAGAAGATAATTGGAGAGAAA
  1381 TACCAAGTGCTGAACCGCCGGCTTTTCATTGGGCGACCTCGCTGGAAGCTTCTATTTAAT
  1441 GAAATCGCCAAGTGCAACAGACAGAAGACTGTTGGCGTTTTTTGCTGTGGACCCAGTGGA
  1501 ATTTCAAAAGTGCTCCACAAACTGAGCAACAGCAGCAACCCTTATGGGACAAGGTTTGAA
  1561 TACAATAAAGAATCCTTCAGCTGA

Predicted Protein Product
QLGLCVSRASASILNLNCSLVLLPVCRILLAFLRGSQKVPSRKTRRLLDKSKTFHVTCGV
MICIFSVIHVGAHLVNALNFSVNYSEQFLALNVANYRGEDPRKLLFTTVPGLTGVLMVLV
LFLMSTASTYAIRVSNYDIFWYTHNLFFVFYLLLMLHVSGGVLKYQTNVKEHPPGCFNPN
RTIQEGRDFEKSHPENAWEPFPRRLVEMEPLLKSNIVCIEEPKFQAHFPETWLWISGPLC
LYCAERLYRYICSSNKPVTITAVISHACDVLEVRMMKEDFRARPGQYVILHCPGVSSVES
HPFTLTLCPTATKATFGVHVKVVGDWTERFRDLLFLHSSLDAEFLPVFQQRHYPKLYVDG
PFGSPFEESFNYEVSLCVAGGIGVTPFASILNTLLDEWECYKIRRLYFIWVCRDIQSFRW
FADLLCKLHDKFWQENRPDFVNIQLYLSRTDGIQKIIGEKYQVLNRRLFIGRPRWKLLFN
EIAKCNRQKTVGVFCCGPSGISKVLHKLSNSSNPYGTRFEYNKESFS
Protein Alignment to Mouse
sp|Q9JHI8|NOX4_MOUSE NADPH oxidase 4 OS=Mus musculus GN=Nox4 PE=1 SV=1
      MGI:1354184 Nox4 NADPH oxidase 4 (Chr 7)
        Length = 578

 Score = 2212 (783.7 bits), Expect = 6.0e-230, P = 6.0e-230
 Identities = 406/528 (76%), Positives = 456/528 (86%)

Query:     2 LGLCVSRASASILNLNCSLVLLPVCRILLAFLRGSQKVPSRKTRRLLDKSKTFHVTCGVM 61
             LGLC+SRASAS+LNLNCSL+LLP+CR +LA+LRGSQKVPSR+TRRLLDKSKT H+TCGV 
Sbjct:    52 LGLCLSRASASVLNLNCSLILLPMCRTVLAYLRGSQKVPSRRTRRLLDKSKTLHITCGVT 111

Query:    62 ICIFSVIHVGAHLVNALNFSVNYSEQFLALNVANYRGEDPRKLLFTTVPGLTGVLMVLVL 121
             ICIFS +HV AHLVNALNFSVNYSE FL LN A Y+ EDPRKLLFTT+PGLTGV MV+VL
Sbjct:   112 ICIFSGVHVAAHLVNALNFSVNYSEDFLELNAARYQNEDPRKLLFTTIPGLTGVCMVVVL 171

Query:   122 FLMSTASTYAIRVSNYDIFWYTHNLFFVFYLLLMLHVSGGVLKYQTNVKEHPPGCFNPNR 181
             FLM TASTYAIRVSNYDIFWYTHNLFFVFY+LL+LHVSGG+LKYQTNV  HPPGC + N+
Sbjct:   172 FLMVTASTYAIRVSNYDIFWYTHNLFFVFYMLLLLHVSGGLLKYQTNVDTHPPGCISLNQ 231

Query:   182 TIQEGRDFEKSHPENAWEPFPRRLVEMEPLLKSNIV--CIEEPKFQAHFPETWLWISGPL 239
             T  +         E+     PR   ++E   +  +V  C+EEPKFQAHFP+TW+WISGPL
Sbjct:   232 TSSQNMSIPDYVSEHFHGSLPRGFSKLEDRYQKTLVKICLEEPKFQAHFPQTWIWISGPL 291

Query:   240 CLYCAERLYRYICSSNKPVTITAVISHACDVLEVRMMKEDFRARPGQYVILHCPGVSSVE 299
             CLYCAERLYR I  SNKPVTI +VI+H  DV+E+RM+KE+F+ARPGQY+ILHCP VS++E
Sbjct:   292 CLYCAERLYRCI-RSNKPVTIISVINHPSDVMELRMIKENFKARPGQYIILHCPSVSALE 350

Query:   300 SHPFTLTLCPTATKATFGVHVKVVGDWTERFRDLLFLHSSLDAEFLPVFQQRHYPKLYVD 359
             +HPFTLT+CPT TKATFGVH KVVGDWTERFRDLL   SS D+E LP    R+YPKLY+D
Sbjct:   351 NHPFTLTMCPTETKATFGVHFKVVGDWTERFRDLLLPPSSQDSEILPFIHSRNYPKLYID 410

Query:   360 GPFGSPFEESFNYEVSLCVAGGIGVTPFASILNTLLDEWECYKIRRLYFIWVCRDIQSFR 419
             GPFGSPFEES NYEVSLCVAGGIGVTPFASILNTLLD+W+ YK+RRLYFIWVCRDIQSF+
Sbjct:   411 GPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFQ 470

Query:   420 WFADLLCKLHDKFWQENRPDFVNIQLYLSRTDGIQKIIGEKYQVLNRRLFIGRPRWKLLF 479
             WFADLLC LH+KFWQENRPDFVNIQLYLS+TDGIQKIIGEKY  LN RLFIGRPRWKLLF
Sbjct:   471 WFADLLCVLHNKFWQENRPDFVNIQLYLSQTDGIQKIIGEKYHTLNSRLFIGRPRWKLLF 530

Query:   480 NEIAKCNRQKTVGVFCCGPSGISKVLHKLSNSSNPYGTRFEYNKESFS 527
             +EIAKCNR KTVGVFCCGPS ISK LH LSN +N YGT+FEYNKESFS
Sbjct:   531 DEIAKCNRGKTVGVFCCGPSSISKTLHSLSNRNNSYGTKFEYNKESFS 578