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Gene Model: Folh1

NomenclatureGenomic Location
SymbolFolh1Chromosome2
NameGlutamate carboxypeptidase 2Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates2: 48 Mbp

Molecular Function

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate.

Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Molecular Function Terms:

catalytic activity
   hydrolase activity
      peptidase activity
         peptidase activity, acting on L-amino acid peptides
            exopeptidase activity
               carboxypeptidase activity
               dipeptidase activity
            metallopeptidase activity

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGTGGACCACTCTGCAAGCTGCCACCGAACCCACTTTCACAGGGGGCACCAGCTGTGGC
    61 AGCCGGAGACGCTTCTGGGTGCTGGCTGTGGGGCTGGTAGTCGCCGTGTTCCTGCTTGGC
   121 TTCCTTATCGGCTGGCTGAGTAATACAGATCAATCACCAAAGACATGCTCTCATCAGAAG
   181 ATGAAGAGAGTGTTTATGAAAGAAATGAAAGCAGAGAACATCAAGGATTTTTTACGTAAT
   241 TTTACTCAGCAGCCTCACCTGGCTGGCACACAGGAGAATCTACACCTGGCTGAACAAATA
   301 CAAGCCCAGTGGGAGGCATTTGGCCTGGACTCAGTTCACCTGGCTCCTTACGACGTTCTG
   361 CTTTCCTACCCAAATGAGACAAATCCCAATTACATCTCAATTCTTGATGAGCATGGAAAT
   421 GAGATTTTCAATACCTCGTTATTTGAGCCGCCACCCCCAGGATATGAAAATATTGATAAT
   481 GTTGTACCTCCTTACAGTGCTTTCTCAGCCCAGGGAATGCCAGAGGGAGATCTGGTATAT
   541 GTAAACTATGGCAGCATAGAAGACTTCCACAAACTGGAGCAAGAGATGGGAATTAATTGC
   601 TCTGGGAAAATTGTCATTGCAAGATATGGGAAAATCTTCAGAGGAAATAAGGTTAAGAAT
   661 GCTGAAATGGCAGGTGCCAAGGGTGTTATTTTGTACTCTGACCCTGCTAACTCCTGCGCT
   721 CCTGGAGTACATCCATACCCAGATGGCTGGAATCTTCCAGGAGGTGGAGCCCAACGTGGA
   781 AATGTGCTGATCCTGAATGGCGCTGGGGATCCACTTACTCCAGGCTACCCAGCAAAAGAA
   841 TACCTTTACCGCTATGATGAATCTGAAGCAGCAGCTCGTTTATCTATTCCTGTCCACCCC
   901 ATTGGCTATCACAATGCTGAAAGGCTGCTGAGGGAAATGGGTGGACGTCCCCCACCAGAT
   961 GACAGTTGGAAGGGAAATCTCTCCGTGTCTTACAACATTGGTCCTGGCTTTAAAGGAAGT
  1021 GCTTCCAAAAGCAAAGTCAAAATGCATATCCACAGTCTCAAGGAAGTGAGAAGAATCTAC
  1081 AATGTGATTGGTACTCTCCGAGGTGCAATAGAGCCAGACAGGTACGTTATCCTTGGTGGC
  1141 CACCGTGACTCTTGGGTGTTTGGTGGGATCGACCCTCAAAGCGGAGCTGCTGTCGTTCAT
  1201 GAGATTGTCAGAAGTTTTGGGAAGCTGAAACAGGAAGGATGGAGGCCTAGAAGAACAATA
  1261 ATATTTGCCAGCTGGGATGCTGAGGAGTTTGGCCTGATAGGCTCAACGGAATGGGCTGAG
  1321 GAAAATGTCAAAATATTACAGGATCGTGCAGTGGCATATATCAATGCTGATTCCTCCATA
  1381 GAAGGAAACTATACTCTTCGAGTTGACTGTACTCCACTGATGCATAGCCTTGTATATAAT
  1441 CTGACTAGGGAGATACCAAGCCCCGATGAAGAGTTTGAAGGCAAATCTCTTTATGAAAGT
  1501 TGGTATGAAAAAAACCCATCCACAGAACCTAAAGGTGTTCCCAGGATCAACAAGCTGGGC
  1561 TCTGGCAATGACTTTGAAGTCTTTTTCCAAAGGTTGGGCATTGCTTCCGGCAGAGCTCGT
  1621 TACACCAAAAATTTGAAAGTGGACAAATACAGCAGCTACCCAGTTTATCACAGTGTCTAT
  1681 GAGACCTATGAGATTGTGGAACGGTTCTATGATCCCACTTTTAAGAACCACCTGGCTGTA
  1741 GCCCAAGTCCGAGGAGGGCTGGTGTTTGAACTGGCTGACTCCATCATCATTCCCTTTGAT
  1801 TGTCGGGATTATGCTGCAGCACTGAGCAGCTATGCAAGAGTAATTTACAATATAACCCTG
  1861 AAACACCAAACAGCAGTGGAAACCTATGAGGTATCCTTTGATTCCCTTTTTGATGCAGTG
  1921 AATAACTTTTCAGAAGTTGCCAGCGACTTTCACAAGAGACTACAAATCCTGAACATCAAT
  1981 AACCCAATTGAAGTGAGAGCTTTGAATGACCAGCTGATGTTTTTGGAAAGAGCATTTATT
  2041 GATCCCCTTGGATTACCTGGCAGGGCATTCTATAGAAAAAAAATCAGACACATCATCTTT
  2101 GCCCCAAATAACCACAATAAGTATGCTGGAGTATCGTTCCCTGGAATCTATGATGCACTT
  2161 TTTGACATTGACCACAAGCCAGACCAGCGCAAGGCCTGGGAAGAAGTCAAGAAGCAGATC
  2221 TCCATTGCAGCCTTCACGGTGGCAGCTGCAGCTGGGACCCTGAAAGAGCCATTTTGA

Predicted Protein Product
MWTTLQAATEPTFTGGTSCGSRRRFWVLAVGLVVAVFLLGFLIGWLSNTDQSPKTCSHQK
MKRVFMKEMKAENIKDFLRNFTQQPHLAGTQENLHLAEQIQAQWEAFGLDSVHLAPYDVL
LSYPNETNPNYISILDEHGNEIFNTSLFEPPPPGYENIDNVVPPYSAFSAQGMPEGDLVY
VNYGSIEDFHKLEQEMGINCSGKIVIARYGKIFRGNKVKNAEMAGAKGVILYSDPANSCA
PGVHPYPDGWNLPGGGAQRGNVLILNGAGDPLTPGYPAKEYLYRYDESEAAARLSIPVHP
IGYHNAERLLREMGGRPPPDDSWKGNLSVSYNIGPGFKGSASKSKVKMHIHSLKEVRRIY
NVIGTLRGAIEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGKLKQEGWRPRRTI
IFASWDAEEFGLIGSTEWAEENVKILQDRAVAYINADSSIEGNYTLRVDCTPLMHSLVYN
LTREIPSPDEEFEGKSLYESWYEKNPSTEPKGVPRINKLGSGNDFEVFFQRLGIASGRAR
YTKNLKVDKYSSYPVYHSVYETYEIVERFYDPTFKNHLAVAQVRGGLVFELADSIIIPFD
CRDYAAALSSYARVIYNITLKHQTAVETYEVSFDSLFDAVNNFSEVASDFHKRLQILNIN
NPIEVRALNDQLMFLERAFIDPLGLPGRAFYRKKIRHIIFAPNNHNKYAGVSFPGIYDAL
FDIDHKPDQRKAWEEVKKQISIAAFTVAAAAGTLKEPF
Protein Alignment to Mouse
sp|O35409|FOLH1_MOUSE Glutamate carboxypeptidase 2 OS=Mus musculus GN=Folh1
            PE=2 SV=2
      MGI:1858193 Folh1 folate hydrolase (Chr 7)
        Length = 752

 Score = 2717 (961.5 bits), Expect = 1.8e-283, P = 1.8e-283
 Identities = 509/714 (71%), Positives = 590/714 (82%)

Query:    44 GW-LSNTDQSPKTCSHQKMKRVFMKEMKAENIKDFLRNFTQQPHLAGTQENLHLAEQIQA 102
             GW +  ++++    SH  MK+ F+ E+KAENIK FL NFT+ PHLAGTQ N  LA+QI  
Sbjct:    41 GWFIKPSNEATGNVSHSGMKKEFLHELKAENIKKFLYNFTRTPHLAGTQNNFELAKQIHD 100

Query:   103 QWEAFGLDSVHLAPYDVLLSYPNETNPNYISILDEHGNEIFNTSLFEPPPPGYENIDNVV 162
             QW+ FGLD V L+ YDVLLSYPN+T+PNYISI++E GNEIF TSL E PPPGYENI +VV
Sbjct:   101 QWKEFGLDLVELSHYDVLLSYPNKTHPNYISIINEDGNEIFKTSLSEQPPPGYENISDVV 160

Query:   163 PPYSAFSAQGMPEGDLVYVNYGSIEDFHKLEQEMGINCSGKIVIARYGKIFRGNKVKNAE 222
             PPYSAFS QG PEGDLVYVNY   EDF KLE+EM I+CSGKIVIARYGK+FRGN VKNA+
Sbjct:   161 PPYSAFSPQGTPEGDLVYVNYARTEDFFKLEREMKISCSGKIVIARYGKVFRGNMVKNAQ 220

Query:   223 MAGAKGVILYSDPANSCAPGVHPYPDGWNLPGGGAQRGNVLILNGAGDPLTPGYPAKEYL 282
             +AGAKG+ILYSDPA+   P V  YPDGWNLPGGG QRGNVL LNGAGDPLTPGYPA E+ 
Sbjct:   221 LAGAKGMILYSDPADYFVPAVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEHA 280

Query:   283 YRYDESEAAARLSIPVHPIGYHNAERLLREMGGRPPPDDSWKGNLSVSYNIGPGFKGSAS 342
             YR++ + A    SIPVHPIGY +A++LL  MGG  PPD SWKG L V YN+GPGF G+ S
Sbjct:   281 YRHELTNAVGLPSIPVHPIGYDDAQKLLEHMGGPAPPDSSWKGGLKVPYNVGPGFAGNFS 340

Query:   343 KSKVKMHIHSLKEVRRIYNVIGTLRGAIEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEI 402
               KVKMHIHS  +V RIYNVIGTL+GA+EPDRYVILGGHRD+WVFGGIDPQSGAAVVHEI
Sbjct:   341 TQKVKMHIHSYTKVTRIYNVIGTLKGALEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEI 400

Query:   403 VRSFGKLKQEGWRPRRTIIFASWDAEEFGLIGSTEWAEENVKILQDRAVAYINADSSIEG 462
             VRSFG LK++G RPRRTI+FASWDAEEFGL+GSTEWAEE+ ++LQ+R VAYINADSSIEG
Sbjct:   401 VRSFGTLKKKGRRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEG 460

Query:   463 NYTLRVDCTPLMHSLVYNLTREIPSPDEEFEGKSLYESWYEKNPSTEPKGVPRINKLGSG 522
             NYTLRVDCTPLM+SLVYNLT+E+ SPDE FEGKSLY+SW EK+PS E  G+PRI+KLGSG
Sbjct:   461 NYTLRVDCTPLMYSLVYNLTKELQSPDEGFEGKSLYDSWKEKSPSPEFIGMPRISKLGSG 520

Query:   523 NDFEVFFQRLGIASGRARYTKNLKVDKYSSYPVYHSVYETYEIVERFYDPTFKNHLAVAQ 582
             NDFEVFFQRLGIASGRARYTKN K +K SSYP+YHSVYETYE+V +FYDPTFK HL VAQ
Sbjct:   521 NDFEVFFQRLGIASGRARYTKNWKTNKVSSYPLYHSVYETYELVVKFYDPTFKYHLTVAQ 580

Query:   583 VRGGLVFELADSIIIPFDCRDYAAALSSYARVIYNITLKHQTAVETYEVSFDSLFDAVNN 642
             VRG +VFELA+SI++PFDC+ YA AL  YA  IYNI++KH   ++ Y +SFDSLF AVNN
Sbjct:   581 VRGAMVFELANSIVLPFDCQSYAVALKKYADTIYNISMKHPQEMKAYMISFDSLFSAVNN 640

Query:   643 FSEVASDFHKRLQILNINNPIEVRALNDQLMFLERAFIDPLGLPGRAFYRKKIRHIIFAP 702
             F++VAS F++RLQ L+ +NPI +R +NDQLM+LERAFIDPLGLPGR FYR    HII+AP
Sbjct:   641 FTDVASKFNQRLQELDKSNPILLRIMNDQLMYLERAFIDPLGLPGRPFYR----HIIYAP 696

Query:   703 NNHNKYAGVSFPGIYDALFDIDHKPDQRKAWEEVKKQISIXXXXXXXXXGTLKE 756
             ++HNKYAG SFPGIYDALFDI  K +  KAW EVK+QISI          TL+E
Sbjct:   697 SSHNKYAGESFPGIYDALFDISSKVNASKAWNEVKRQISIATFTVQAAAETLRE 750