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Gene Model: Hdac1

NomenclatureGenomic Location
SymbolHdac1Chromosome1
NameHistone deacetylase 1Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates1: 37 Mbp

Molecular Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.

Molecular Function Terms:

binding
   chromatin binding
   nucleic acid binding
      DNA binding
   protein binding
      enzyme binding
         histone deacetylase binding
      transcription factor binding
         activating transcription factor binding
         NF-kappaB binding

catalytic activity
   hydrolase activity
      deacetylase activity
         protein deacetylase activity
            histone deacetylase activity
            NAD-dependent protein deacetylase activity

Human Disease Association

No disease association.

Predicted Transcript
     1 GGAGGCGGCGGCGGGAGAAGGAAGATGGCGCTGACTCAGGGGACCAAGCGGAAAGTCTGC
    61 TACTATTATGACGGGGACATTGGAAACTACTATTATGGCCAAGGCCACCCCATGAAGCCT
   121 CACAGGATCAGGATGACACACAACCTCCTCCTCAACTACGGCCTTTACAGGAAAATGGAG
   181 ATCTATAGGCCCTACAAAGCCAGTGCTGAAGAAATGACCAAATACCACAGTGACGACTAC
   241 ATCAAATTCCTGCGCTCAATTCGCCCAGACAATATGTCTGAGTACAGCAAGCAGATGCAG
   301 CGATTCAACGTCGGAGAGGATTGCCCTGTCTTTGATGGCTTGTTTGAGTTTTGTCAGCTT
   361 TCTACAGGAGGCTCGGTTGCCAGTGCAGTGAAACTGAACAAGCAGCAGACGGACATCGCA
   421 GTCAATTGGGCAGGAGGCTTGCATCACGCCAAGAAATCTGAGGCCTCAGGCTTCTGCTAC
   481 GTCAACGACATTGTTTTGGCCATTTTGGAGTTGCTCAAGTACCACCAGAGAGTGCTGTAT
   541 GTGGACATCGACATCCACCACGGCGACGGTGTGGAGGAGGCGTTCTACACCACAGACCGC
   601 GTGATGACGGCGTCCTTCCATAAATATGGCGAATACTTTCCTGGAACAGGAGACCTGCGG
   661 GACATTGGTGCAGGCAAAGGGAAGTACTACGCCGTCAATTATCCTCTCAGGGATGGAATC
   721 GATGACGAATCTTATGAAGCCATTTTCAAGCCGGTGATGTCCAAAGTCATGGAGACGTTC
   781 CAGCCGAGCGCTGTGGCCTTGCAGTGTGGCTCCGACTCCTTGTCGGGGGACAGATTAGGC
   841 TGCTTCAATCTTACTATTAAAGGTCACGCCAAGTGTGTGGAGTTCATAAAAAGCTTTAAC
   901 TTGCCAATGCTAATGCTTGGAGGAGGCGGCTACACCATCCGCAACGTGGCCCGGTGCTGG
   961 ACGTACGAGACTGCCGTGGCCCTGAACACGGAGATCCCAAATGAGCTTCCTTACAACGAT
  1021 TACTTCGAATACTTTGGCCCGGACTTCAAGCTCCACATCAGCCCTTCCAACATGACGAAC
  1081 CAAAACACCAACGAGTACCTGGAGAAGATTAAGCAGCGTCTCTTTGAGAACCTGCGGATG
  1141 CTTCCTCACGCTCCGGGGGTCCAGATGCAGCCCATTCCAGAAGACGCTGTGCCAGAAGAT
  1201 AGTGCGGATGAAGACGAGGAAGATCCCGACAAGCGGATTTCCATCCGCTCCTCGGATAAG
  1261 AGGATCGCGTGCGATGAGGAATTCTCAGATTCCGAGGACGAAGGCGAAGGCGGGCGCAAG
  1321 AACGTGGCCAACTTCAAGAAGGCCAAGCGCGCAAAGACTGAGGAGGAGGAGAAAGAGGAA
  1381 GAGAAGAAAGCAACAGAAGTCAAGGAAGAAGATAAAGCGAAAGAAGAAACGGTGGAGCCC
  1441 AAAGGCTTGGCTGCTGCTAGGAAGGAAGAAGGAAGAAAAAGG

Predicted Protein Product
GGGGGRRKMALTQGTKRKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKME
IYRPYKASAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQL
STGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLY
VDIDIHHGDGVEEAFYTTDRVMTASFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGI
DDESYEAIFKPVMSKVMETFQPSAVALQCGSDSLSGDRLGCFNLTIKGHAKCVEFIKSFN
LPMLMLGGGGYTIRNVARCWTYETAVALNTEIPNELPYNDYFEYFGPDFKLHISPSNMTN
QNTNEYLEKIKQRLFENLRMLPHAPGVQMQPIPEDAVPEDSADEDEEDPDKRISIRSSDK
RIACDEEFSDSEDEGEGGRKNVANFKKAKRAKTEEEEKEEEKKATEVKEEDKAKEETVEP
KGLAAARKEEGRKR
Protein Alignment to Mouse
sp|O09106|HDAC1_MOUSE Histone deacetylase 1 OS=Mus musculus GN=Hdac1 PE=1 SV=1
      MGI:108086 Hdac1 histone deacetylase 1 (Chr 4)
        Length = 482

 Score = 1979 (701.7 bits), Expect = 2.9e-205, P = 2.9e-205
 Identities = 377/437 (86%), Positives = 383/437 (87%)

Query:     9 MALTQGTKRKVCXXXXXXXXXXXXXXXHPMKPHRIRMTHNLLLNYGLYRKMEIYRPYKAS 68
             MA TQGTKRKVC               HPMKPHRIRMTHNLLLNYGLYRKMEIYRP+KA+
Sbjct:     1 MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN 60

Query:    69 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS 128
             AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
Sbjct:    61 AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS 120

Query:   129 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYVDIDIHHG 188
             AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLY+DIDIHHG
Sbjct:   121 AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG 180

Query:   189 DGVEEAFYTTDRVMTASFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI 248
             DGVEEAFYTTDRVMT SFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
Sbjct:   181 DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI 240

Query:   249 FKPVMSKVMETFQPSAVALQCGSDSLSGDRLGCFNLTIKGHAKCVEFIKSFNLPMLMLGG 308
             FKPVMSKVME FQPSAV LQCGSDSLSGDRLGCFNLTIKGHAKCVEF+KSFNLPMLMLGG
Sbjct:   241 FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG 300

Query:   309 GGYTIRNVARCWTYETAVALNTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE 368
             GGYTIRNVARCWTYETAVAL+TEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
Sbjct:   301 GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE 360

Query:   369 KIKQRLFENLRMLPHAPGVQMQPIXXXXXXXXXXXXXXXXXXKRISIRSSDKRIACXXXX 428
             KIKQRLFENLRMLPHAPGVQMQ I                  KRISI SSDKRIAC    
Sbjct:   361 KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEF 420

Query:   429 XXXXXXXXXXRKNVANF 445
                       RKN +NF
Sbjct:   421 SDSDEEGEGGRKNSSNF 437