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Gene Model: En2

NomenclatureGenomic Location
SymbolEn2Chromosome2
NameHomeobox protein engrailed-2Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates2: 24 Mbp

Molecular Function

Molecular Function Terms:

binding
   nucleic acid binding
      DNA binding
         sequence-specific DNA binding

nucleic acid binding transcription factor activity
   sequence-specific DNA binding transcription factor activity

Human Disease Association

Note=Genetic variations in EN2 may be associated with susceptibility to autism.

Predicted Transcript
     1 GAGCAGGAGCAGCAGCAGCAGCAAGCCCAAGCCCGTCCCCAGCAGCACCCGGAGGAGTCC
    61 AGCAGCGGGAGCGAAGCGGAGCCCAACCGGCGCCGGGCGGCGATGCTCCTGCCCCGGGTG
   121 CTCCAGCCGCCCCACCGGATCACCAACTTTTTCATCGACAACATCCTGCGGCCGGAGTTC
   181 GGGAGGAGGAAGGAGGACGGCACCGGGCTTGGCTCAGACTCTCCGCAGCAAGCCCAGCAG
   241 CAGCAGACCCCGCCGCACCTCCACCAGCCGCCGCTCCTGCCCGCCAGGAGCCCCTCGACC
   301 TCCCCGGCGGAAGGAGGAGGAGGCGGCGGTGGTGGCTCCAAAGCCCTGCTGGTCCCGGCC
   361 AAGAAAGGAGACGACTCGGGGGAGGTGGTGGACGGAGCCCTGAAGCCCGGCGCCGGAGGA
   421 GGAGGAGGAGGAGGAGGGGGCGGCAGCAGCAGCGGGGGAGGCGGCGGAGGTGACCTCTCG
   481 CTCAGCTCGGACTCGGACAGCTCCCAGGCCAGCTCTTTCCCCAACGGGCAGCCCATGCTG
   541 TGGCCCGCCTGGGTCTACTGCACCCGCTACTCGGACAGGCCTTCGTCAGGCCCCAGGTCG
   601 CGAAAACCAAAGAAGAAGAACCCCAACAAGGAGGACAAGCGCCCAAGGACCGCCTTCACC
   661 GCCGAGCAGCTGCAAAGGCTCAAAGCGGAGTTTCAGACGAACAGATACTTGACGGAGCAG
   721 AGGCGGCAGAGCCTCGCCCAGGAACTCAGCCTCAACGAGTCGCAGATCAAGATCTGGTTC
   781 CAGAACAAGCGGGCCAAGATCAAGAAGGCCACCAGCAACAAGAACTCCTTGGCGGCCCAC
   841 CTCATGGCACAAGGGCTGTACAACCACTCCACGGCCTCGAAAGACGGCAAGTCCGACAGC
   901 GAGTAG

Predicted Protein Product
EQEQQQQQAQARPQQHPEESSSGSEAEPNRRRAAMLLPRVLQPPHRITNFFIDNILRPEF
GRRKEDGTGLGSDSPQQAQQQQTPPHLHQPPLLPARSPSTSPAEGGGGGGGGSKALLVPA
KKGDDSGEVVDGALKPGAGGGGGGGGGGSSSGGGGGGDLSLSSDSDSSQASSFPNGQPML
WPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQ
RRQSLAQELSLNESQIKIWFQNKRAKIKKATSNKNSLAAHLMAQGLYNHSTASKDGKSDS
E
Protein Alignment to Mouse
sp|P09066|HME2_MOUSE Homeobox protein engrailed-2 OS=Mus musculus GN=En2 PE=2
            SV=2
      MGI:95390 En2 engrailed 2 (Chr 5)
        Length = 324

 Score = 465 (168.7 bits), Expect = 1.4e-61, Sum P(3) = 1.4e-61
 Identities = 93/125 (74%), Positives = 96/125 (76%)

Query:   177 QPMLWPAWVYCTRYXXXXXXXXXXXXXXXXXXXXXXXXXXTAFTAEQLQRLKAEFQTNRY 236
             QPMLWPAWVYCTRY                          TAFTAEQLQRLKAEFQTNRY
Sbjct:   200 QPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRY 259

Query:   237 LTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATSNKNSLAAHLMAQGLYNHSTASKDG 296
             LTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKAT NKN+LA HLMAQGLYNHST +K+G
Sbjct:   260 LTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEG 319

Query:   297 KSDSE 301
             KSDSE
Sbjct:   320 KSDSE 324

 Score = 148 (57.2 bits), Expect = 1.4e-61, Sum P(3) = 1.4e-61
 Identities = 32/44 (72%), Positives = 35/44 (79%)

Query:    31 RRAAMLLPRVLQ-P-----PHRITNFFIDNILRPEFGRRKEDGT 68
             RR A++LP VLQ P     PHRITNFFIDNILRPEFGRRK+ GT
Sbjct:    40 RRRALMLPEVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDAGT 83

 Score = 40 (19.1 bits), Expect = 1.4e-61, Sum P(3) = 1.4e-61
 Identities = 9/16 (56%), Positives = 10/16 (62%)

Query:   120 AKKGDDSGEVVDGALK 135
             AKK  D G  +DG LK
Sbjct:   158 AKKPGDPGGSLDGVLK 173