Home Search Reports Help

Gene Model: Wls

NomenclatureGenomic Location
SymbolWlsChromosome2
NameProtein wntless homologLinkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates2: 82 Mbp

Molecular Function

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development.

Molecular Function Terms:

binding
   protein binding
      Wnt-protein binding

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGGCTGGGGCAATTATCGAGAACATGAGCACCAAGAAGCTCTGCATTGTCGGGGCGACC
    61 CTGCTGGTGTTCCAAGTCGTCGCCTTTCTGGTGGGAGGTCTGATCGCTCCAAGTCCGACT
   121 ACTGCTGTGCCCTATGTGGCAATAAAGTGCATAGATACGCGGAAAAACCACCACAAGAAC
   181 AAATGGTTTATGCCCTGGGGACCAAACCAGTGTGAAAAAATCAGGGATCTGGATGAAGCG
   241 ATGGGCAGACACATAGAAGCCAGCAACATTGTGTTTTCAGTTCACATGCCACTTCCCAAC
   301 AAAGAGATGAGTCCTTGGTTCCAGTTCATGTTGTACATTTTGCATATGGACATTGCTTTC
   361 AAGACTGACAACCAGATTAAAGAAAATGCTGAAGTTACACTTGAGGTGTCTTTGGCATAT
   421 CGTGATGTCATGGGTGGCCCTTGGGAAGAAATGTCTCATGCAACAGAAACCCGGAAGCTG
   481 AAATGTAGTTTTGGAGCTCCAAAAACGCACGAGCATGAAGGGAAGTTTTATGACTGCGAT
   541 GTACTGCCATTCATGGAGATTGGAACTGTTGCTCATAAGTATTATCTTGTCAACATTCGT
   601 CTTCCAGTGAATGAGAAGAAGGGCATCAATGTGGGAATTGGTGAAATAAAAGATATCCGT
   661 CTAGTGGGTATCCATCAAAATGGTGGGTTTACAAAGGTATGGTTTGCAATGAAGACCTTC
   721 CTTACACCTAGTATCCTCATTATCATGATTTGGTACTGGAGACGGATCACGCAGATGACA
   781 CGGCCACCTGTACTCCTGGAAAAAGTTATTTTTGCTCTTGGGATCTCCATGACCTTCATA
   841 AACATCCCAGTAGAGTGGTTTTCTATTGGATTTGACTGGACGTGGATGTTACTTTTTGGA
   901 GACATTCGCCAAGGAATCTTTTATGCTATGCTTCTCTCCTTTTGGATCATCTTCTGTGGA
   961 GAGCATATGATGGACCAGAGTGAACGAAATCATTTTTCATCTTACTGGAAACAAGTTGGA
  1021 CCAATAGCTGTGGGATCTTTCTGTCTCTTTGTCTTTGATATGTGTGAGAGAGGGGTGCAA
  1081 TTAAAAAACCCTTTCTATAGTATTTGGGCTACAGATGTTGGCACAGAACTGGCTATGGCA
  1141 TTTATTATCGTTGCTGGAATCTGCCTCTGTCTCTATTTCTTGCTGCTGTGTTTTATGGTG
  1201 TTTCAAGTTTTCAGAAACATCAGTGGCAAGCAATCCAGCCTCCCAGCGATGTCCAAAGCT
  1261 CGAAGGCTTCATTATGAGGGGCTGATTTTTAGGTTCAAGTTTTTGATGCTGATTACCTTA
  1321 GCCTGTGCAGCCATGACGGTAATATTCTTCATTGTCAGTCAGGTGACCGAAGGGCACTGG
  1381 GAAATGGGGCGACTTNGGATGTGGAATCTTTATGTCTTTGCCTTGATGTTCCTGTATGCT
  1441 CCTTCACACAAAAACTACGGTGAAGATCAATCAAATGGTGATCTTGGAGTAAACAGCGGA
  1501 GAAGAACTTCAGCTTACTACCACTATCACCCACGTGGATGGACCAACAGAGGTTTACAAA
  1561 CTGGCTCGTAAGGAAGCCCAGGAGTAA

Predicted Protein Product
MAGAIIENMSTKKLCIVGATLLVFQVVAFLVGGLIAPSPTTAVPYVAIKCIDTRKNHHKN
KWFMPWGPNQCEKIRDLDEAMGRHIEASNIVFSVHMPLPNKEMSPWFQFMLYILHMDIAF
KTDNQIKENAEVTLEVSLAYRDVMGGPWEEMSHATETRKLKCSFGAPKTHEHEGKFYDCD
VLPFMEIGTVAHKYYLVNIRLPVNEKKGINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTF
LTPSILIIMIWYWRRITQMTRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFG
DIRQGIFYAMLLSFWIIFCGEHMMDQSERNHFSSYWKQVGPIAVGSFCLFVFDMCERGVQ
LKNPFYSIWATDVGTELAMAFIIVAGICLCLYFLLLCFMVFQVFRNISGKQSSLPAMSKA
RRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWEMGRLXMWNLYVFALMFLYA
PSHKNYGEDQSNGDLGVNSGEELQLTTTITHVDGPTEVYKLARKEAQE
Protein Alignment to Mouse
sp|Q6DID7|WLS_MOUSE Protein wntless homolog OS=Mus musculus GN=Wls PE=1 SV=1
      MGI:1915401 Wls wntless homolog (Drosophila) (Chr 3)
        Length = 541

 Score = 2370 (839.3 bits), Expect = 1.1e-246, P = 1.1e-246
 Identities = 442/541 (81%), Positives = 480/541 (88%)

Query:     1 MAGAIIENMSTKKLCIVGATLLVFQVVAFLVGGLIAPSPTTAVPYVAIKCIDTRKNHHKN 60
             MAGAIIENMSTKKLCIVG  LLVFQ+VAFLVGGLIAP+PTTAVPY AIKC+D RKNHHK 
Sbjct:     1 MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVPYTAIKCVDVRKNHHKT 60

Query:    61 KWFMPWGPNQCEKIRDLDEAMGRHIEASNIVFSVHMPLPNKEMSPWFQFMLYILHMDIAF 120
             +W  PWGPN+C+KIRD++EA+ R IEA++IVFSVH+PLP+ EMSPWFQFML+IL +DIAF
Sbjct:    61 RWLAPWGPNKCDKIRDIEEAIPREIEANDIVFSVHIPLPSMEMSPWFQFMLFILQLDIAF 120

Query:   121 KTDNQIKENAEVTLEVSLAYRDVMGGPWEEMSHATETRKLKCSFGAPKTHEHEGKFYDCD 180
             K +NQI+ENAE++++VSL YRD M   W EM+H    RKLKC+F +PKT EHEG++Y+CD
Sbjct:   121 KLNNQIRENAEISMDVSLGYRDDMFSEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYNCD 180

Query:   181 VLPFMEIGTVAHKYYLVNIRLPVNEKKGINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTF 240
             VLPFMEIG+VAHKYYL+NIRLPVNEKK INVGIGEIKDIRLVGIHQNGGFTKVWFAMKTF
Sbjct:   181 VLPFMEIGSVAHKYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTF 240

Query:   241 LTPSILIIMIWYWRRITQMTRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFG 300
             LTPSI IIM+WYWRRIT M+RPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFG
Sbjct:   241 LTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFG 300

Query:   301 DIRQGIFYAMLLSFWIIFCGEHMMDQSERNHFSSYWKQVGPIAVGSFCLFVFDMCERGVQ 360
             DIRQGIFYAMLLSFWIIFCGEHMMDQ ERNH + YWKQVGPIAVGSFCLF+FDMCERGVQ
Sbjct:   301 DIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQ 360

Query:   361 LKNPFYSIWATDVGTELAMAFIIVAGIXXXXXXXXXXXMVFQVFRNISGKQSSLPAMSKA 420
             L NPFYSIW TDVGTELAMAFIIVAGI           MVFQVFRNISGKQSSLPAMSK 
Sbjct:   361 LTNPFYSIWTTDVGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKV 420

Query:   421 RRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWEMGRLX-------------M 467
             RRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQV+EGHW+ G +              M
Sbjct:   421 RRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVSEGHWKWGGVTVQVSSAFFTGIYGM 480

Query:   468 WNLYVFALMFLYAPSHKNYGEDQSNGDLGVNSGEELQLTTTITHVDGPTEVYKLARKEAQ 527
             WNLYVFALMFLYAPSHKNYGEDQSNGDLGV+SGEELQLTTTITHVDGPTE+YKL RKEAQ
Sbjct:   481 WNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQ 540

Query:   528 E 528
             E
Sbjct:   541 E 541