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Gene Model: Mapk6

NomenclatureGenomic Location
SymbolMapk6Chromosome1
NameMitogen-activated
protein kinase 6		Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates1: 6 Mbp

Molecular Function

Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.

Molecular Function Terms:

binding
   protein binding
   nucleotide binding
      purine nucleotide binding
         adenyl nucleotide binding
            adenyl ribonucleotide binding
               ATP binding
   

catalytic activity
   transferase activity
      transferase activity, transferring phosphorus-containing groups
         kinase activity
            protein kinase activity
               protein serine/threonine kinase activity

molecular transducer activity
   signal transducer activity
      receptor signaling protein activity
         receptor signaling protein serine/threonine kinase activity
            MAP kinase activity

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGGCAGAGAAGTTTGAAAGCCTCATGAACATCCATGGTTTTGATGTAGGTTCTCGGTAT
    61 ATGGACTTAAAACCTCTGGGCTGTGGTGGCAACGGCTTAGTTTTTTCTGCTGTCGATAAT
   121 GACTGCGACAAAAGAGTAGCAGTCAAGAAAATTGTCCTTACAGATCCTCAGAGCGTTAAA
   181 CATGCTCTGCGTGAGATCAAAATTATTAGAAGACTTGACCATGATAACATTGTCAAAGTG
   241 TTTGAAATCCTCGGTCCCAGTGGGAGTCAATTGACAGATGATGTAGGCTCTCTTACAGAA
   301 CTGAACTGTGTTTACATTGTCCAAGAGTATATGGAGACAGATCTGGCTAAACTGGTGGAG
   361 CAGGGGCCCTTACCTGAAGAACATGCTAGGCTCTTCATGTACCAGCTGCTACGTGGGCTC
   421 AAATATATACACTCTGCAAACGTCCTGCACAGAGATCTCAAACCAGCTAACTTGTTCATT
   481 AATACTGAAGACTTGGTGCTGAAAATCGGTGACTTTGGCCTTGCACGGATCATGGATCCT
   541 CATTATTCCCATAAGGGCCATCTTTCCGAAGGACTGGTAACTAAATGGTACAGATCACCT
   601 CGCCTCTTGCTTTCACCCAACAACTATACTAAAGCCATTGATATGTGGGCTGCAGGTTGC
   661 ATCTTTGCTGAAATGCTGACAGGGAAAACCCTCTTTGCAGGTGCACATGAACTTGAACAG
   721 ATGCAGCTTATTTTAGAATCTATTCCTGTTGTGCATGAGGAAGATCGTCAGGAACTTCTT
   781 AGTGTAATCCCAGTTTACATTAAAAGCGATATGACTGAGCCACACAAACCTTTAACTCAG
   841 CTCCTCCCAGGCATTAGCCCTGAAGCACTGGACTTCCTGGAACAAATACTGACCTTTAGT
   901 CCCATGGATCGAATGACAGCAGAAGAAGCTTTGTCCCATCCTTACATGAGTATTTATTCC
   961 TTTCCAACTGATGAGCCTATTTCAAGCCATCCCTTCCACATTGAAGACGAGGTCGATGAT
  1021 ATTCTGCTCATGGATGAAAGTCACAGCCACATCTATAATTGGGAAAGATATCATGACAGT
  1081 CAGTTTTCAGACCAGGAGTGGTCTGCTCATAACACCTTCGAAGCTGACGAGGTTCAGCGT
  1141 GACCCAAGGGCTCTTTCTGACGGGACGGACGAGGAGGAAGTACAAGTAGATCCTCGCAAA
  1201 TATCTGGACGGTGACCGTGAAAAATACCTAGAGGATCCCGCTTTCGATACTCACTTCTCC
  1261 ACTGAACCTTGCTGGCCATATCCAGATCACCATGAAAACAAATATTGTGATCTAGAATGT
  1321 AGCCACACGTGTAATTACAAAATGAGGTCATCTTCGTACCTAGATAATTTAGTCTGGAGA
  1381 GAAAGTGAGGTGAACCATTACTATGAGCCCAAGCTTATAATTGATCTTTCTAACTGGAAA
  1441 GAGCAGAGTAAAGAGAAGTCAGACAAGAAAGGCAAGTCCAAATGTGAAAGGAATGGGTTG
  1501 GTGAAAGCTCGGTTAGCTCTTGAGGAAGCCTCGCAGCAACTTACAGAAAAGGAGAAGAAT
  1561 CAGGGGTTTGACTTTGATTCTTTTATAGCAGGGACTATTCAGCTTAGTTTACAGCATGAG
  1621 TCAACTGATATTGATAAATTAAATGATCTGAATAGCTCAGTGTCCCTCTTGGAGTCAAAA
  1681 GGCATATCGAAATCAGTAAGCAGAGAGAAACAGGAGAAAGGAATGGCCAACTTGGCCCAG
  1741 TTGGAAGCACTCTACCAAAATTCGTGGGATGGCCAGCTTGTAAGTGGAGGAGAGGAGTGC
  1801 TTTCTCATAGACCAGTTTTGTTGTGAAGTTAGGAAAGATGAGCAGATAGAGAAGGAGAAT
  1861 CCATACACCAGTTACCTGGATAGATTTTTTAGCAAGAAGGAAGATACCGAAATGCTAGAA
  1921 ACTGAGCCAGTTGAAGATGGGAAGCCTGTAGAGAAAGAAAGAGAGGGGGGCTTTTTAAGT
  1981 CATAGCGGGGAATTCCTCTTTAACAAGCACCTCGAAGCGATAGGTATCCCTCAGTTCCAC
  2041 AGCCCCGTTGGCTCACCGCTTAAATCAATACAGGCCACCCTAGCACCTTCTGCTATGAAA
  2101 TCATCTCCTCAGATTCCTCATAAAGCATACAGCAGCATTCTGAAACACCTAAACTAA

Predicted Protein Product
MAEKFESLMNIHGFDVGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAVKKIVLTDPQSVK
HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNCVYIVQEYMETDLAKLVE
QGPLPEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP
HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ
MQLILESIPVVHEEDRQELLSVIPVYIKSDMTEPHKPLTQLLPGISPEALDFLEQILTFS
PMDRMTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDESHSHIYNWERYHDS
QFSDQEWSAHNTFEADEVQRDPRALSDGTDEEEVQVDPRKYLDGDREKYLEDPAFDTHFS
TEPCWPYPDHHENKYCDLECSHTCNYKMRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWK
EQSKEKSDKKGKSKCERNGLVKARLALEEASQQLTEKEKNQGFDFDSFIAGTIQLSLQHE
STDIDKLNDLNSSVSLLESKGISKSVSREKQEKGMANLAQLEALYQNSWDGQLVSGGEEC
FLIDQFCCEVRKDEQIEKENPYTSYLDRFFSKKEDTEMLETEPVEDGKPVEKEREGGFLS
HSGEFLFNKHLEAIGIPQFHSPVGSPLKSIQATLAPSAMKSSPQIPHKAYSSILKHLN
Protein Alignment to Mouse
sp|Q61532|MK06_MOUSE Mitogen-activated protein kinase 6 OS=Mus musculus
            GN=Mapk6 PE=1 SV=3
      MGI:1354946 Mapk6 mitogen-activated protein kinase 6 (Chr 9)
        Length = 720

 Score = 3311 (1170.6 bits), Expect = 0., P = 0.
 Identities = 629/720 (87%), Positives = 657/720 (91%)

Query:     1 MAEKFESLMNIHGFDVGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAVKKIVLTDPQSVK 60
             MAEKFESLMNIHGFD+GSRYMDLKPLGCGGNGLVFSAVDNDCDKRVA+KKIVLTDPQSVK
Sbjct:     1 MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK 60

Query:    61 HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNCVYIVQEYMETDLAKLVE 120
             HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELN VYIVQEYMETDLA ++E
Sbjct:    61 HALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLE 120

Query:   121 QGPLPEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP 180
             QGPL EEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP
Sbjct:   121 QGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDP 180

Query:   181 HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ 240
             HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ
Sbjct:   181 HYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQ 240

Query:   241 MQLILESIPVVHEEDRQELLSVIPVYIKSDMTEPHKPLTQLLPGISPEALDFLEQILTFS 300
             MQLIL+SIPVVHEEDRQELLSVIPVYI++DMTEPH+PLTQLLPGIS EALDFLEQILTFS
Sbjct:   241 MQLILDSIPVVHEEDRQELLSVIPVYIRNDMTEPHRPLTQLLPGISREALDFLEQILTFS 300

Query:   301 PMDRMTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDESHSHIYNWERYHDS 360
             PMDR+TAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDE+HSHIYNWERYHD 
Sbjct:   301 PMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDC 360

Query:   361 QFSDQEWSAHNTFEADEVQRDPRALSDGTDEEEVQVDPRKYLDGDREKYLEDPAFDTHFS 420
             QFS+ +W  HN F+ DEVQ DPRALSD TDEEEVQVDPRKYLDGDREKYLEDPAFDT +S
Sbjct:   361 QFSEHDWPIHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTSYS 420

Query:   421 TEPCWPYPDHHENKYCDLECSHTCNYKMRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWX 480
              EPCW YPDHHENKYCDLECSHTCNYK RSS YLDNLVWRESEVNHYYEPKLIIDLSNW 
Sbjct:   421 AEPCWQYPDHHENKYCDLECSHTCNYKTRSSPYLDNLVWRESEVNHYYEPKLIIDLSNWK 480

Query:   481 XXXXXXXXXXXXXXXXRNGLVKARLALEEASQQLTEKEKNQGFDFDSFIAGTIQLSLQHE 540
                             RNGLVKA++ALEEASQQL E+E+ QGFDFDSFIAGTIQLS QH+
Sbjct:   481 EQSKEKSDKRGKSKCERNGLVKAQIALEEASQQLAERERGQGFDFDSFIAGTIQLSAQHQ 540

Query:   541 STDI-DKLNDLNSSVSLLESKG-ISKSVSREKQEKGMANLAQLEALYQNSWDGQLVSGGE 598
             S D+ DKLNDLNSSVS LE K  ISKSVSREKQEKG ANLAQL ALYQ+SWD Q VSGGE
Sbjct:   541 SADVVDKLNDLNSSVSQLELKSLISKSVSREKQEKGRANLAQLGALYQSSWDSQFVSGGE 600

Query:   599 ECFLIDQFCCEVRKDEQIEKENPYTSYLDRFFSKKEDTEMLETEPVEDGKPVEKEREGGF 658
             ECFLI QFCCEVRKDE  EKEN YTSYLD+FFS+KED+EMLETEPVE+GK  E+ RE G 
Sbjct:   601 ECFLISQFCCEVRKDEHAEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERGREAGL 660

Query:   659 LSHSGEFLFNKHLEAIGIPQFHSPVGSPLKSIQATLAPSAMKSSPQIPHKAYSSILKHLN 718
             LS  GEFL +K LE+IG PQFHSPVGSPLKSIQATL PSAMKSSPQIPHK YSSILKHLN
Sbjct:   661 LSGGGEFLLSKQLESIGTPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHKTYSSILKHLN 720