| Nomenclature | Genomic Location |
| Symbol | Dmd | Chromosome | 1 |
| Name | Dystrophin | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | 1: 82 Mbp |
| Molecular Function |
|
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component
of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ)
and at a variety of synapses in the peripheral and central nervous systems and has a structural function
in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.
Molecular Function Terms:
binding
ion binding
cation binding
metal ion binding
protein binding
cytoskeletal protein binding
actin binding
enzyme binding
nitric-oxide synthase binding
glycoprotein binding
dystroglycan binding
protein complex binding
integrin binding
protein domain specific binding
PDZ domain binding
structural molecule activity
structural constituent of muscle
|
| Human Disease Association |
|
Defects in DMD are the cause of Duchenne muscular dystrophy (DMD) [MIM:310200]. DMD is the most
common form of muscular dystrophy; a sex-linked recessive disorder. It typically presents in boys
aged 3 to 7 year as proximal muscle weakness causing waddling gait, toe-walking, lordosis, frequent
falls, and difficulty in standing up and climbing up stairs. The pelvic girdle is affected first,
then the shoulder girdle. Progression is steady and most patients are confined to a wheelchair by
age of 10 or 12. Flexion contractures and scoliosis ultimately occur. About 50% of patients have
a lower IQ than their genetic expectations would suggest. There is no treatment.
Defects in DMD are the cause of Becker muscular dystrophy (BMD) [MIM:300376]. BMD resembles DMD
in hereditary and clinical features but is later in onset and more benign.
Defects in DMD are a cause of cardiomyopathy dilated X-linked type 3B (CMD3B) [MIM:302045]; also
known as X-linked dilated cardiomyopathy (XLCM). Dilated cardiomyopathy is a disorder characterized
by ventricular dilation and impaired systolic function, resulting in congestive heart failure and
arrhythmia. Patients are at risk of premature death.
|
1 TCTCCTGACCAAACTGTTACTGTGGATACGCAAACTCTGGTAACCAAGGAAACCACCATC
61 TCCAAACAAGAAATGCCATCATCTTTGCTTTTGGAGGTGCCAGCCCTGGCTGAATTCAAT
121 AAAGCATGGGCAGACCTTACCGACTGGCTTTCTCTATTGGATCGAGTGATAAAATCCCAA
181 ATAGTCACTGTTGGTGACCTTGATGAAATCAATGATATGATCATCAAACAAAAGGCAACA
241 ATACAGGACTTGGAACAAAGGCGCCCACAATTGGAGGAGCTAATAACAGCAGCACAGAAT
301 CTGAAAAATAAAACCAGCAATCAAGAGGCTCGAACAGTCATTACTGATCGGATTGAAAAG
361 ATACAAAATCAGTGGGATGAAGTGCAGGGACATCTTCACAACCGAAGACAACAGCTGCAT
421 GAAATGCTAAAAGACTCAACACAATGGTTGGAGGCCAGGCAAGAAGCAGAGCAGGTTTTG
481 GAATGTGCTAAAGTGAAACTTGCATCATGGAAGGAGATTTCTTATACTGTGGAAGGACTG
541 AAGAAGCAGAATGCTGAACTTAAGCAATTTGCAAAAGAACTACGGCAGTGGCATATAAAT
601 GTGGATGTGGCAAATGATTTGGCACTTAAGCTTCTCCGGGATTATTCAACTGATGATACC
661 AGAAAAGTAGAACTGATGACCAATAACATTAATGATGCTTGGGCTACGATTAATAAGAGA
721 GTTGGTGAGCGAGAAGCGGCATTAGAAGCAGCCCTGAGGCTCCTGCAACAATTCTACTTG
781 GATCTGGAAAAGTTCCTTGCCTGGCTTACAGAAGCAGAGACAACTGCGAATGTCCTGCAG
841 GATGCTACACACAAAGAGAAAATATTAGAGGATGCCCAGGGTGTTCGGGAGCTTATGAAG
901 CAGTGGCAGGAACTTCAGAAAGAAATTGAGACCCATACGGATATCTTCCACAGCCTGGAT
961 GAAAATGGTCAGAAGATCTTGAGATCTCTAGAAGGTTCTGATGATGCAGCCCTGTTGCAG
1021 AGACGCCTGGATAACATGAACTTCAGATGGAGTGAACTTAGGAAGAAGTCGTTAAATATT
1081 AGGTCTCATCTAGAAGCCAGTTCTGACCAGTGGAGACGACTTCATCTGTCTCTTCAGGAA
1141 CTGTTGGCATGGCTGCAATTGAAAGAAGATGAGTTAAAGCAGCAGGAACCCATTGGTGGA
1201 GATCTTCCCACAGTGCAAAAGCAGAATGACATACACAGGGCCTTTAAGAGGGAATTGAAA
1261 GCTAAGGAACCTGTTATCTCAAGTGCACTTGAAACAGTGCGAATATTCCTAGCAGAGCAG
1321 CCTCTGGAAGGACTAGAAAAACTCTATCATGAGTCTAGAGAGCTGCCTCCTGGGGAAAGA
1381 GCCCAGAATGTGACTCGACTTCTACGAAGGCAAGCAGATGAGGTCAAAACAGAATGGGAT
1441 AAACTAAATCTGCAGTCTGCTGACTGGCAAAAAAAGATAGATGAAGCACTTGAAAGACTC
1501 CAAGAGCTTCAAGAAGCGATGGATGAGTTGGACTTGAAGCTACGTCAGGCTGAAGCTATC
1561 AAGGGGTCTTGGCAGCCGGTGGGGGATTTGCTGATTGACTCTCTGCAAGATCACTTGGAA
1621 AAAATCAAGGTTTACCGAGCAGAAATTGCCCCACTCAAAGAGAATGTAGACAACGTTAAT
1681 GACCTAGCTCATCAATTTACCTCAACTGAGATACAGCTTTCCCCATATTCTCTCAGCCGC
1741 CTTGAAGACCTGAATGAGAGATGGAAACTCCTACAGGTGACCATCGAAGAGCGAATCAGA
1801 CATTTGCATGAGGCTCACCGAGATTTTGGCCCTACTTCTCAACACTTCCTTTCCACTTCT
1861 GTCCAGGGTCCCTGGGAGAGGGCAATATCGCCAAACAAAGTGCCCTACTACATCAATCAT
1921 GAGACTCAAACCACGTGCTGGGATCATCCTAAAATGACAGAGCTGTACCAGTCCTTAGCT
1981 GACTTGAACAATGTTAGATTCTCAGCATACAGAACTGCCATGAAGCTTCGAAGATTGCAG
2041 AAAGCTCTCTGTTTGGATCTTTTGAGTCTGTCTTCTGCATGCGATGCCTTGGACCAGCAC
2101 AACCTCAAACAGAATGACCAGCCAATGGATATACTTCAGATCATCAACTGTTTGACCACA
2161 ATTTATGATCGACTGGAACAAGAGCACAATAGCCTAGTCAACGTCCCTCTCTGCGTAGAT
2221 ATGTGCCTCAACTGGCTTTTGAATGTTTATGACACGGGTCGAACAGGAAAGATCCGGGTC
2281 CTGTCTTTTAAGACTGGCATAATTTCCCTCTGTAAAGCACACCTGGAAGATAAATACAGA
2341 TATCTGTTCAAGCAGGTAGCAAGTCCCACTGGATTCTGTGACCAGCGTCGCCTGGGCCTC
2401 CTCCTTCACGACTCCATCCAGATTCCAAGGCAGCTGGGAGAAGTCGCCTCTTTTGGTGGC
2461 AGCAACATTGAACCAAGTGTTAGGAGCTGCTTTCAGTTTGCCAATAACAAGCCTGAAATT
2521 GAGGCAGCCCTTTTTCTGGATTGGATGAGACTTGAACCACAGTCTATGGTATGGCTGCCA
2581 GTTTTACATAGGGTGGCTGCTGCTGAAACCGCCAAACACCAAGCCAAGTGTAACATCTGT
2641 AAAGAGTGTCCAATTATTGGGTTCAGATATAGAAGCTTAAAGCACTTTAACTATGACATC
2701 TGCCAAAGCTGCTTCTTTTCTGGCCGAGTTGCAAAAGGTCATAAGATGCACTATCCAATG
2761 GTTGAATACTGTACACCAACTACTTCAGGAGAAGACGTTCGTGACTTTGCCAAGGTATTA
2821 AAAAACAAATTCAGAACAAAAAGATACTTTGCAAAACACCCTAGAATGGGTTACCTGCCT
2881 GTCCAAACAGTGTTGGAGGGAGACAACATGGAAACGCCTGCTTCGTCCCCTCAGCTTTCA
2941 CATGATGACACCCATTCACGCATTGAACATTATGCTAGCAGGCTAGCAGAAATGGAGAAC
3001 ACCAATGGAACATACCTGAATGATAGTATTTCTCCTAATGAGAGCATAGATGACGAGCAT
3061 TTGTTAATCCAGCACTACTGCCAAAGTTTGAACCAGGAATCCCCCCTCAGTCAGCCTCGA
3121 AGCCCTGCACAGATTTTAATTTCATTGGAGAGTGAAGAAAGAGGTGAATTGGAAAGAATT
3181 CTTGCAGACTTAGAGGAAGAAAACAGAAACCTGCAAGCAGAGTATGACCGCCTGAAGAAA
3241 CAACATGAAAACAAAGGACTGTCTCCACTGCCATCCCCACCTGAGATGATGCCCATTTCT
3301 CCCCAGAGTCCACGAGACGCTGAACTCATTGCAGAAGCCAAATTGCTTCGTCAGCACAAA
3361 GGCCGTCTAGAAGCCAGGATGCAAATCCTGGAGGATCACAACAAACAGCTGGAATCACAG
3421 TTGCACAGGTTGAGACAGCTGCTGGAACAGCCTCAAGTGGATGCCAAGGTGAATGGTACA
3481 ACTCAGTCTTCTCCTCCTACCTCATTACAGAGGTCAGATAGTAATCAGCCAATGCTTCTT
3541 CGTGTAGTTGGCAGCCAGACTTCAGAATCAATGGGTGAGGATGATCTGCTCAGTCCTCCC
3601 CAGGACACAAGCACAGGGTTAGAAGAAGTCATGGAACAGCTCAACAATTCATTTCCAAGT
3661 ACAAGAGGT
| Predicted Protein Product |
SPDQTVTVDTQTLVTKETTISKQEMPSSLLLEVPALAEFNKAWADLTDWLSLLDRVIKSQ
IVTVGDLDEINDMIIKQKATIQDLEQRRPQLEELITAAQNLKNKTSNQEARTVITDRIEK
IQNQWDEVQGHLHNRRQQLHEMLKDSTQWLEARQEAEQVLECAKVKLASWKEISYTVEGL
KKQNAELKQFAKELRQWHINVDVANDLALKLLRDYSTDDTRKVELMTNNINDAWATINKR
VGEREAALEAALRLLQQFYLDLEKFLAWLTEAETTANVLQDATHKEKILEDAQGVRELMK
QWQELQKEIETHTDIFHSLDENGQKILRSLEGSDDAALLQRRLDNMNFRWSELRKKSLNI
RSHLEASSDQWRRLHLSLQELLAWLQLKEDELKQQEPIGGDLPTVQKQNDIHRAFKRELK
AKEPVISSALETVRIFLAEQPLEGLEKLYHESRELPPGERAQNVTRLLRRQADEVKTEWD
KLNLQSADWQKKIDEALERLQELQEAMDELDLKLRQAEAIKGSWQPVGDLLIDSLQDHLE
KIKVYRAEIAPLKENVDNVNDLAHQFTSTEIQLSPYSLSRLEDLNERWKLLQVTIEERIR
HLHEAHRDFGPTSQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLA
DLNNVRFSAYRTAMKLRRLQKALCLDLLSLSSACDALDQHNLKQNDQPMDILQIINCLTT
IYDRLEQEHNSLVNVPLCVDMCLNWLLNVYDTGRTGKIRVLSFKTGIISLCKAHLEDKYR
YLFKQVASPTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEI
EAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDI
CQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLP
VQTVLEGDNMETPASSPQLSHDDTHSRIEHYASRLAEMENTNGTYLNDSISPNESIDDEH
LLIQHYCQSLNQESPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKK
QHENKGLSPLPSPPEMMPISPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQ
LHRLRQLLEQPQVDAKVNGTTQSSPPTSLQRSDSNQPMLLRVVGSQTSESMGEDDLLSPP
QDTSTGLEEVMEQLNNSFPSTRG
| Protein Alignment to Mouse |
sp|P11531|DMD_MOUSE Dystrophin OS=Mus musculus GN=Dmd PE=1 SV=3
MGI:94909 Dmd dystrophin, muscular dystrophy (Chr X)
Length = 3678
Score = 5084 (1794.7 bits), Expect = 0., P = 0.
Identities = 988/1221 (80%), Positives = 1051/1221 (86%)
Query: 16 KETTISKQEMPSSLLLEVPALAEFNKAWADLTDWLSLLDRVIKSQIVTVGDLDEINDMII 75
KET ISK EMPSSLLLEVPALA+FN+AW +LTDWLSLLDRVIKSQ V VGDL++IN+MII
Sbjct: 2445 KETVISKLEMPSSLLLEVPALADFNRAWTELTDWLSLLDRVIKSQRVMVGDLEDINEMII 2504
Query: 76 KQKATIQDLEQRRPQLEELITAAQNLKNKTSNQEARTVITDRIEKIQNQWDEVQGHLHNR 135
KQKAT+QDLEQRRPQLEELITAAQNLKNKTSNQEART+ITDRIE+IQ QWDEVQ L NR
Sbjct: 2505 KQKATLQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQIQWDEVQEQLQNR 2564
Query: 136 RQQLHEMLKDSTQWLEARQEAEQVLECAKVKLASWKEISYTVEGLKKQNAELKQFAKELR 195
RQQL+EMLKDSTQWLEA++EAEQV+ + KL SWKE +TV+ ++K+ E KQ AK+LR
Sbjct: 2565 RQQLNEMLKDSTQWLEAKEEAEQVIGQVRGKLDSWKEGPHTVDAIQKKITETKQLAKDLR 2624
Query: 196 QWHINVDVANDLALKLLRDYSTDDTRKVELMTNNINDAWATINKRVGXXXXXXXXXXXXX 255
Q I+VDVANDLALKLLRDYS DDTRKV ++T NIN +W I+KRV
Sbjct: 2625 QRQISVDVANDLALKLLRDYSADDTRKVHMITENINTSWGNIHKRVSEQEAALEETHRLL 2684
Query: 256 QQFYLDLEKFLAWLTEAETTANVLQDATHKEKILEDAQGVRELMKQWQELQKEIETHTDI 315
QQF LDLEKFL+W+TEAETTANVLQDA+ KEK+LED++GVRELMK WQ+LQ EIETHTDI
Sbjct: 2685 QQFPLDLEKFLSWITEAETTANVLQDASRKEKLLEDSRGVRELMKPWQDLQGEIETHTDI 2744
Query: 316 FHSLDENGQKILRSLEGSDDAALLQRRLDNMNFRWSELRKKSLNIRSHLEASSDQWRRXX 375
+H+LDENGQKILRSLEGSD+A LLQRRLDNMNF+WSEL+KKSLNIRSHLEASSDQW+R
Sbjct: 2745 YHNLDENGQKILRSLEGSDEAPLLQRRLDNMNFKWSELQKKSLNIRSHLEASSDQWKRLH 2804
Query: 376 XXXXXXXXXXXXKEDELKQQEPIGGDLPTVQKQNDIHRAFKRELKAKEPVISSALETVRI 435
K+DEL +Q PIGGD P VQKQNDIHRAFKRELK KEPVI S LETVRI
Sbjct: 2805 LSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDIHRAFKRELKTKEPVIMSTLETVRI 2864
Query: 436 FLAEQPLEGLEKLYHESRELPPGERAQNVTRLLRRQADEVKTEWDKLNLQSADWQKKIDX 495
FL EQPLEGLEKLY E RELPP ERAQNVTRLLR+QA+EV EWDKLNL+SADWQ+KID
Sbjct: 2865 FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNAEWDKLNLRSADWQRKIDE 2924
Query: 496 XXXXXXXXXXXMDELDLKLRQAEAIKGSWQPVGDLLIDSLQDHLEKIKVYRAEIAPLKEN 555
DELDLKLRQAE IKGSWQPVGDLLIDSLQDHLEK+K R EIAPLKEN
Sbjct: 2925 ALERLQELQEAADELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKEN 2984
Query: 556 VDNVNDLAHQFTSTEIQLSPYSLSRLEDLNERWKLLQVTIEERIRHLHEAHRDFGPTSQH 615
V+ VNDLAHQ T+ IQLSPY+LS LEDLN RW+LLQV +E+R+R LHEAHRDFGP SQH
Sbjct: 2985 VNRVNDLAHQLTTLGIQLSPYNLSTLEDLNTRWRLLQVAVEDRVRQLHEAHRDFGPASQH 3044
Query: 616 FLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMK 675
FLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMK
Sbjct: 3045 FLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMK 3104
Query: 676 LRRLQKXXXXXXXXXXXXXXXXXQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNSLVNV 735
LRRLQK QHNLKQNDQPMDILQIINCLTTIYDRLEQEHN+LVNV
Sbjct: 3105 LRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNV 3164
Query: 736 PLCVDMCLNWLLNVYDTGRTGKIRVLSFKTGIISLCKAHLEDKYRYLFKQVASPTGFCDQ 795
PLCVDMCLNWLLNVYDTGRTG+IRVLSFKTGIISLCKAHLEDKYRYLFKQVAS TGFCDQ
Sbjct: 3165 PLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQ 3224
Query: 796 RRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQS 855
RRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQS
Sbjct: 3225 RRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQS 3284
Query: 856 MVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHK 915
MVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHK
Sbjct: 3285 MVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHK 3344
Query: 916 MHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETP-- 973
MHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETP
Sbjct: 3345 MHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVT 3404
Query: 974 -----------ASSPQLSHDDTHSRIEHYASRLAEMENTNGTYLNDSISPNESIDDEHLL 1022
ASSPQLSHDDTHSRIEHYASRLAEMEN+NG+YLNDSISPNESIDDEHLL
Sbjct: 3405 LINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLL 3464
Query: 1023 IQHYCQSLNQESPLSQPRSPAQXXXXXXXXXXXXXXXXXADLEEENRNLQAEYDRLKKQH 1082
IQHYCQSLNQ+SPLSQPRSPAQ ADLEEENRNLQAEYDRLK+QH
Sbjct: 3465 IQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQH 3524
Query: 1083 ENKGXXXXXXXXXXXXXXXXXXRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLH 1142
E+KG RDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLH
Sbjct: 3525 EHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLH 3584
Query: 1143 RLRQLLEQPQVDAKVNGTTQSSPPTSLQRSDSNQPMLLRVVGSQTSESMGEDDLLSPPQD 1202
RLRQLLEQPQ +AKVNGTT SSP TSLQRSDS+QPMLLRVVGSQTSESMGE+DLLSPPQD
Sbjct: 3585 RLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSESMGEEDLLSPPQD 3644
Query: 1203 TSTGLEEVMEQLNNSFPSTRG 1223
TSTGLEEVMEQLNNSFPS+RG
Sbjct: 3645 TSTGLEEVMEQLNNSFPSSRG 3665
Score = 173 (66.0 bits), Expect = 1.4e-05, Sum P(4) = 1.4e-05
Identities = 74/299 (24%), Positives = 133/299 (44%)
Query: 17 ETTISKQEMPSSLLLEVPALAEFNKAWADLTDWLSLLDRVIKSQIVTVGDLDEINDMIIK 76
+ T KQ++ L L E N LT+WL+ D + + G ++ +
Sbjct: 1560 KVTERKQQLEKCLKLSRKMRKEMNV----LTEWLAATDTELTKRSAVEGMPSNLDSEVAW 1615
Query: 77 QKATIQDLEQRRPQLEELITAAQNLKNKTSNQEARTVITDRIEKIQNQWDEVQGHLHNRR 136
KAT +++E+++ L+ + ++LK +E T++ D++ + + W V +R
Sbjct: 1616 GKATQKEIEKQKAHLKSVTELGESLKMVLGKKE--TLVEDKLSLLNSNWIAVT----SRV 1669
Query: 137 QQLHEMLKDSTQWLEA-RQEAEQVLECAKVKLASWKEISYTVEGLKKQNAE--LKQFAKE 193
++ +L + + +E Q EQ+ + + E+ E K Q E LK+ E
Sbjct: 1670 EEWLNLLLEYQKHMETFDQNIEQITKW----IIHADELLDESEKKKPQQKEDILKRLKAE 1725
Query: 194 LRQWHINVDVANDLALKLLRDYSTDDTRKV-ELMTNNINDAWATINKRVGXXXXXXXXXX 252
+ VD D A KL+ + D RKV E + +N +A I+ R+
Sbjct: 1726 MNDMRPKVDSTRDQAAKLMANRG-DHCRKVVEPQISELNRRFAAISHRI--KTGKASIPL 1782
Query: 253 XXXQQFYLDLEKFLAWLTEAETTANV-LQDATHKEKILEDAQG-VRELMKQWQELQKEI 309
+QF D++K L L EAE V L++ + + ED +G V EL+++ LQ+ I
Sbjct: 1783 KELEQFNSDIQKLLEPL-EAEIQQGVNLKEEDFNKDMSEDNEGTVNELLQRGDNLQQRI 1840
Score = 164 (62.8 bits), Expect = 7.0e-05, Sum P(4) = 7.0e-05
Identities = 71/354 (20%), Positives = 147/354 (41%)
Query: 20 ISKQEMPSSLLLE--VPALAEFNKAWADLTDWLSLLDRVIKSQIVTVGDLDEINDMIIKQ 77
+S Q + S LE + L +F L W++ +D +K + +GD + + + +
Sbjct: 1034 LSSQLVESCQKLEEHMNKLRKFQNHIKTLQKWMAEVDVFLKEEWPALGDAEILKKQLKQC 1093
Query: 78 KATIQDLEQRRPQLEELITAAQNLKNKTSNQEARTVITDRIEKIQNQWDEVQGHLHNRRQ 137
+ + D++ +P L + Q +K++ + A + T+ + ++ QWD + ++ R++
Sbjct: 1094 RLLVGDIQTIQPSLNSVNEGGQKIKSEAELEFASRLETE-LRELNTQWDHICRQVYTRKE 1152
Query: 138 QLHEMLKDSTQWLEARQEAEQVLECAKVKLASWKEISY-TVEGLKKQNAELKQFAKELRQ 196
L L + + E + + A+ + ++ Y T + L+ E+K+ +E Q
Sbjct: 1153 ALKAGLDKTVSLQKDLSEMHEWMTQAEEEYLE-RDFEYKTPDELQTAVEEMKRAKEEALQ 1211
Query: 197 WHINVDVANDLALKLLRDY--STDDTRKVELMTNNINDAWATINKRVGXXXXXXXXXXXX 254
V + + ++ S + K EL T N W + R+
Sbjct: 1212 KETKVKLLTETVNSVIAHAPPSAQEALKKELETLTTNYQW--LCTRLNGKCKTLEEVWAC 1269
Query: 255 XQQFYLDLEKFLAWLTEAETTANVLQDA-THKEKILEDAQGVRELMKQWQELQKEIETHT 313
+ LEK WL E E +++ E+I E + + LM +E +I
Sbjct: 1270 WHELLSYLEKANKWLNEVELKLKTMENVPAGPEEITEVLESLENLMHHSEENPNQIRL-- 1327
Query: 314 DIFHSLDENGQKILRSLEGSDDAALLQRRLDNMNFRWSELRKKSLNIRSHLEAS 367
+ +L + G ++ D+ L+ L+ N RW EL ++++ + LE S
Sbjct: 1328 -LAQTLTDGG--VM------DE--LINEELETFNSRWRELHEEAVRKQKLLEQS 1370
Score = 149 (57.5 bits), Expect = 2.3e-06, P = 2.3e-06
Identities = 123/629 (19%), Positives = 243/629 (38%)
Query: 16 KET-TISKQEMPSSLLLEVPALAEFNKAWADLTDWLSLLDRVIKSQIVTVGDLDEI--ND 72
+ET ++ ++MP + VP+ + + + LS +D ++ + + D +++ +
Sbjct: 1981 EETMVVTTEDMPLDVSY-VPST--YLTEISHILQALSEVDHLLNTPELCAKDFEDLFKQE 2037
Query: 73 MIIKQ-KATIQDLEQRRPQLEELITAA-QNLKN--KTSNQEARTVITDRIEKIQNQWDEV 128
+K K +Q + R + + TAA Q+ + K QEA + + EK+ + E
Sbjct: 2038 ESLKNIKDNLQQISGRIDIIHKKKTAALQSATSMEKVKVQEAVAQMDFQGEKLHRMYKER 2097
Query: 129 QGHLHN---RRQQLHEMLKDSTQWLEARQEAEQVLECAKVKLASWKEISYTVEGLKKQNA 185
QG + + H +K QWL E EQ + + +W+ Y
Sbjct: 2098 QGRFDRSVEKWRHFHYDMKVFNQWLN---EVEQFFKKTQ-NPENWEHAKY--------KW 2145
Query: 186 ELKQFAKELRQWHINVDVANDLALKLLRDYSTDDTRKVELMTNNINDAWATINKRVGXXX 245
LK+ + Q V N ++++ S D ++ +++ W I K +
Sbjct: 2146 YLKELQDGIGQRQAVVRTLNATGEEIIQQSSKTDVNILQEKLGSLSLRWHDICKELAERR 2205
Query: 246 XXXXXXXXXXQQFYLDLEKFLAWLTEAETTANVLQDATHKEKILEDAQGVRELMKQWQEL 305
+F DL +F+ WL EA+ A T L D Q ++E ++Q + L
Sbjct: 2206 KRIEEQKNVLSEFQRDLNEFVLWLEEADNIA-----ITP----LGDEQQLKEQLEQVKLL 2256
Query: 306 QKEIETHTDIFHSLDENGQKILRSLE-GSDDAALLQRRLDNMNFRWSELRKKSLNIRSHL 364
+E+ I L+E G +L S ++ L+++L N +W ++ + + L
Sbjct: 2257 AEELPLRQGILKQLNETGGAVLVSAPIRPEEQDKLEKKLKQTNLQWIKVSRALPEKQGEL 2316
Query: 365 EASSDQWRRXXXXXXXXXXXXXXKEDELK--QQEPIGG--DLPTVQ-----KQNDIHRAF 415
E +R+ ++L+ Q G D+ ++ KQ D+ R
Sbjct: 2317 EVHLKDFRQLEEQLDHLLLWLSPIRNQLEIYNQPSQAGPFDIKEIEVTVHGKQADVERLL 2376
Query: 416 KR--ELKAKEPVISSALETVRIFLAEQPLEGLEKLYHESRELPP---------GERAQNV 464
+ L ++P + +E E + L E R P G A
Sbjct: 2377 SKGQHLYKEKPSTQPVKRKLEDLRSEW--EAVNHLLRELRTKQPDRAPGLSTTGASASQT 2434
Query: 465 TRLLRRQADEVKTEWDKLNLQSADWQK--KIDXXXXXXXXXXXXMDELDLKLRQAEAIKG 522
L+ + +T KL + S+ + + + LD ++ + G
Sbjct: 2435 VTLVTQSVVTKETVISKLEMPSSLLLEVPALADFNRAWTELTDWLSLLDRVIKSQRVMVG 2494
Query: 523 SWQPVGDLLID---SLQDHLEKIKVYRAEIAPLKENVDNVNDLAHQFTSTEIQLSPYSLS 579
+ + +++I +LQD LE+ + E+ +N+ N ++Q T I
Sbjct: 2495 DLEDINEMIIKQKATLQD-LEQRRPQLEELITAAQNLKNKT--SNQEARTIIT------D 2545
Query: 580 RLEDLNERWKLLQVTIEERIRHLHEAHRD 608
R+E + +W +Q ++ R + L+E +D
Sbjct: 2546 RIERIQIQWDEVQEQLQNRRQQLNEMLKD 2574
Score = 148 (57.2 bits), Expect = 9.6e-06, Sum P(3) = 9.6e-06
Identities = 64/340 (18%), Positives = 136/340 (40%)
Query: 23 QEMPSSLLLEVPALAEFNKAWADLTDWLSLLDRVIKSQIVTVGDLDEINDMIIKQKATIQ 82
+ + SSL+ L + A ++ WL + +++Q D++E+ + + +
Sbjct: 330 KSLDSSLMETEVNLDSYQTALEEVLSWLLSAEDTLRAQGEISNDVEEVKEQFHAHEGFMM 389
Query: 83 DLEQRRPQLEELITAAQNL--KNKTSNQEARTVITDRIEKIQNQWDEVQGHLHNRRQQLH 140
DL + + ++ L K K S E V +++ + ++W+ ++ ++ +LH
Sbjct: 390 DLTSHQGLVGNVLQLGSQLVGKGKLSEDEEAEV-QEQMNLLNSRWECLRVASMEKQSKLH 448
Query: 141 EMLKDSTQWLEARQEAEQVLECAKVKLASWKEISY--TVEGLKKQNAELKQFAKELRQWH 198
++L D + +E + L + + +E + +E LK Q + K ++L Q
Sbjct: 449 KVLMDLQN--QKLKELDDWLTKTEERTKKMEEEPFGPDLEDLKCQVQQHKVLQEDLEQEQ 506
Query: 199 INVDVANDLALKLLRDYSTDD--TRKVELMTNNINDAWATINKRVGXXXXXXXXXXXXXQ 256
+ V+ + + + D S+ D T +E + D WA I + Q
Sbjct: 507 VRVNSLTHMVVVV--DESSGDHATAALEEQLKVLGDRWANICRWTEDRWIVLQDILLKWQ 564
Query: 257 QFYLDLEKFLAWLTEAETTANVLQDATHKEKILEDAQGVRELMKQWQELQKEIETHTDIF 316
F + F WL+E E +Q + K D + + + L+ ++E
Sbjct: 565 HFTEEQCLFSTWLSEKEDAMKNIQTSGFK-----DQNEMMSSLHKISTLKIDLEKKKPTM 619
Query: 317 HSLDENGQKILRSLEGSDDAALLQRRLDNMNFRWSELRKK 356
L Q +L +L+ ++ ++N RW L +K
Sbjct: 620 EKLSSLNQDLLSALKNKSVTQKMEIWMENFAQRWDNLTQK 659
Score = 147 (56.8 bits), Expect = 0.0014, Sum P(3) = 0.0014
Identities = 93/496 (18%), Positives = 201/496 (40%)
Query: 54 DRVIKSQIVTVGDLDEINDMIIKQKATIQDLEQRRPQLEELITAAQNLKNKTSNQEARTV 113
+ ++K+Q T+ + I + K + L +PQ+E+L Q+L+ K Q +
Sbjct: 852 ENLLKTQSTTLSEPTAIKSQLKICKDEVNRLSALQPQIEQL--KIQSLQLKEKGQGPMFL 909
Query: 114 ITDRIEKIQNQWDEVQGHLHNRRQQLHEMLKD--STQWLEARQEAEQVLECAKVKLASWK 171
D + N ++ + + + ++L + ++ E ++ ++ KL S
Sbjct: 910 DADFVA-FTNHFNHIFDGVRAKEKELQTIFDTLPPMRYQETMSSIRTWIQQSESKL-SVP 967
Query: 172 EISYT-VEGLKKQNAELKQFAKELRQWHINVDVANDLALKLLRDYSTDDTRKVELMTNNI 230
+S T E ++++ +L+ L++ + +D ++ + ++ +K I
Sbjct: 968 YLSVTEYEIMEERLGKLQALQSSLKEQQNGFNYLSDTVKEMAKKAPSEICQKYLSEFEEI 1027
Query: 231 NDAWATINKRVGXXXXXXXXXXXXXQQFYLDLEKFLAWLTEAETTANVLQDATHKEKILE 290
W ++ ++ ++F ++ W+ E + L++ + L
Sbjct: 1028 EGHWKKLSSQLVESCQKLEEHMNKLRKFQNHIKTLQKWMAEVDV---FLKE---EWPALG 1081
Query: 291 DAQGVRELMKQWQELQKEIETHTDIFHSLDENGQKILRSLEGSDDAALLQRRLDNMNFRW 350
DA+ +++ +KQ + L +I+T +S++E GQKI E + A+ L+ L +N +W
Sbjct: 1082 DAEILKKQLKQCRLLVGDIQTIQPSLNSVNEGGQKIKSEAE-LEFASRLETELRELNTQW 1140
Query: 351 SELRKKSLNIRSHLEASSDQWRRXXXXXXXXXXXXXXKEDELKQQE---PIGGDLPTVQK 407
+ ++ + L+A D+ E+E +++ +L T +
Sbjct: 1141 DHICRQVYTRKEALKAGLDKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQTAVE 1200
Query: 408 QNDIHRAFKRELKAKEPVISSALETVRIFLAEQPLEGLEKLYHESRELPPGERAQNVTRL 467
+ + RA K E KE + ETV +A P E L E L N L
Sbjct: 1201 E--MKRA-KEEALQKETKVKLLTETVNSVIAHAPPSAQEALKKELETL-----TTNYQWL 1252
Query: 468 LRRQADEVKTEWDKLNLQSADWQKKIDXXXXXXXXXXXXMDELDLKLRQAEAIKGSWQPV 527
R + KT L A W + + ++E++LKL+ E + + +
Sbjct: 1253 CTRLNGKCKT----LEEVWACWHELLSYLEKANKW----LNEVELKLKTMENVPAGPEEI 1304
Query: 528 GDLL--IDSLQDHLEK 541
++L +++L H E+
Sbjct: 1305 TEVLESLENLMHHSEE 1320
Score = 117 (46.2 bits), Expect = 2.0, Sum P(4) = 0.86
Identities = 84/487 (17%), Positives = 185/487 (37%)
Query: 45 DLTDWLSLLDRVIKSQIVTVGDLD-EINDMIIKQKATIQDLEQRRPQLEELITAAQNLKN 103
+L W++ + V++S V + I+D+ K A ++ ++ +L++ +AQ L
Sbjct: 732 ELHSWITRSEAVLQSSEFAVYRKEGNISDLQEKVNAIAREKAEKFRKLQDASRSAQALVE 791
Query: 104 KTSNQEARTV-ITDRIEKIQNQWDEVQGHLHNRRQQLHEMLKDSTQWLEARQEAEQVLEC 162
+ +N+ I E++ ++W E L R L E + + Q+ EQ+
Sbjct: 792 QMANEGVNAESIRQASEQLNSRWTEFCQLLSERVNWL-EYQTNIITFYNQLQQLEQMTTT 850
Query: 163 AKVKLASWKEISYTVEGLKKQNAELKQFAKELRQWHINVDVANDLALKLLRDYSTDDTRK 222
A+ L + +K Q K L ++ +L+L
Sbjct: 851 AENLLKTQSTTLSEPTAIKSQLKICKDEVNRLSALQPQIEQLKIQSLQLKEKGQGPMFLD 910
Query: 223 VELM--TNNINDAWATINKRVGXXXXXXXXXXXXXQQFYLDLEKFLAWLTEAETTANVLQ 280
+ + TN+ N + + R ++ + W+ ++E+ +V
Sbjct: 911 ADFVAFTNHFNHIFDGV--RAKEKELQTIFDTLPPMRYQETMSSIRTWIQQSESKLSVPY 968
Query: 281 DATHKEKILEDAQGVRELMKQWQELQKEIETHTDIFHSLDENGQKILRSLEGSDDAALLQ 340
+ + +I+E+ G + Q LQ ++ + F+ L + +++ + S+
Sbjct: 969 LSVTEYEIMEERLG------KLQALQSSLKEQQNGFNYLSDTVKEMAKKAP-SEICQKYL 1021
Query: 341 RRLDNMNFRWSELRKKSLNIRSHLEASSDQWRRXXXXXXXXXXXXXXKEDELKQQEPIGG 400
+ + W +L + + LE ++ R+ + LK++ P G
Sbjct: 1022 SEFEEIEGHWKKLSSQLVESCQKLEEHMNKLRKFQNHIKTLQKWMAEVDVFLKEEWPALG 1081
Query: 401 DLPTVQKQNDIHRAFKRELKAKEPVISSALETVRIFLAEQPLEGLEKLYHESRELPPGER 460
D ++KQ R +++ +P ++S E + +E LE +L E REL +
Sbjct: 1082 DAEILKKQLKQCRLLVGDIQTIQPSLNSVNEGGQKIKSEAELEFASRLETELREL--NTQ 1139
Query: 461 AQNVTRLLRRQADEVKTEWDK-LNLQSA-----DWQKKIDXXXXXXXXXXXXMDELDLKL 514
++ R + + + +K DK ++LQ +W + + DEL +
Sbjct: 1140 WDHICRQVYTRKEALKAGLDKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQTAV 1199
Query: 515 RQAEAIK 521
+ + K
Sbjct: 1200 EEMKRAK 1206
Score = 115 (45.5 bits), Expect = 0.073, Sum P(4) = 0.071
Identities = 41/206 (19%), Positives = 87/206 (42%)
Query: 262 LEKFLAWLTEAETTANVLQDATHKEKILEDAQGVRELMKQWQELQKEIETHTDIFHSLDE 321
LE+ L+WL AE T + +I D + V+E + ++ +H + ++ +
Sbjct: 350 LEEVLSWLLSAEDTLRA------QGEISNDVEEVKEQFHAHEGFMMDLTSHQGLVGNVLQ 403
Query: 322 NGQKIL-RSLEGSDDAALLQRRLDNMNFRWSELRKKSLNIRSHLEASSDQWRRXXXXXXX 380
G +++ + D+ A +Q +++ +N RW LR S+ +S L +
Sbjct: 404 LGSQLVGKGKLSEDEEAEVQEQMNLLNSRWECLRVASMEKQSKLHKVLMDLQNQKLKELD 463
Query: 381 XXXXXXXKEDELKQQEPIGGDLPTVQKQNDIHRAFKRELKAKEPVISSALETVRIFLAEQ 440
+ + ++EP G DL ++ Q H+ + +L+ ++ ++S V +
Sbjct: 464 DWLTKTEERTKKMEEEPFGPDLEDLKCQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS 523
Query: 441 PLEGLEKLYHESRELPPGERAQNVTR 466
L + + L G+R N+ R
Sbjct: 524 GDHATAALEEQLKVL--GDRWANICR 547
Score = 109 (43.4 bits), Expect = 0.26, Sum P(4) = 0.23
Identities = 57/301 (18%), Positives = 116/301 (38%)
Query: 40 NKAWADLTDWLSLLD-RVIKSQIVTVG-DLDEINDMIIKQKATIQDLEQRRPQLEELITA 97
N+ +L DWL+ + R K + G DL+++ + + K +DLEQ + ++ L T
Sbjct: 456 NQKLKELDDWLTKTEERTKKMEEEPFGPDLEDLKCQVQQHKVLQEDLEQEQVRVNSL-TH 514
Query: 98 AQNLKNKTSNQEARTVITDRIEKIQNQWDEVQGHLHNRRQQLHEMLKDSTQWLEARQEAE 157
+ +++S A + ++++ + ++W + +R L ++L +W +E
Sbjct: 515 MVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWIVLQDIL---LKWQHFTEEQC 571
Query: 158 QVLECAKVKLASWKEISYTVEGLKKQNAELKQFAK------ELRQWHINVDVANDLALKL 211
K + K I G K QN + K +L + ++ + L L
Sbjct: 572 LFSTWLSEKEDAMKNIQ--TSGFKDQNEMMSSLHKISTLKIDLEKKKPTMEKLSSLNQDL 629
Query: 212 LRDYSTDD-TRKVELMTNNINDAWATINKRVGXXXXXXXXXXXXXQQFYLDLEKFLAWLT 270
L T+K+E+ N W + +++ Q L + +T
Sbjct: 630 LSALKNKSVTQKMEIWMENFAQRWDNLTQKLEKSSAQISQAVTTTQPS-LTQTTVMETVT 688
Query: 271 EAETTANVLQDATHKEKILEDAQGVRELMKQWQELQKEIETHTDIFHSLDENGQKILRSL 330
T ++ +E Q R++ EL+K ++ HS + +L+S
Sbjct: 689 MVTTREQIMVKHAQEELPPPPPQKKRQITVD-SELRKRLDVDITELHSWITRSEAVLQSS 747
Query: 331 E 331
E
Sbjct: 748 E 748
Score = 62 (26.9 bits), Expect = 5.0e-05, Sum P(4) = 5.0e-05
Identities = 12/44 (27%), Positives = 27/44 (61%)
Query: 514 LRQAEAIKGSWQPVGDLLIDS---LQDHLEKIKVYRAEIAPLKE 554
L + E I+G W+ + L++S L++H+ K++ ++ I L++
Sbjct: 1021 LSEFEEIEGHWKKLSSQLVESCQKLEEHMNKLRKFQNHIKTLQK 1064
Score = 59 (25.8 bits), Expect = 9.6e-06, Sum P(3) = 9.6e-06
Identities = 44/212 (20%), Positives = 88/212 (41%)
Query: 402 LPTVQKQNDIHRAFKRELKAKEPVISSALETVRIFLAEQPLEGLEKLYHESRELPPGER- 460
L ++K N + +LK E V + E + LE LE L H S E P R
Sbjct: 1274 LSYLEKANKWLNEVELKLKTMENVPAGPEEITEV------LESLENLMHHSEENPNQIRL 1327
Query: 461 -AQNVT------RLLRRQADEVKTEWDKLNLQSADWQKKIDXXXXXXXXXXXXMDELDLK 513
AQ +T L+ + + + W +L+ ++ QK ++ + +
Sbjct: 1328 LAQTLTDGGVMDELINEELETFNSRWRELHEEAVRKQKLLEQSIQSAQEIEKSLHLIQES 1387
Query: 514 LRQAEAIKGSWQPVGDLLIDSLQ--DHLEKIK--VYRAEIAPLKENVDNVNDLAHQFTST 569
L + ++ + D +D+ Q +KI+ + EI+ + N A+Q +
Sbjct: 1388 LEFIDKQLAAY--ITDK-VDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKDANQRVLS 1444
Query: 570 EIQLSPYSLSRLEDLNERWKLLQ--VTIEERI 599
+I ++ +L+D++ +++L Q E+R+
Sbjct: 1445 QIDVAQ---KKLQDVSMKFRLFQKPANFEQRL 1473
Score = 50 (22.7 bits), Expect = 7.4e-05, Sum P(3) = 7.4e-05
Identities = 12/71 (16%), Positives = 31/71 (43%)
Query: 535 LQDHLEKIKVYRAEIAPLKENVDNVNDLAHQFTS-TEIQLSPYSLSRLEDLNERWKLLQV 593
+++ L K++ ++ + + + ++D + ++ LS E++ WK L
Sbjct: 977 MEERLGKLQALQSSLKEQQNGFNYLSDTVKEMAKKAPSEICQKYLSEFEEIEGHWKKLSS 1036
Query: 594 TIEERIRHLHE 604
+ E + L E
Sbjct: 1037 QLVESCQKLEE 1047
Score = 48 (22.0 bits), Expect = 0.00012, Sum P(3) = 0.00012
Identities = 30/147 (20%), Positives = 57/147 (38%)
Query: 462 QNVTRLLRRQADEVKTEWDKLNLQSADWQKKIDXXXXXXXXXXXXMDELDLKLRQAEAIK 521
+ VT + R+ VK ++L +++I + EL + ++EA+
Sbjct: 685 ETVTMVTTREQIMVKHAQEELPPPPPQKKRQITVDSELRKRLDVDITELHSWITRSEAVL 744
Query: 522 GS-----WQPVGDLLIDSLQDHLEKIKVYRAE-IAPLKENVDNVNDLAHQFTSTEIQLSP 575
S ++ G+ I LQ+ + I +AE L++ + L Q + +
Sbjct: 745 QSSEFAVYRKEGN--ISDLQEKVNAIAREKAEKFRKLQDASRSAQALVEQMANEGVNAES 802
Query: 576 YSLSRLEDLNERWKLLQVTIEERIRHL 602
+ E LN RW + ER+ L
Sbjct: 803 IRQAS-EQLNSRWTEFCQLLSERVNWL 828
Score = 47 (21.6 bits), Expect = 0.97, Sum P(3) = 0.62
Identities = 63/337 (18%), Positives = 129/337 (38%)
Query: 280 QDATHKEKILEDA-QGVRELMKQWQELQKEIETHTDIFHSLDENGQKILRSLEGSDDAAL 338
++A K+K+LE + Q +E+ K +Q+ +E I L + + + +A
Sbjct: 1358 EEAVRKQKLLEQSIQSAQEIEKSLHLIQESLEF---IDKQLAAYITDKVDAAQMPQEAQK 1414
Query: 339 LQRRLDNMNFRWSELRK----KSLNIR--SHLEASSDQWRRXXXXXXXXXXXXXXKEDEL 392
+Q L + E++K K N R S ++ + + + E L
Sbjct: 1415 IQSDLTSHEISLEEMKKHNQGKDANQRVLSQIDVAQKKLQDVSMKFRLFQKPANF-EQRL 1473
Query: 393 KQQEPIGGDLPTVQKQNDIHRAFKRELKAKEPVISSALE-TVRIF--LAEQPLEGLEKLY 449
++ + I L V+ +H ++ VI S L V ++ L+E E +E +
Sbjct: 1474 EESKMI---LDEVK----MHLPALETKSVEQEVIQSQLSHCVNLYKSLSEVKSE-VEMVI 1525
Query: 450 HESRELPPGERAQNVTRLLRRQADEVKTEWDKLNLQSADWQKKIDXXXXXXXXXXXXMDE 509
R++ ++ +N L R +K +++L + + +++++ M+
Sbjct: 1526 KTGRQIVQKKQTENPKELDER-VTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNV 1584
Query: 510 LD--LKLRQAEAIKGSWQPVGDLLIDSLQDHLEKIKVYRAEIAPLKENVDNVNDLAHQFT 567
L L E K S + + +L + K + EI K ++ +V +L
Sbjct: 1585 LTEWLAATDTELTKRS---AVEGMPSNLDSEVAWGKATQKEIEKQKAHLKSVTELGESLK 1641
Query: 568 STEIQLSPYSLSRLEDLNERWKLLQVTIEERIRHLHE 604
+ +L LN W + +EE + L E
Sbjct: 1642 MVLGKKETLVEDKLSLLNSNWIAVTSRVEEWLNLLLE 1678
Score = 46 (21.3 bits), Expect = 9.6e-06, Sum P(3) = 9.6e-06
Identities = 18/64 (28%), Positives = 32/64 (50%)
Query: 1106 DAE-LIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQL-LEQPQVDAKVNGTTQS 1163
D E L+++ + L + K + + LED + E+ H LR+L +QP ++ T S
Sbjct: 2371 DVERLLSKGQHLYKEKPSTQPVKRKLEDLRSEWEAVNHLLRELRTKQPDRAPGLSTTGAS 2430
Query: 1164 SPPT 1167
+ T
Sbjct: 2431 ASQT 2434
Score = 44 (20.5 bits), Expect = 7.0e-05, Sum P(4) = 7.0e-05
Identities = 20/92 (21%), Positives = 37/92 (40%)
Query: 480 DKLNLQSADW---QKKIDXXXXXXXXXXXXMDELDLKLRQAEAIKGSWQPVGDLLIDSL- 535
DKL+L +++W +++ M+ D + Q W D L+D
Sbjct: 1653 DKLSLLNSNWIAVTSRVEEWLNLLLEYQKHMETFDQNIEQIT----KWIIHADELLDESE 1708
Query: 536 ----QDHLEKIKVYRAEIAPLKENVDNVNDLA 563
Q + +K +AE+ ++ VD+ D A
Sbjct: 1709 KKKPQQKEDILKRLKAEMNDMRPKVDSTRDQA 1740
Score = 42 (19.8 bits), Expect = 1.4e-05, Sum P(4) = 1.4e-05
Identities = 12/45 (26%), Positives = 19/45 (42%)
Query: 469 RRQADEVKTEWDKLNLQSADWQKKIDXXXXXXXXXXXXMDELDLK 513
R++A E+ +W + Q+ D K +D DE LK
Sbjct: 1871 RKKALEISHQWYQYKRQADDLLKCLDEIEKKLASLPEPRDERKLK 1915
Score = 41 (19.5 bits), Expect = 4.2e-05, Sum P(4) = 4.2e-05
Identities = 17/57 (29%), Positives = 28/57 (49%)
Query: 1110 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQVDAKV-NGTTQSSP 1165
I ++ L + +G LE L+D +QLE QL L L + ++ N +Q+ P
Sbjct: 2303 IKVSRALPEKQGELEVH---LKDF-RQLEEQLDHLLLWLSPIRNQLEIYNQPSQAGP 2355
Score = 40 (19.1 bits), Expect = 5.3e-05, Sum P(4) = 5.3e-05
Identities = 9/35 (25%), Positives = 15/35 (42%)
Query: 711 ILQIINCLTTIYDRLEQEHNSLVNVPLCVDMCLNW 745
+ Q + T+ +LE + L+ VP D W
Sbjct: 2438 VTQSVVTKETVISKLEMPSSLLLEVPALADFNRAW 2472
Score = 40 (19.1 bits), Expect = 0.00045, Sum P(3) = 0.00045
Identities = 15/52 (28%), Positives = 23/52 (44%)
Query: 1114 KLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQVDAKVNGTTQSSP 1165
+LL + LE + I+ +N QL +L Q+ + K TT S P
Sbjct: 819 QLLSERVNWLEYQTNIITFYN-----QLQQLEQMTTTAENLLKTQSTTLSEP 865
Score = 39 (18.8 bits), Expect = 0.00056, Sum P(3) = 0.00056
Identities = 10/21 (47%), Positives = 13/21 (61%)
Query: 1130 LEDHNKQLESQLHRLRQLLEQ 1150
+E H K+L SQL Q LE+
Sbjct: 1027 IEGHWKKLSSQLVESCQKLEE 1047
Score = 38 (18.4 bits), Expect = 1.4e-05, Sum P(4) = 1.4e-05
Identities = 24/130 (18%), Positives = 52/130 (40%)
Query: 552 LKENVDNVN---DLAHQFTSTEIQLSPYSLSRLEDLNERWKLLQVTIE-ERIRHLHEAHR 607
+K+N+ ++ D+ H+ + +Q S + +E + + + Q+ + E++ +++ +
Sbjct: 2043 IKDNLQQISGRIDIIHKKKTAALQ----SATSMEKVKVQEAVAQMDFQGEKLHRMYKERQ 2098
Query: 608 DFGPTS----QHF-LSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADL 662
S +HF V W N+V + W+H K + L D
Sbjct: 2099 GRFDRSVEKWRHFHYDMKVFNQWL-----NEVEQFFKKTQNPENWEHAKYKWYLKELQDG 2153
Query: 663 NNVRFSAYRT 672
R + RT
Sbjct: 2154 IGQRQAVVRT 2163
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