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Gene Model: Maoa

NomenclatureGenomic Location
SymbolMaoaChromosome2
NameMonoamine oxidase ALinkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates2: 89 Mbp

Molecular Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Molecular Function Terms:

binding
   amine binding
      serotonin binding
   cofactor binding
      coenzyme binding
         flavin adenine dinucleotide binding

catalytic activity
   oxidoreductase activity
      oxidoreductase activity, acting on the CH-NH2 group of donors
         oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
            primary amine oxidase activity

Human Disease Association

Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.

Predicted Transcript
     1 TTTGAGAACAAGAGAAAGTGCTCTGGGATTCCCAGATGTTTTGATGTTTTTACCATCCTT
    61 GGGGGAGGCTTCTCTCGTCTGTCAGCAGCTAAGCTGTTATCTGAATCTGGACTTAAGGTT
   121 GTGGTTTTAGAAGCACGAGACAGAGTTGGTGGACGAACGCACACAATTAGGAACAAGCAA
   181 GTGAACTATGTAGATGTTGGCGGAGCCTACGTAGGGCCTACACAGAATCAAATTCTGCGA
   241 CTGGCTAAAGAACTTGGCATAGAAACATATAAAGTGGATGTAGATGATGCCGGGATCCTG
   301 CACACAAATGGGAAATCCTACCCGCTCTATGGCTTCTTTCCTTCAACATGGAATCCTTTC
   361 ACATACCTAGATTTTAACAATTTATGGAGAACAATGGATGAACTGGGGGAAAAGATACCT
   421 GCTGAAGCACCCTGGGATGCACCATTTGCTGAAAAACTGGACAAAATGACAATGAAAGAG
   481 TTTATTAACAAACATTGCTGGACAAAAGCTGCCAATGATTATGCTACTCTCTTTGTAAAT
   541 GTCAACATAACTTCTGAAACACATGAAGTCTCTGCCCTTTGGTTTCTTTGGTATGTGAAG
   601 TTATGTGGGGGAACAACACGGATCTTTTCTGTCACAAATGGAGGGCAGGAGAGGAAGTTT
   661 GTTGGGGGTTCTGGACAGATTTCAGAAAAGATCATGGAACTACTCAAGGACAATGTTAAA
   721 CTGGAGAGACCTGTAGTTCACATTGATCAGTCTGGTGACAGCATCATTGTGAAGACACTT
   781 AACCATGAGACTTATAAGGGCAGGTATGTGATCAGTGCCATTCCCCCAGTCTTAACCACA
   841 AAGATTCATTTCGAGCCAGCACTTCCTACTAAAAGAAACCAGTTAATCCAGCGCATTCCC
   901 ATGGGCTCTGTCATTAAATGCATGATGTACTACAAAGACGCCTTCTGGAAGAGGATGGGA
   961 TTTTGTGGTGCCATGATGATTGTGGATGAAGAGGCTCCTATTTCAGTAACCTTAGATGAC
  1021 ACTAAACCTGATGGGTCTGTGCCTGCCATTATGGGTTTCATCCTTGCAAGAAAGGCATTT
  1081 AGATTAGCAGAACTTAGCAAAGAAGAGAGGAAGAAAAGAATATGTGAACTGTATGCAAAA
  1141 GTGTTGGGATCAGAAGAAGCATTACATCCAGTACATTATGAAGAAAAAAACTGGGGTGCA
  1201 GAACAATATTCTGGCGGTTGCTATACAGCCTATTTTCCACCAGGCATTATGTCCCAATAC
  1261 GGAAGGATAATTCGTCAGCCAGCTGGAAGGATTTACTTTGCTGGCACTGAAACAGCTACA
  1321 CAGTGGAGTGGCTACATGGAAGGAGCCGTACAGGCTGGAGAGAGAGCTGCCAGAGAGATA
  1381 TTATGCAACATGGGAAAGATTTCAAAGAGTGACATTTGGCTAACAGAACCAGAATCAAAG
  1441 GATGTTCCAGCTCTCCCAATCACAACTACCTTTTTGGAAAGGAATTTACCATCTGTCACA
  1501 GGACTTCTGGTCCTTCTGGGATTTTCTTCCCTCTTCACTTCATTGGCTGCAGTTGGACTC
  1561 TTTGCTTACAAAAAGGGACTTATCCCCCGAGCA

Predicted Protein Product
FENKRKCSGIPRCFDVFTILGGGFSRLSAAKLLSESGLKVVVLEARDRVGGRTHTIRNKQ
VNYVDVGGAYVGPTQNQILRLAKELGIETYKVDVDDAGILHTNGKSYPLYGFFPSTWNPF
TYLDFNNLWRTMDELGEKIPAEAPWDAPFAEKLDKMTMKEFINKHCWTKAANDYATLFVN
VNITSETHEVSALWFLWYVKLCGGTTRIFSVTNGGQERKFVGGSGQISEKIMELLKDNVK
LERPVVHIDQSGDSIIVKTLNHETYKGRYVISAIPPVLTTKIHFEPALPTKRNQLIQRIP
MGSVIKCMMYYKDAFWKRMGFCGAMMIVDEEAPISVTLDDTKPDGSVPAIMGFILARKAF
RLAELSKEERKKRICELYAKVLGSEEALHPVHYEEKNWGAEQYSGGCYTAYFPPGIMSQY
GRIIRQPAGRIYFAGTETATQWSGYMEGAVQAGERAAREILCNMGKISKSDIWLTEPESK
DVPALPITTTFLERNLPSVTGLLVLLGFSSLFTSLAAVGLFAYKKGLIPRA
Protein Alignment to Mouse
sp|Q64133|AOFA_MOUSE Amine oxidase [flavin-containing] A OS=Mus musculus
            GN=Maoa PE=1 SV=3
      MGI:96915 Maoa monoamine oxidase A (Chr X)
        Length = 526

 Score = 1941 (688.3 bits), Expect = 3.1e-201, P = 3.1e-201
 Identities = 356/484 (73%), Positives = 421/484 (86%)

Query:    14 FDVFTILGGGFSRLSAAKLLSESGLKVVVLEARDRVGGRTHTIRNKQVNYVDVGGAYVGP 73
             FDV  ++GGG S L+AAKLLSE  + V+VLEARDRVGGRT+T+RN+ V +VDVGGAYVGP
Sbjct:    14 FDV-VVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGP 72

Query:    74 TQNQILRLAKELGIETYKVDVDDAGILHTNGKSYPLYGFFPSTWNPFTYLDFNNLWRTMD 133
             TQN+ILRL+KELGIETYKV+V++  + +  GK+YP  G FP  WNP  YLD+NNLWRTMD
Sbjct:    73 TQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMD 132

Query:   134 ELGEKIPAEAPWDAPFAEKLDKMTMKEFINKHCWTKAANDYATLFVNVNITSETHEVSAL 193
             ++G++IP +APW A  AE+ DK+TMK+ I+K CWTK A ++A LFVN+N+TSE HEVSAL
Sbjct:   133 DMGKEIPVDAPWQARHAEEWDKITMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSAL 192

Query:   194 WFLWYVKLCGGTTRIFSVTNGGQERKFVGGSGQISEKIMELLKDNVKLERPVVHIDQSGD 253
             WFLWYV+ CGGT+RIFSVTNGGQERKFVGGSGQISE+IM LL D VKL  PV +IDQ+ D
Sbjct:   193 WFLWYVRQCGGTSRIFSVTNGGQERKFVGGSGQISEQIMVLLGDKVKLSSPVTYIDQTDD 252

Query:   254 SIIVKTLNHETYKGRYVISAIPPVLTTKIHFEPALPTKRNQLIQRIPMGSVIKCMMYYKD 313
             +II++TLNHE Y+ +YVISAIPPVLT KIHF+P LP +RNQLIQR+PMG+VIKCM+YYK+
Sbjct:   253 NIIIETLNHEHYECKYVISAIPPVLTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKE 312

Query:   314 AFWKRMGFCGAMMIVDEEAPISVTLDDTKPDGSVPAIMGFILARKAFRLAELSKEERKKR 373
             AFWK+  +CG M+I DEEAPIS+TLDDTKPDGS+PAIMGFILARKA RLA+L K+ RK++
Sbjct:   313 AFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSMPAIMGFILARKAERLAKLHKDIRKRK 372

Query:   374 ICELYAKVLGSEEALHPVHYEEKNWGAEQYSGGCYTAYFPPGIMSQYGRIIRQPAGRIYF 433
             ICELYAKVLGS+EAL PVHYEEKNW  EQYSGGCYTAYFPPGIM+ YGR+IRQP GRIYF
Sbjct:   373 ICELYAKVLGSQEALSPVHYEEKNWCEEQYSGGCYTAYFPPGIMTLYGRVIRQPVGRIYF 432

Query:   434 AGTETATQWSGYMEGAVQAGERAAREILCNMGKISKSDIWLTEPESKDVPALPITTTFLE 493
             AGTETATQWSGYMEGAV+AGERAARE+L  +GK++K DIW+ EPESKDVPAL IT TFLE
Sbjct:   433 AGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVQEPESKDVPALEITHTFLE 492

Query:   494 RNLP 497
             RNLP
Sbjct:   493 RNLP 496