| Nomenclature | Genomic Location |
| Symbol | Gpi | Chromosome | X |
| Name | Glucose-6-phosphate isomerase | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | X: 33 Mbp |
| Molecular Function |
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Besides its role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine
and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic
factor (Neuroleukin) for spinal and sensory neurons.
D-glucose 6-phosphate = D-fructose 6-phosphate.
Molecular Function Terms:
binding
carbohydrate binding
sugar binding
monosaccharide binding
protein binding
receptor binding
cytokine activity
growth factor activity
catalytic activity
isomerase activity
intramolecular oxidoreductase activity
intramolecular oxidoreductase activity, interconverting aldoses and ketoses
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| Human Disease Association |
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Defects in GPI are the cause of hemolytic anemia non-spherocytic due to glucose phosphate isomerase
deficiency (HA-GPID) [MIM:613470]. It is a form of anemia in which there is no abnormal hemoglobin
or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Severe GPI deficiency can
be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
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1 ATGACTCTCTCGAGCGACGCGGCCTTCCAGAAGCTGAGGGAATGGCACAAGGCCCACGCC
61 GCCCAGCTCGTCCTCCGGCAGCTCTTCGACGCCGACAAGGATCGCTTCCGGAAGTTCAGC
121 TTGACTCTCAACACCGATCAGGGGGACATCCTGGTTGACTATTCGAAGAACCTCGTCACT
181 GAAGATGTCATGAAGCTGTTGATTGACGTGGCAAAATCCAGGGGCATTGAAAAAGCCCGA
241 GAGCAAATGTTCAGTGGGGAAAAGATCAACTTCACCGAGAACCGTGCCGTGCTCCACATC
301 GCTCTGAGGAATCGCTCCAACACGCCCATCTTAGTGGACGGCAAAGACGTGGTTCCGGAC
361 GTGAACAAAGTGCTGGAGAAGATGAAGGGTTTCTGCCAGAAAGTTCGCAGTGGGGACTGG
421 AAAGGCTACAGTGGGAAATCCATGACGGACGTGGTCAACGTTGGGATTGGCGGGTCAGAC
481 TTGGGCCCGCTGATGGTGACCGAAGCCCTGAAGCCGTACTCCAAGGGCGGCCCCCGCGTC
541 TGGTTTGTGTCCAACATCGACGGCACCCACATGGCCAAGACCCTGGCCGAGCTCAACCCG
601 GAGACAACGCTCTTCATCATTGCCTCCAAGACTTTCACCACTCAAGAGACCATCACCAAC
661 GCGGAGACGGCCAAGGAGTGGTTCCTTAAGGCAGCAAAAGATCCCGGTGCTGTGGCCAAG
721 CATTTCGTCGCTCTTTCCACCAATGGGCCTAAAGTGAAAGATTTTGGGATCGACACTCAG
781 AACATGTTCGAGTTTTGGGACTGGGTCGGGGGCCGCTATTCCTTGTGGTCGGCCATTGGC
841 CTCTCCATCGCCCTCCACATCGGTTATGACAATTTTGAGAAATTGCTTGCTGGAGCCCAC
901 TGGATGGACAACCACTTCCGCACGACTCCGCTGGAGAAGAACGTCCCCGTGGTGCTGGCC
961 ATGCTGGGCGTCTGGTACATCAACTGCTATGGGACCGAGACCCATGCGCTCCTGCCCTAC
1021 GACCAGTACATGCACCGCTTCGCAGCCTACTTCCAGCAGGGGGACATGGAATCCAACGGG
1081 AAGTACATCACCAAGAAGGGCACCCGGGTGAACTACAGCACCGGGCCCATCGTGTGGGGC
1141 GAGCCGGGAACCAACGGGCAGCATGCCTTCTACCAGCTCATCCACCAAGGAACGCGTATG
1201 ATTCCTTGCGACTTCCTCATCCCGGTCCAGACGCAGAACCCCATCCGGAACGGGCTGCAC
1261 CACAAGATCCTTCTGGCCAACTTCCTGGCCCAGACGGAGGCCTTGATGAAGGGCAAGACC
1321 ACCGAGGAAGCCCGCCAAGAGCTCCAGGCGGCCGGGATGAGCGGAGACGCCCTGGAGAAG
1381 CTCCTTCCCCACAAGGTCTTTGAAGGCAACCGCCCCACCAATTCCATTATGTTTACTAAG
1441 CTGAATCCATTCATCCTTGGAGCCTTAATTGCCATGTACGAACACAAGATCTTTGTTCAA
1501 GGCGTCGTGTGGGATATCAACAGCTACGACCAATGGGGGGTGGAGCTGGGGAAGCAGCTG
1561 GCCAAGAAGATCGAGCCGGAGTTGTCCTCGGACGCGCCCGTCACCTCCCACGACTCCTCC
1621 ACCAACGGCCTCATCGGCTTCATCCAGAAGCACCGGGCCTGA
| Predicted Protein Product |
MTLSSDAAFQKLREWHKAHAAQLVLRQLFDADKDRFRKFSLTLNTDQGDILVDYSKNLVT
EDVMKLLIDVAKSRGIEKAREQMFSGEKINFTENRAVLHIALRNRSNTPILVDGKDVVPD
VNKVLEKMKGFCQKVRSGDWKGYSGKSMTDVVNVGIGGSDLGPLMVTEALKPYSKGGPRV
WFVSNIDGTHMAKTLAELNPETTLFIIASKTFTTQETITNAETAKEWFLKAAKDPGAVAK
HFVALSTNGPKVKDFGIDTQNMFEFWDWVGGRYSLWSAIGLSIALHIGYDNFEKLLAGAH
WMDNHFRTTPLEKNVPVVLAMLGVWYINCYGTETHALLPYDQYMHRFAAYFQQGDMESNG
KYITKKGTRVNYSTGPIVWGEPGTNGQHAFYQLIHQGTRMIPCDFLIPVQTQNPIRNGLH
HKILLANFLAQTEALMKGKTTEEARQELQAAGMSGDALEKLLPHKVFEGNRPTNSIMFTK
LNPFILGALIAMYEHKIFVQGVVWDINSYDQWGVELGKQLAKKIEPELSSDAPVTSHDSS
TNGLIGFIQKHRA
| Protein Alignment to Mouse |
sp|P06745|G6PI_MOUSE Glucose-6-phosphate isomerase OS=Mus musculus GN=Gpi PE=1
SV=4
MGI:95797 Gpi1 glucose phosphate isomerase 1 (Chr 7)
Length = 558
Score = 2461 (871.4 bits), Expect = 2.5e-256, P = 2.5e-256
Identities = 450/550 (81%), Positives = 506/550 (92%)
Query: 3 LSSDAAFQKLREWHKAHAAQLVLRQLFDADKDRFRKFSLTLNTDQGDILVDYSKNLVTED 62
L+ + FQKL EWH+A++A L LR+LF+AD +RF FSL LNT+ G ILVDYSKNLV ++
Sbjct: 4 LTRNPQFQKLLEWHRANSANLKLRELFEADPERFNNFSLNLNTNHGHILVDYSKNLVNKE 63
Query: 63 VMKLLIDVAKSRGIEKAREQMFSGEKINFTENRAVLHIALRNRSNTPILVDGKDVVPDVN 122
VM++L+++AKSRG+E AR+ MFSG KIN+TENRAVLH+ALRNRSNTPI VDGKDV+P+VN
Sbjct: 64 VMQMLVELAKSRGVEAARDNMFSGSKINYTENRAVLHVALRNRSNTPIKVDGKDVMPEVN 123
Query: 123 KVLEKMKGFCQKVRSGDWKGYSGKSMTDVVNVGIGGSDLGPLMVTEALKPYSKGGPRVWF 182
+VL+KMK FCQ+VRSGDWKGY+GKS+TD++N+GIGGSDLGPLMVTEALKPYSKGGPRVWF
Sbjct: 124 RVLDKMKSFCQRVRSGDWKGYTGKSITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWF 183
Query: 183 VSNIDGTHMAKTLAELNPETTLFIIASKTFTTQETITNAETAKEWFLKAAKDPGAVAKHF 242
VSNIDGTH+AKTLA L+PET+LFIIASKTFTTQETITNAETAKEWFL+AAKDP AVAKHF
Sbjct: 184 VSNIDGTHIAKTLASLSPETSLFIIASKTFTTQETITNAETAKEWFLEAAKDPSAVAKHF 243
Query: 243 VALSTNGPKVKDFGIDTQNMFEFWDWVGGRYSLWSAIGLSIALHIGYDNFEKLLAGAHWM 302
VALSTN KVK+FGID QNMFEFWDWVGGRYSLWSAIGLSIALH+G+D+FE+LL+GAHWM
Sbjct: 244 VALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWM 303
Query: 303 DNHFRTTPLEKNVPVVLAMLGVWYINCYGTETHALLPYDQYMHRFAAYFQQGDMESNGKY 362
D HF TPLEKN PV+LA+LG+WYINCYG ETHALLPYDQYMHRFAAYFQQGDMESNGKY
Sbjct: 304 DQHFLKTPLEKNAPVLLALLGIWYINCYGCETHALLPYDQYMHRFAAYFQQGDMESNGKY 363
Query: 363 ITKKGTRVNYSTGPIVWGEPGTNGQHAFYQLIHQGTRMIPCDFLIPVQTQNPIRNGLHHK 422
ITK G RV++ TGPIVWGEPGTNGQHAFYQLIHQGT+MIPCDFLIPVQTQ+PIR GLHHK
Sbjct: 364 ITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHK 423
Query: 423 ILLANFLAQTEALMKGKTTEEARQELQAAGMSGDALEKLLPHKVFEGNRPTNSIMFTKLN 482
ILLANFLAQTEALMKGK EEAR+ELQAAG S + LEKLLPHKVFEGNRPTNSI+FTKL
Sbjct: 424 ILLANFLAQTEALMKGKLPEEARKELQAAGKSPEDLEKLLPHKVFEGNRPTNSIVFTKLT 483
Query: 483 PFILGALIAMYEHKIFVQGVVWDINSYDQWGVELGKQLAKKIEPELSSDAPVTSHDSSTN 542
PFILGALIAMYEHKIFVQG++WDINS+DQWGVELGKQLAKKIEPEL + VTSHDSSTN
Sbjct: 484 PFILGALIAMYEHKIFVQGIMWDINSFDQWGVELGKQLAKKIEPELEGSSAVTSHDSSTN 543
Query: 543 GLIGFIQKHR 552
GLI FI++ R
Sbjct: 544 GLISFIKQQR 553
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