| Nomenclature | Genomic Location |
| Symbol | Aco2 | Chromosome | 2 |
| Name | Aconitate hydratase, mitochondrial | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | 2: 87 Mbp |
| Molecular Function |
|
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Citrate = isocitrate.
Molecular Function Terms:
binding
ion binding
cation binding
metal ion binding
metal cluster binding
iron-sulfur cluster binding
catalytic activity
lyase activity
carbon-oxygen lyase activity
hydro-lyase activity
|
| Human Disease Association |
|
No disease association.
|
...................................ATGGCGCCGTACTGCGTCCTGGCGG
26 CTCGGCTGCGGCATGCCCTGAATGGTGGGATACGGCGCTACCATGTTGCATCTGTTCTAT
86 GCCAGCGGGCCAAGGTGGCCATGAGCCACTTTGAGCCTAATGAATACATAAACTATGAAA
146 AGTTGGAGAAGAACATCAACATCGTCCGTAAGAGGCTTGACCGTCCTCTGACCTTATCTG
206 AGAAGATTGTATATGGACACCTGGATGACCCAGCAAAACAGGAGATTGAGAGAGGCAAGA
266 CCTATTTGCGCCTGCGGCCTGACCGTGTGGCCATGCAGGATGCCACTGCTCAGATGGCAA
326 TGCTACAGTTCATCAGCAGCGGGCTGCCGAAAGTGGCCGTGCCTTCCACCATCCACTGTG
386 ATCACCTCATAGAAGCTCAGTCAGGTGGTGAAAAGGATCTTCGAAGAGCCAAGGACATAA
446 ACCAGGAGGTGTACAACTTTCTATCGACGGCTGGTGCCAAGTATGGAGTGGGATTCTGGA
506 AACCTGGATCAGGAATCATTCACCAGATCATTCTGGAGAACTACTCCTACCCTGGGGTTA
566 TGTTGATTGGCACAGACTCACACACCCCCAACGGAGGTGGCTTGGGAGGAATCTGCATTG
626 GAGTGGGTGGAGCTGATGCTGTAGATGTCATGGCAGGAATCCCTTGGGAGCTCAAATGCC
686 CAAAGGTTATTGGTGTAAAACTAACTGGGAAGCTTTCTGGCTGGAGTTCTCCTAAAGATG
746 TGATCCTGAAAGTGGCTGGCATCCTCACTGTTAAGGGTGGAACAGGTGCCATCATCGAAT
806 ACCATGGGCCTGGTGTGGATTCGATCTCTTGCACTGGAATGGCAACAATCTGTAACATGG
866 GGGCTGAAATTGGAGCTACCACCTCAGTCTTCCCTTACAACACCCGGATGAAGAAATACC
926 TGGGCAAGACTGGGCGAGCTGACATAGCTGCACTGGCAGATGAGTTCCAGCAATACTTGG
986 TGCCAGATGCTGGTTGTCAGTACGACCAGGTGATAGAAATCAACCTCAGTGAGCTGAAGC
1046 CACATATCAATGGACCTTTCACACCAGACCTGGCGCACCCTGTGTCAGATGTTGGTGCTG
1106 TGGCAGAAAAGGAGGGCTGGCCTGTTGATATCAGAGTTGGCCTGATTGGCAGCTGCACCA
1166 ACTCCAGCTATGAGGACATGGGACGCTCTGCAGCAGTGGCAAAGCAGGCACTGGCGCATG
1226 GGTTGAAGTGCAAATCAAAGTTCACAATCACACCAGGCTCAGAGCAAATCCGTGCCACCA
1286 TTGAAAGGGACGGTTACGCGCAAATCCTGCGAGACGTTGGAGGGCTGATTCTTGCCAATG
1346 CTTGTGGGCCATGCATTGGCCAGTGGGACAGGAAGGACATAAAGAAAGGAGAGAAAAACA
1406 CAATAGTTACGTCTTACAACCGGAATTTCACAGGTCGCAATGATGCCAACCCAGAGACTC
1466 ACGCGTTTGTGACCTCCCCAGAGATTGTCACAGCCCTGTCCATTGCTGGTACTCTAAAAT
1526 TTAACCCTGAGACAGATTTCCTGACAGGAGCAGATGGGAAGAAGTTTAAACTAGAAGCAC
1586 CTGATGCAGATGAGCTGCCTAGGCTGGATTTTGACCCAGGCCAGGACACGTATCAGTACC
1646 CTCCCAAGGATGGCAGTGGGCAGCATGTGGATGTGAGCCCCACCAGCCAGCGCCTCCAGC
1706 TTCTTGAGCCCTTTGATAAGTGGGATGGCAAGGATCTAGAAGACATGCTGATCCTCATCA
1766 AGGTAAAAGGGAAATGCACCACTGATCATATTTCTGCTGCTGGACCATGGCTCAAATTCC
1826 GTGGCCATTTGGACAACATCTCCAACAACCTGCTCATTGGCGCTATCAACATTGAAAATG
1886 GCAAAGCCAACTCTGTGAGGAATGCACTAACCCAGGAGTTTGGGCCTGTCCCAGACACAG
1946 CCCGTTACTATAAGAAAATGGGTGTCAAATGGGCAGTTATTGGGGATGAAAACTATGGTG
2006 AGGGATCAAGCCGAGAGCACGCAGCCTTGGAGCCACGTCACTTAGGGGGCAGGGTGATCA
2066 TCACCAAGAGCTTTGCCAGGATCCACGAAACCAACCTGAAGAAGCAAGGTCTGCTGCCTC
2126 TTACTTTTGCGGATCCAGCAGACTACAACAAGATTCATCCTGTGGACAAGCTGAGCATCG
2186 TGGGGCTGGCAGACTTTGCTCCTGGAAAGCCTCTGAAATGCATCATCAAGCATCCCAACG
2246 GGAGCCAAGAAACAATCATGTTGAACCACACCTTCAACGAGTCGCAGATCGAGTGGTTCC
2306 AGGCTGGCAGTGCCCTGAACAGAATGAAGGAGCTGCAGCAGAAATCAAGCTAA
| Predicted Protein Product |
MAPYCVLAARLRHALNGGIRRYHVASVLCQRAKVAMSHFEPNEYINYEKLEKNINIVRKR
LDRPLTLSEKIVYGHLDDPAKQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKV
AVPSTIHCDHLIEAQSGGEKDLRRAKDINQEVYNFLSTAGAKYGVGFWKPGSGIIHQIIL
ENYSYPGVMLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGKL
SGWSSPKDVILKVAGILTVKGGTGAIIEYHGPGVDSISCTGMATICNMGAEIGATTSVFP
YNTRMKKYLGKTGRADIAALADEFQQYLVPDAGCQYDQVIEINLSELKPHINGPFTPDLA
HPVSDVGAVAEKEGWPVDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSKFTITP
GSEQIRATIERDGYAQILRDVGGLILANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTG
RNDANPETHAFVTSPEIVTALSIAGTLKFNPETDFLTGADGKKFKLEAPDADELPRLDFD
PGQDTYQYPPKDGSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDMLILIKVKGKCTTDHIS
AAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNALTQEFGPVPDTARYYKKMGVKWA
VIGDENYGEGSSREHAALEPRHLGGRVIITKSFARIHETNLKKQGLLPLTFADPADYNKI
HPVDKLSIVGLADFAPGKPLKCIIKHPNGSQETIMLNHTFNESQIEWFQAGSALNRMKEL
QQKSS
| Protein Alignment to Mouse |
sp|Q99KI0|ACON_MOUSE Aconitate hydratase, mitochondrial OS=Mus musculus
GN=Aco2 PE=1 SV=1
MGI:87880 Aco2 aconitase 2, mitochondrial (Chr 15)
Length = 780
Score = 3759 (1328.3 bits), Expect = 0., P = 0.
Identities = 706/782 (90%), Positives = 741/782 (94%)
Query: 1 MAPYCVLAARLRHALNGGIRRYHVASVLCQRAKVAMSHFEPNEYINYEKLEKNINIVRKR 60
MAPY +L RL+ AL G+R+YHVASVLCQRAKVAMSHFEP+EYI Y+ LEKNINIVRKR
Sbjct: 1 MAPYSLLVTRLQKAL--GVRQYHVASVLCQRAKVAMSHFEPSEYIRYDLLEKNINIVRKR 58
Query: 61 LDRPLTLSEKIVYGHLDDPAKQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKV 120
L+RPLTLSEKIVYGHLDDPA QEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKV
Sbjct: 59 LNRPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKV 118
Query: 121 AVPSTIHCDHLIEAQSGGEKDLRRAKDINQEVYNFLSTAGAKYGVGFWKPGSGIIHQIIL 180
AVPSTIHCDHLIEAQ GGEKDLRRAKDINQEVYNFL+TAGAKYGVGFW+PGSGIIHQIIL
Sbjct: 119 AVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIIL 178
Query: 181 ENYSYPGVMLIGTDSHTPNXXXXXXXXXXXXXADAVDVMAGIPWELKCPKVIGVKLTGKL 240
ENY+YPGV+LIGTDSHTPN ADAVDVMAGIPWELKCPKVIGVKLTG L
Sbjct: 179 ENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSL 238
Query: 241 SGWSSPKDVILKVAGILTVKGGTGAIIEYHGPGVDSISCTGMATICNMGAEIGATTSVFP 300
SGW+SPKDVILKVAGILTVKGGTGAI+EYHGPGVDSISCTGMATICNMGAEIGATTSVFP
Sbjct: 239 SGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFP 298
Query: 301 YNTRMKKYLGKTGRADIAALADEFQQYLVPDAGCQYDQVIEINLSELKPHINGPFTPDLA 360
YN RMKKYL KTGR DIA LA+EF+ +LVPD GCQYDQVIEINL+ELKPHINGPFTPDLA
Sbjct: 299 YNHRMKKYLSKTGRTDIANLAEEFKDHLVPDPGCQYDQVIEINLNELKPHINGPFTPDLA 358
Query: 361 HPVSDVGAVAEKEGWPVDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSKFTITP 420
HPV+DVG VAEKEGWP+DIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKS+FTITP
Sbjct: 359 HPVADVGTVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITP 418
Query: 421 GSEQIRATIERDGYAQILRDVGGLILANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTG 480
GSEQIRATIERDGYAQILRDVGG++LANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTG
Sbjct: 419 GSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTG 478
Query: 481 RNDANPETHAFVTSPEIVTALSIAGTLKFNPETDFLTGADGKKFKLEAPDADELPRLDFD 540
RNDANPETHAFVTSPEIVTAL+IAGTLKFNPETDFLTG DGKKFKLEAPDADELPR DFD
Sbjct: 479 RNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPDADELPRSDFD 538
Query: 541 PGQDTYQYPPKDGSGQHVDVSPTSQRLQLLEPFDKWDGKDLEDMLILIKVKGKCTTDHIS 600
PGQDTYQ+PPKD SGQ VDVSPTSQRLQLLEPFDKWDGKDLED+ ILIKVKGKCTTDHIS
Sbjct: 539 PGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHIS 598
Query: 601 AAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNALTQEFGPVPDTARYYKKMGVKWA 660
AAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNA+TQEFGPVPDTARYYKK G++W
Sbjct: 599 AAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWV 658
Query: 661 VIGDENYGEGSSREHAALEPRHLGGRVIITKSFARIHETNLKKQGLLPLTFADPADYNKI 720
VIGDENYGEGSSREHAALEPRHLGGR IITKSFARIHETNLKKQGLLPLTFADP+DYNKI
Sbjct: 659 VIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPSDYNKI 718
Query: 721 HPVDKLSIVGLADFAPGKPLKCIIKHPNGSQETIMLNHTFNESQIEWFQAGSALNRMKEL 780
HPVDKL+I GL DFAPGKPLKC+IKHPNG+QETI+LNHTFNE+QIEWF+AGSALNRMKEL
Sbjct: 719 HPVDKLTIQGLKDFAPGKPLKCVIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKEL 778
Query: 781 QQ 782
QQ
Sbjct: 779 QQ 780
| 