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Gene Model: Ogdh

NomenclatureGenomic Location
SymbolOgdhChromosome1
Name2-oxoglutarate dehydrogenase,
mitochondrial		Linkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates1: 85 Mbp

Molecular Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.

Molecular Function Terms:

binding
   cofactor binding
      coenzyme binding
         thiamine pyrophosphate binding
   protein binding
      chaperone binding
      heat shock protein binding
   vitamin binding
      thiamine pyrophosphate binding

catalytic activity
   oxidoreductase activity
      oxidoreductase activity, acting on the aldehyde or oxo group of donors
         oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
         oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Human Disease Association

No disease association.

Predicted Transcript
     1 ATGTTTCACTTAAGGACTTGTGCTACTAAATTGAGGCCACTAACGGCCTCACAGACTGTT
    61 AAGACAATATCTCAGAACAGGCCAGCAGCACCCAGGACGTTTCAGCAAATCAGGTGTTAC
   121 AGTGCACCTGTTGCTGCTGAGCCATTTTTGAGTGGGACTAATTCAAACTATGTGGAGGAA
   181 ATGTACTATGCTTGGTTGGAAAATCCTAAGAGTGTGCATAAGTCATGGGACATATTTTTC
   241 CGCAATGCCAATGCTGGAGCTGTTCCAGGAACTGCCTACCAAAGCCCCCCTCCATTGAGT
   301 ACCAGCCTATCCACACTAACACATGCACAATCTCTGGTTCAAGCACAGCCGAATGTAGAT
   361 AAACTGGTAGAAGATCATCTTGCAGTCCAATCTCTTATTAGAGCATATCAGATTCGAGGG
   421 CATCATGTAGCACAGCTCGACCCACTGGGCATCTTGGATGCTGATCTGGACTCTTCCGTT
   481 CCAGCTGATATTATCACTTCCACAGACAAACTGGGGTTTTATGGCCTGGATGAATCGGAT
   541 CTTGACAAGGTCTTTCACTTGCCCACTACCACCTTCATTGGAGGAAATGAGTCTGCTCTC
   601 CCACTTCGAGAAATCATCCGCCGTTTAGAGATGGCATACTGCCAACATATTGGTGTAGAA
   661 TTTATGTTCATTAATGATCTGGAGCAGTGTCAGTGGATCAGGCAGAAATTTGAAACTCCC
   721 GGAGTCATGCAGTTCTCTAATGAGGAAAAGCGCACTCTGCTGGCTAGATTGGTCCGGTCA
   781 ACCAGATTTGAAGAGTTCCTGCATAGAAAATGGTCTTCTGAAAAACGCTTCGGCTTGGAG
   841 GGCTGTGAGGTCCTGATCCCTGCTTTAAAGACAATAATTGACAAGTCAAGTGAAAAGGGA
   901 GTTGATTATGTGATCATGGGAATGCCTCATAGAGGCCGTCTGAATGTCCTTGCCAATGTT
   961 ATCAGAAAGGAATTGGAGCAGATTTTTTGCCAATTTGATTCCAAATTGGAGGCTGCAGAT
  1021 GAGGGCTCAGGTGATGTGAAGTATCATTTGGGAATGTATCACCGGAGAATTAATCGAGTT
  1081 ACTGACCGAACCATCACTCTTTCACTGGTTGCAAATCCTTCTCATTTGGAGGCTGCTGAT
  1141 CCAGTTGTTCAGGGCAAGACAAAGGCAGAGCAATTTTATTGTGGAGACACCGAAGGAAAA
  1201 AAGGTGATGTCTATCCTTTTGCATGGAGATGCTGCTTTTGCCGGGCAAGGTATAGTTTAT
  1261 GAGACTTTCCACTTGAGCGACCTGCCTTCCTATACGACACACGGGACCGTTCATGTAGTG
  1321 GTGAACAATCAGATTGGATTCACCACCGATCCCCGTATGGCTCGCTCTTCTCCATACCCA
  1381 ACAGACGTAGCCCGAGTGGTTAATGCACCCATCTTCCATGTTAATGCCGATGATCCAGAG
  1441 GCTGTGGTGTATGTGTGCAACGTGGCTGCTGAATGGCGCAGCACTTTCCACAAAGATGTA
  1501 GTTGTGGATCTGGTATGCTACAGGAGAAATGGGCACAATGAGATGGATGAGCCAATGTTC
  1561 ACCCAACCACTGATGTACAAACAAATTCGGAAGCAGAAGACTGTGCTGCAAAAATATGCT
  1621 GAGACACTAGTTTCACAAGGAGTGGTAAATCAACCTGAGTATGAGGAGGAAATTGCCAAG
  1681 TATGACAAGATCTGTGAGGAGGCCCATGCCAGGTCCAAGGACGAGAAAATCCTTCACATC
  1741 AAGCACTGGCTAGATTCTCCATGGCCTGGTTTCTTCACCCTGGATGGTCAGCCCAGGAGT
  1801 ATGACCTGCCCTTCTACTGGTTTGAATGAAGAGGATTTGGTCCATATAGGAAGGGTGGCA
  1861 AGCTCAGTTCCTGTTGAAAACTTCACAATCCATGGGGGTTTAAGCAGGATTCTAAAGACA
  1921 CGTGGAGAATTGGTTACTAATAGAACTGTAGATTGGGCCTTGGCAGAATACATGGCATTT
  1981 GGCTCTCTCCTTAAAGAGGGAATCCACATCCGACTGAGTGGACAAGATGTTGAGAGAGGA
  2041 ACATTCAGCCACCGACACCATGTCTTACACGACCAGAATGTTGACAAGAGAACCTGCATT
  2101 CCTATGAACCATCTGTGGCCAAATCAAGCTCCATATACAGTCTGCAATAGTTCACTTTCA
  2161 GAGTATGGAGTCCTGGGGTTTGAGCTAGGCTTTGCCATGGCAAGCCCCAATGCTTTGGTG
  2221 CTGTGGGAAGCTCAATTTGGTGACTTTCACAACACAGCTCAGTGTATTATTGACCAGTTC
  2281 ATCTGTTCTGGACAGTCCAAGTGGGTGAGACAAAATGGCATGGTACTCCTGCTTCCCCAT
  2341 GGCATGGAAGGAATGGGCCCTGAGCACTCTTCTGCCAGACCAGAGCGATTCCTGCAAATG
  2401 TGCAATGATGATCCAGATGTCTTCCCGAAACTAGATGATTTTGATGTCCGTCAGCTGTAT
  2461 GACTGCAATTGGATTGTAGTGAACTGTTCCACACCAGCAAACTTTTTCCATGTTGTGCGG
  2521 AGGCAGATACTTCTCCCCTTCCGGAAACCACTCATTGTCTTCACTCCAAAGTCATTGTTA
  2581 CGTCATCCTGAAGCTCGGTCCAGCTTTGATGACATGTTGACAGGTACACATTTCCAGCGT
  2641 ATTATTCCAGAAAATGGTGTTGCTGCGCAAAACCCAGAGGGGGTGAAGCGAATCCTCTTC
  2701 TGCACTGGCAAAGTGTACTATGAGCTCACTAGAGAGCGCAAAACCAGGGGTATGGAAGCA
  2761 GATGTGGCCATTACTAGGGTGGAGCAGTTATCCCCATTTCCCTTTGACCTCCTGTTAAAG
  2821 GAGTTCCATAAATACCCCAATGCGGACCTGGTTTGGTGTCAAGAGGAGCACAAAAACCAA
  2881 GGGTATTATGATTATGTAAAGCCTCGACTTCGCACAACCATTGACCGCGCAAAGCCAGTG
  2941 TGGTATGCTGGGCGTGAACCTGCTGCTGCACCAGCCACCGGCAACAAGAAGACTCACCTG
  3001 ACTGAACTGCAGCGCTTCCTGGACACTGCCTTCAACCTCGACTCTTTCAAGGGCTTGTCT
  3061 TAG

Predicted Protein Product
MFHLRTCATKLRPLTASQTVKTISQNRPAAPRTFQQIRCYSAPVAAEPFLSGTNSNYVEE
MYYAWLENPKSVHKSWDIFFRNANAGAVPGTAYQSPPPLSTSLSTLTHAQSLVQAQPNVD
KLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIITSTDKLGFYGLDESD
LDKVFHLPTTTFIGGNESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETP
GVMQFSNEEKRTLLARLVRSTRFEEFLHRKWSSEKRFGLEGCEVLIPALKTIIDKSSEKG
VDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINRV
TDRTITLSLVANPSHLEAADPVVQGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVY
ETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPE
AVVYVCNVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKTVLQKYA
ETLVSQGVVNQPEYEEEIAKYDKICEEAHARSKDEKILHIKHWLDSPWPGFFTLDGQPRS
MTCPSTGLNEEDLVHIGRVASSVPVENFTIHGGLSRILKTRGELVTNRTVDWALAEYMAF
GSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLS
EYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICSGQSKWVRQNGMVLLLPH
GMEGMGPEHSSARPERFLQMCNDDPDVFPKLDDFDVRQLYDCNWIVVNCSTPANFFHVVR
RQILLPFRKPLIVFTPKSLLRHPEARSSFDDMLTGTHFQRIIPENGVAAQNPEGVKRILF
CTGKVYYELTRERKTRGMEADVAITRVEQLSPFPFDLLLKEFHKYPNADLVWCQEEHKNQ
GYYDYVKPRLRTTIDRAKPVWYAGREPAAAPATGNKKTHLTELQRFLDTAFNLDSFKGLS
Protein Alignment to Mouse
sp|Q60597|ODO1_MOUSE 2-oxoglutarate dehydrogenase, mitochondrial OS=Mus
            musculus GN=Ogdh PE=1 SV=3
      MGI:1098267 Ogdh oxoglutarate dehydrogenase (lipoamide) (Chr 11)
        Length = 1023

 Score = 4915 (1735.2 bits), Expect = 0., P = 0.
 Identities = 922/1023 (90%), Positives = 955/1023 (93%)

Query:     1 MFHLRTCATKLRPLTASQTVKTISQNRPAAPRTFQQIRCYSAPVAAEPFLSGTNSNYVEE 60
             MFHLRTCA KLRPLTASQTVKT SQN+PAA RTFQQIRCYSAPVAAEPFLSGT+SNYVEE
Sbjct:     1 MFHLRTCAAKLRPLTASQTVKTFSQNKPAAIRTFQQIRCYSAPVAAEPFLSGTSSNYVEE 60

Query:    61 MYYAWLENPKSVHKSWDIFFRNANAGAVPGTAYQX-XXXXXXXXXXXXHAQSLVQAQPNV 119
             MY AWLENPKSVHKSWDIFFRN NAGA PGTAYQ              HAQSLV+AQPNV
Sbjct:    61 MYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLSLSRSSLATMAHAQSLVEAQPNV 120

Query:   120 DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIITSTDKLGFYGLDES 179
             DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADII+STDKLGFYGL ES
Sbjct:   121 DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLHES 180

Query:   180 DLDKVFHLPTTTFIGGNESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET 239
             DLDKVFHLPTTTFIGG E ALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET
Sbjct:   181 DLDKVFHLPTTTFIGGQEPALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET 240

Query:   240 PGVMQFSNEEKRTLLARLVRSTRFEEFLHRKWSSEKRFGLEGCEVLIPALKTIIDKSSEK 299
             PG+MQF+NEEKRTLLARLVRSTRFEEFL RKWSSEKRFGLEGCEVLIPALKTIID SS  
Sbjct:   241 PGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDMSSAN 300

Query:   300 GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR 359
             GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGD+KYHLGMYHRRINR
Sbjct:   301 GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDMKYHLGMYHRRINR 360

Query:   360 VTDRTITLSLVANPSHLEAADPVVQGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV 419
             VTDR ITLSLVANPSHLEAADPVV GKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV
Sbjct:   361 VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV 420

Query:   420 YETFHLSDLPSYXXXXXXXXXXNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDP 479
             YETFHLSDLPSY          NNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVN+DDP
Sbjct:   421 YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP 480

Query:   480 EAVVYVCNVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKTVLQKY 539
             EAV+YVC VAAEWR+TFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQK VLQKY
Sbjct:   481 EAVMYVCKVAAEWRNTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY 540

Query:   540 AETLVSQGVVNQPEYEEEIAKYDKICEEAHARSKDEKILHIKHWLDSPWPGFFTLDGQPR 599
             AE LVSQGVVNQPEYEEEI+KYDKICEEA  RSKDEKILHIKHWLDSPWPGFFTLDGQPR
Sbjct:   541 AELLVSQGVVNQPEYEEEISKYDKICEEAFTRSKDEKILHIKHWLDSPWPGFFTLDGQPR 600

Query:   600 SMTCPSTGLNEEDLVHIGRVASSVPVENFTIHGGLSRILKTRGELVTNRTVDWALAEYMA 659
             SMTCPSTGL E+ L HIG+VASSVPVENFTIHGGLSRILKTR ELVTNRTVDWALAEYMA
Sbjct:   601 SMTCPSTGLEEDVLFHIGKVASSVPVENFTIHGGLSRILKTRRELVTNRTVDWALAEYMA 660

Query:   660 FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL 719
             FGSLLKEGIH+RLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL
Sbjct:   661 FGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL 720

Query:   720 SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICSGQSKWVRQNGMVLLLP 779
             SEYGVLGFELGFAMASPNALVLWEAQFGDF+N AQCIIDQFIC GQ+KWVRQNG+VLLLP
Sbjct:   721 SEYGVLGFELGFAMASPNALVLWEAQFGDFNNMAQCIIDQFICPGQAKWVRQNGIVLLLP 780

Query:   780 HGMEGMGPEHSSARPERFLQMCNDDPDVFPKL--DDFDVRQLYDCNWIVVNCSTPANFFH 837
             HGMEGMGPEHSSARPERFLQMCNDDPDV P L  ++FD+ QLYDCNWIVVNCSTP NFFH
Sbjct:   781 HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLQEENFDINQLYDCNWIVVNCSTPGNFFH 840

Query:   838 VVRRQILLPFRKPLIVFTPKSLLRHPEARSSFDDMLTGTHFQRIIPENGVAAQNPEGVKR 897
             V+RRQILLPFRKPLIVFTPKSLLRHPEAR+SFD+ML GTHFQR+IPENG AAQ+P  VKR
Sbjct:   841 VLRRQILLPFRKPLIVFTPKSLLRHPEARTSFDEMLPGTHFQRVIPENGPAAQDPHKVKR 900

Query:   898 ILFCTGKVYYELTRERKTRGMEADVAITRVEQLSPFPFDLLLKEFHKYPNADLVWCQEEH 957
             +LFCTGKVYY+LTRERK R ME +VAITR+EQLSPFPFDLLLKE  KYPNA+L WCQEEH
Sbjct:   901 LLFCTGKVYYDLTRERKARNMEEEVAITRIEQLSPFPFDLLLKEAQKYPNAELAWCQEEH 960

Query:   958 KNQGYYDYVKPRLRTTIDRAKPVWYAGREPAAAPATGNKKTHLTELQRFLDTAFNLDSFK 1017
             KNQGYYDYVKPRLRTTIDRAKPVWYAGR+PAAAPATGNKKTHLTELQRFLDTAF+LD+FK
Sbjct:   961 KNQGYYDYVKPRLRTTIDRAKPVWYAGRDPAAAPATGNKKTHLTELQRFLDTAFDLDAFK 1020

Query:  1018 GLS 1020
               S
Sbjct:  1021 KFS 1023