| Nomenclature | Genomic Location |
| Symbol | F8 | Chromosome | X |
| Name | Coagulation factor VIII | Linkage map | unknown |
| Species | Dracomimus familiaris | Genome Coordinates | X: 54 Mbp |
| Molecular Function |
|
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
Molecular Function Terms:
binding
ion binding
cation binding
metal ion binding
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on L-amino acid peptides
endopeptidase activity
serine-type endopeptidase activity
serine hydrolase activity
serine-type peptidase activity
serine-type endopeptidase activity
|
| Human Disease Association |
|
Defects in F8 are the cause of hemophilia A (HEMA) [MIM:306700]. A disorder of blood coagulation
characterized by a permanent tendency to hemorrhage. About 50% of patients have severe hemophilia
resulting in frequent spontaneous bleeding into joints, muscles and internal organs. Less severe
forms are characterized by bleeding after trauma or surgery. Note=Of particular interest for the
understanding of the function of F8 is the category of CRM (cross-reacting material) positive patients
(approximately 5%) that have considerable amount of F8 in their plasma (at least 30% of normal), but
the protein is non-functional; i.e., the F8 activity is much less than the plasma protein level.
CRM-reduced is another category of patients in which the F8C antigen and activity are reduced to
approximately the same level. Most mutations are CRM negative, and probably affect the folding and
stability of the protein.
|
1 TTTTCTCTCTTTTCCCTGTCAGGCAAAAGCTGGTACACCCAGCCCAACACTACAGAGAAT
61 GCCTTTTCTGCAAACAGCGGGGCTCAGATGCACACTATCAATGGCTTCATGCATTCCCCC
121 CTACCTGAGCTCAAGGTGTGTCAGAAGAGGCCCATCTACTGGTATGTCATTGGCCTTGGA
181 ACCAGACCTGAAGTCCACTCCATTTTCTTCGAGGGACACTCTTTTCTTGTGAGAGACCAC
241 CGGCAGGCCACTCTGGACATCTCCCCAGCCACGTTTCTCACTGCCGAGACTACGCCCAGA
301 ACCAATGGCACGTTTCAGATGTTCTGCCAAATTCCATCCCATCAACAAGCTGGAATGGAA
361 ACCTTCATCAAGGTGGATGCCTGTCCAGACCCACCTGAGAAGAAGATGAGGATGGCAGAG
421 CCAAGTGAGGATGAAGATGAGTATGAGGACTATGATATGGAAACTGTGGTTATCAAGATG
481 GAAGATTTTACACCCAGGATTACCGGCCGTTCCCGTGCCAAGAGGCTGTCTGTGATGTGG
541 GAGCATTACATTGCAGCAGAAGAGGTAGACTGGGACTATGCCCCAGACAAGCGCTCCAAC
601 CAGGATAAACGCTTTCTCTTTTGTAGACAGTTTCTGGCACCTGGTCCCCAGCGGATTGGC
661 TCAAAGTACAAGAAAGTGAGATTTGTGGAATATGAGGATAGGACCTTCACGAGTCGGAAA
721 GCGTCAAACCCAGCTCATATGGGGATCCTGGGCCCGGTTCTTATAATTGGAGAAAAGAGA
781 AAGCTGATTATGTTTAAGAACCTCGCTGGACGGCCATACAACATATATCCCCATGGCATC
841 AGCAACGTCACCTCGTTTTTCCAGCTGAAAAAGGCCAAAAATCTCAATATGAAACTGTTG
901 CCTATTCGGCCTGGCCAGGTGTTTATATACAGGTGGAAAATAATGCCCGAGGACGGCCCA
961 ACCCGATCTGATCCCCGTTGCCTGACGCGCTACTATTCCAGCTCCGTCAAGCCGGCTAAG
1021 GATTTAGCATCTGGGCTAATCGGACCTTTACTCATTTGCCTGAAAGAGACCATGGACCAA
1081 AGAGGCAATCAGATTATGTCGGATGAAGCAAGGTTCGTGCTGTTTTCTGTCTTCGATGAA
1141 AACCGCAGCTGGTATTTGGCAGAGAATATCAACCGATCCTGTTCTGATGCCGCCAATGTC
1201 AACCCCCGTGATCCCAATTTCTATGCCTCCAATGTCATGCACAGCATCAACGGCTACATT
1261 TTCAATAACCTAGAGATACGGCTTTGCCGGAACGAAGTGGTGTATTGGTACATCCTCAGC
1321 GTCGGAGCCCAGACGGATGTCCTGTCCGTATTCTTCTCGGGAAATACCTTCAAGCACAAT
1381 ACAGTCTTTGAGGAGATCCTCACGCTTTTCCCTCTCTCCGGAGAGACTGTCTTCATGTCC
1441 ATGGAGAACCCAGGTATATGGACACTGGGATGCTTGAATCCTGACTTTAGAAAACGAGGA
1501 ATGAGTGCCAAATTGATTGTTTTCAAGTGCTCACAAGAAGTGGAGTCCGAGGAGGGAGAT
1561 TATGATTATGAGGAAACCATTCCAGAGGACTACATGATTCAAGCCAACATCCTACAACCA
1621 AGAGGTTTCCGCAAGAAGAAAGCCCCTTTCCAGCCTTACATAAAGACTGATGATAATAAT
1681 AATGCCAACTCTACTTTCAGTAATGAAATATTGAATAAAAATCAACATTCAGCTGTATAT
1741 CTTGGACAACCCAACCAGTTTACCAAATTAAACAGGAAAACCAACTCTACAGACCCATTA
1801 ACGCAACCTCAAGAAACGTTATATCTGGATGACATATCTTCATCTTCACCACAAGATCCA
1861 TCCTTCAACATGGTACCTAATAATGTTTTTTCAGCTGCAGAAGAATCAACCACACTGTCA
1921 ACCCCATCAACGCAAAGCTTCCAAGAACATTTGAGAAACTCATCTCTTGCTCATGAAGAG
1981 CCACACCATAATGAGAGTTTATTTGAGACCACAACTCATCTGGATCATGAAAAACTTGGC
2041 TTAGAAATGCCCAGAGAAAGAGAAAGAGCCGGGATGCTACAAGAATTGGTACATTGGGAG
2101 AAAGGAGAGGATAAAAGGCCACCTTCATCTCATCCAGTGGAAAAGGTGGAGATATTTCAT
2161 GAAAGTCCTGTTACCACAAATCAATCCAAAGAGGCGTTTGGTAATGCAGTATTTGCCGAA
2221 AATCAGACTCTGAAGGCAATAATTGATGGTAGCCTTTCAAAACTAAATAAAAGAGGTCCA
2281 GGTTCCATCACACTTGAAAGAACTCCAGTGGAAGGTGCATTGATGGCAAATACAGTGTCG
2341 AATGGGGAAGGAGTATTGAATGACAGCAATTCCTTCAACATGACCAGTGCATCTGCATCA
2401 TTAAATGATTTGGAAAATGAGCCGGTTTTTCAAGATATATCACTGGAAATTCAAAACACT
2461 GGTCCGCCAAGAGCAACAACAAGCCCCGCAGTTAAAGAGGTATTATTGCAGAACTATGAC
2521 GCTGTCTCCCAAGATCCAAACAATGATTCATCTTATAAAGCAAGCGGCCAAGAGAGCAAA
2581 ACACTAGCAATCAGAGAATCATTACAGTCAGTATCACATACTTCCAAAATTATGGAAAAT
2641 GAGAGCACCTCAACATCTACAAGTGGAGATCTAAAGGTTGGGAAAGAGAAGATGACGCAA
2701 CTGAGAATGGACAGAACGACTGAAAGCCCAGATGTTTTGAATGAACACAACTCCTTCTTT
2761 GCACAGAATGGCAAGACAATAGATTCAGATAGATTGACTAGCTCCTTAAGCATTATAGAC
2821 AATGCTATATCTACTAATGACAAGCTGGATAGTAATGATAGAACACATGCCTTTTACTAT
2881 TATGAAGGAACAGATAATTTAACACACCAAGACATTTCCCAAGATGTTAACCAAGGCAAC
2941 AATCAATCTGGAAGGGAGAACGAAGCCATCCTCAGTAGGAGTCAACCCAAGAGTATCCTA
3001 CATTCCTTAGAACCCCTAAATACACTTACAGAGAAAAATGTTACACAACTGAGGCCAACA
3061 GATGCCAAATTAAAGGTTTCTGAAGAAAAAGAAGATGTTCTTCACCAAGGTCATACATTT
3121 TCGTTACAATCAGTTGACTTGGGACATGGCACCGTTTCTGAAGAGCCTGAAAGGAAAGGA
3181 GAGAGCCAGGTACGATCGCAACTAGACTTTCAGAGTCATGAAAAATCAAAAGAAACAAGT
3241 ACATCAATGATAAATGAAACAAAAAGTTCTAGTGAAGCTGAAGGACAAGCTTTGCTCAGT
3301 GTTAATATGAAGAAGGGAAACAGTGAGGCTTCTATACCAAAGGCAAATATCATAGTTGAG
3361 GCAGCAGAAGGGAATCAAAAAGCTTCTCCTGGCAGGACAACAGTTGCATCTCCTCCACCA
3421 AACTCAGTCAGATACGTCTCAGACTCACATTCCATGAACATCTCTGTTTCTCAATCAAAA
3481 ATAACAGAGACAATCACTCAAGATGGAAGCAAACAAAACTCAAAAGTCGGACGCTTCATT
3541 CAACTGGAGGATGCCAAAAGTACTAATGCGATTCCTGAGTCTAGGGGAACAATAACTTTG
3601 AGAGACTATTATATAAAAAACAAACCAGGACGGAGCCCCACTGTCGTTGCAGGAAGAGAG
3661 CACACAGATGTCACTTCGACCCCCCAGAAGACCACTGAGCAGACCAATGAGGTTGGACTT
3721 ACTGAAGCAAAGGAATCCCCAGCGATGCAGTGTGTTGATCTAGAAACTCCTTTGGAATCA
3781 CATCTGAGAGATTCTGGTGTAGATTATGAGCAAACATTAAGGAACGAGTCTTTGTTTGGT
3841 GCCACAAAAAGGGAGGAGCTTGGGATTTCAACCAAAAGGGCCTCAGCAGACAATGATGTG
3901 CTTGCTCAAGAGGACTCGACCATCAACCAGAACCTCCAAGATGAACCAACGGATGAAGTC
3961 AAGGAATTTGGTGGTGAAGGAGGCAATATTCCTCCCCTCAGGAGTAAACAGGGGGGAGGA
4021 ACAGAGGCCGACATTCAGACACCCAGGAAAGGTGAAAGCACAGAAATGATCAATTCCATA
4081 TCACCTTCTGGCTTCAGCAGACCAGTCAAGACAAACTTCTCAAAGAATCTGAAAGGGCCA
4141 TCTGACTATGACGACTACAGTAACACAGAAGAGACCTTGGAGGAATTTGACATTTATGGA
4201 GAAGATGAGCATGATCCACGGACTATGACAGGGAAAGTACGGCAATATTACATTGCAGCG
4261 GTTGAAGTGATGTGGGATTATGGAAGTCATCTTCCTTCACCGTATCTCCCAGACCAGGAT
4321 TTGAAGAACAAGCCATCCACGAAGTATAAGAAAGTTGTCTACAGAGGGTACCTTGATCGG
4381 ACCTTTACTCAGCCATATGTCTGCGGAGAGTTGGATGAACATTTGGGCATCTTGGGGCCA
4441 TATATCCGGGGACAGGTTGGAGATGTCATCATGGTGACATTTAAGAACATGGCTTCTCGC
4501 CCGTACTCCTTCCATTCCAACTTGCTGCCCTACGAGGGAACGATGGAAGAGCGGCGGCAG
4561 CCGTGGAGGGAGGAAGTGCAGCCAGGCGAGATCAGGGAGTATTCCTTCACGGTCTTGCAG
4621 CAAATGGCTCCTACGACCCATGAGTTTGACTGCAAAGCGTGGGCATACTTCTCCAGTGTG
4681 GATCTGGAGAAAGACCTACACTCCGGTCTCATTGGGCCCCTGGTGATCTGCCACCCTGGT
4741 GTGCTGAGCTCGACCCACCTTCGGCAACTGTCTATCCAGGAATTCACTCTGCTGTTCATG
4801 GTCTTTGATGAGACAAAAAGCTGGTATTATGTTGAGAACCTCGAGAGAACCTGCTTGCCC
4861 TTCTGTGGAGTCAGTACAGATGATCTTGTCTTGAAAACAAACCATTCATTCTATGCTATC
4921 AATGGCTATGTGAGAGACACGTTGCCAGGGCTTGTGATGGGTCAACACCAGAGGGTCAGG
4981 TGGTACCTGCTGAATGCAGGTGATGCTGAGGATATCCATTCTGTCCACTTCCACGGACAA
5041 GTCTTCACCATCAGAAAGGACCAAGAGTACCGCATGGGGGTCTACAACCTCTATTCTGGA
5101 ACGTTTGAAACGGTGGAAATGCAGCCATCCCATCCTGGGATTTGGCGCGTGGAGTGTGCC
5161 GTTGGGGAGCATGAGCAGGCTGGAATGAGCGCCCTGTTCTTAGTGTATGACAAGCGGTGT
5221 CAAACGCCTTTGGGCCTGGCTTCTGGGTACATTGCAGACTCTCAGATTACAGCGTCAAGT
5281 CACCATGGTGAATGGGTCCCGAGTTTATCCAGGTTGCACAAATCGGGGTCAATCAATGCC
5341 TGGAGTACGGACCAGGAGAAAGCTTGGATTCAGGTGGATCTGCTGCATCCAAAGATCATC
5401 CATGGAATCAAGACGCAAGGAGCACGTCAAAAGTTCTCCAAGCTCTACATTTCCCAGTTT
5461 GTCATCTTCTACAGCCTGGATGGCGAGAGGTGGAAGGCTTATAAAGGCAATGCCACCAGC
5521 TCTGAGATGTTATTCTTTGGAAACGTGGGTGCGACTGGTGTGAAAGACAATTCCTTCGAC
5581 CCTCCGATTGTCGCGCGCTATATCCGCCTTCGCCCGAACTACTTCAACATCCGCAACACG
5641 TTACGCATGGAGCTCATCGGCTGTGACCTGAACAGTTGCTCCATGCCGCTGGGAATGGAA
5701 AGCAAAACCATCTCCGATGAACAGATCTCAGCCTCTTCCTACATTGACAGTGTCTTCACC
5761 ACTTGGTCCCCCTTTCAAGCCAGGCTTCACTTGGAGGGCAGAACCAATGCTTGGAGACCA
5821 AAGGTGGATGGCATGGCCGAATGGCTCCAGGTGAACTTTCTGAAGACCATGCGGTTGACA
5881 GGGCTGGTGACCCAAGGAGCAAAGGCCGTCTTCACCCACATGTTTGTGCAGGAATTTTCT
5941 CTCTCAAGCAGCCAGGACGGCACACATTGGAGTCCTGTTTTGCGAGATGGAAAAGAGAAG
6001 ATTTTCCAGGGAAATCAAGATCATGTCAGCCCAGTGGTAAATTTCCTGGATTCTCCCATT
6061 TTTGCGCAGTATTTGAGGATACACCCACGCCGCTGGAATAAACACATTGCGCTGCGGATA
6121 GAGATTTTGGGCTGCGACACCCAGCAAATGATCTAG
| Predicted Protein Product |
FSLFSLSGKSWYTQPNTTENAFSANSGAQMHTINGFMHSPLPELKVCQKRPIYWYVIGLG
TRPEVHSIFFEGHSFLVRDHRQATLDISPATFLTAETTPRTNGTFQMFCQIPSHQQAGME
TFIKVDACPDPPEKKMRMAEPSEDEDEYEDYDMETVVIKMEDFTPRITGRSRAKRLSVMW
EHYIAAEEVDWDYAPDKRSNQDKRFLFCRQFLAPGPQRIGSKYKKVRFVEYEDRTFTSRK
ASNPAHMGILGPVLIIGEKRKLIMFKNLAGRPYNIYPHGISNVTSFFQLKKAKNLNMKLL
PIRPGQVFIYRWKIMPEDGPTRSDPRCLTRYYSSSVKPAKDLASGLIGPLLICLKETMDQ
RGNQIMSDEARFVLFSVFDENRSWYLAENINRSCSDAANVNPRDPNFYASNVMHSINGYI
FNNLEIRLCRNEVVYWYILSVGAQTDVLSVFFSGNTFKHNTVFEEILTLFPLSGETVFMS
MENPGIWTLGCLNPDFRKRGMSAKLIVFKCSQEVESEEGDYDYEETIPEDYMIQANILQP
RGFRKKKAPFQPYIKTDDNNNANSTFSNEILNKNQHSAVYLGQPNQFTKLNRKTNSTDPL
TQPQETLYLDDISSSSPQDPSFNMVPNNVFSAAEESTTLSTPSTQSFQEHLRNSSLAHEE
PHHNESLFETTTHLDHEKLGLEMPRERERAGMLQELVHWEKGEDKRPPSSHPVEKVEIFH
ESPVTTNQSKEAFGNAVFAENQTLKAIIDGSLSKLNKRGPGSITLERTPVEGALMANTVS
NGEGVLNDSNSFNMTSASASLNDLENEPVFQDISLEIQNTGPPRATTSPAVKEVLLQNYD
AVSQDPNNDSSYKASGQESKTLAIRESLQSVSHTSKIMENESTSTSTSGDLKVGKEKMTQ
LRMDRTTESPDVLNEHNSFFAQNGKTIDSDRLTSSLSIIDNAISTNDKLDSNDRTHAFYY
YEGTDNLTHQDISQDVNQGNNQSGRENEAILSRSQPKSILHSLEPLNTLTEKNVTQLRPT
DAKLKVSEEKEDVLHQGHTFSLQSVDLGHGTVSEEPERKGESQVRSQLDFQSHEKSKETS
TSMINETKSSSEAEGQALLSVNMKKGNSEASIPKANIIVEAAEGNQKASPGRTTVASPPP
NSVRYVSDSHSMNISVSQSKITETITQDGSKQNSKVGRFIQLEDAKSTNAIPESRGTITL
RDYYIKNKPGRSPTVVAGREHTDVTSTPQKTTEQTNEVGLTEAKESPAMQCVDLETPLES
HLRDSGVDYEQTLRNESLFGATKREELGISTKRASADNDVLAQEDSTINQNLQDEPTDEV
KEFGGEGGNIPPLRSKQGGGTEADIQTPRKGESTEMINSISPSGFSRPVKTNFSKNLKGP
SDYDDYSNTEETLEEFDIYGEDEHDPRTMTGKVRQYYIAAVEVMWDYGSHLPSPYLPDQD
LKNKPSTKYKKVVYRGYLDRTFTQPYVCGELDEHLGILGPYIRGQVGDVIMVTFKNMASR
PYSFHSNLLPYEGTMEERRQPWREEVQPGEIREYSFTVLQQMAPTTHEFDCKAWAYFSSV
DLEKDLHSGLIGPLVICHPGVLSSTHLRQLSIQEFTLLFMVFDETKSWYYVENLERTCLP
FCGVSTDDLVLKTNHSFYAINGYVRDTLPGLVMGQHQRVRWYLLNAGDAEDIHSVHFHGQ
VFTIRKDQEYRMGVYNLYSGTFETVEMQPSHPGIWRVECAVGEHEQAGMSALFLVYDKRC
QTPLGLASGYIADSQITASSHHGEWVPSLSRLHKSGSINAWSTDQEKAWIQVDLLHPKII
HGIKTQGARQKFSKLYISQFVIFYSLDGERWKAYKGNATSSEMLFFGNVGATGVKDNSFD
PPIVARYIRLRPNYFNIRNTLRMELIGCDLNSCSMPLGMESKTISDEQISASSYIDSVFT
TWSPFQARLHLEGRTNAWRPKVDGMAEWLQVNFLKTMRLTGLVTQGAKAVFTHMFVQEFS
LSSSQDGTHWSPVLRDGKEKIFQGNQDHVSPVVNFLDSPIFAQYLRIHPRRWNKHIALRI
EILGCDTQQMI
| Protein Alignment to Mouse |
sp|Q06194|FA8_MOUSE Coagulation factor VIII OS=Mus musculus GN=F8 PE=2 SV=2
MGI:88383 F8 coagulation factor VIII (Chr X)
Length = 2319
Score = 2248 (796.4 bits), Expect = 0., Sum P(3) = 0.
Identities = 419/676 (61%), Positives = 527/676 (77%)
Query: 1381 SDYDDYSNTEETLEEFDIYGED-EHDPRTMTGKVRQYYIAAVEVMWDYG---SH-LPSPY 1435
+DYDD + T ET+E+FDIY ED + PR+ K R Y+IAAVE +WDYG SH L + Y
Sbjct: 1652 TDYDD-AITIETIEDFDIYSEDIKQGPRSFQQKTRHYFIAAVERLWDYGMSTSHVLRNRY 1710
Query: 1436 LPDQDLKNKPSTKYKKVVYRGYLDRTFTQPYVCGELDEHLGILGPYIRGQVGDVIMVTFK 1495
D N P ++KKVV++ + D +F+QP GEL+EHLG+LGPYIR +V D IMVTFK
Sbjct: 1711 QSD----NVP--QFKKVVFQEFTDGSFSQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFK 1764
Query: 1496 NMASRPYSFHSNLLPYEGTMEERR--QPWREEVQPGEIREYSFTVLQQMAPTTHEFDCKA 1553
N ASRPYSF+S+L+ Y+ E++R +P R V+P E + Y + V MAPT EFDCKA
Sbjct: 1765 NQASRPYSFYSSLISYK---EDQRGEEPRRNFVKPNETKIYFWKVQHHMAPTEDEFDCKA 1821
Query: 1554 WAYFSSVDLEKDLHSGLIGPLVICHPGVLSSTHLRQLSIQEFTLLFMVFDETKSWYYVEN 1613
WAYFS VDLE+D+HSGLIGPL+ICH L+ H RQ+S+QEF LLF +FDETKSWY+ EN
Sbjct: 1822 WAYFSDVDLERDMHSGLIGPLLICHANTLNPAHGRQVSVQEFALLFTIFDETKSWYFTEN 1881
Query: 1614 LERTCLPFCGVSTDDLVLKTNHSFYAINGYVRDTLPGLVMGQHQRVRWYLLNAGDAEDIH 1673
++R C C +D LK N+ F+AINGYV DTLPGLVM Q QR+RWYLL+ G+ E+I
Sbjct: 1882 VKRNCKTPCNFQMEDPTLKENYRFHAINGYVMDTLPGLVMAQDQRIRWYLLSMGNNENIQ 1941
Query: 1674 SVHFHGQVFTIRKDQEYRMGVYNLYSGTFETVEMQPSHPGIWRVECAVGEHEQAGMSALF 1733
S+HF G VFT+RK +EY+M VYNLY G FET+EM PS GIWRVEC +GEH QAGMS LF
Sbjct: 1942 SIHFSGHVFTVRKKEEYKMAVYNLYPGVFETLEMIPSRAGIWRVECLIGEHLQAGMSTLF 2001
Query: 1734 LVYDKRCQTPLGLASGYIADSQITASSHHGEWVPSLSRLHKSGSINAWSTDQEKAWIQVD 1793
LVY K+CQ PLG+ASG I D QITAS H+G+W P+L+RLH SGSINAWST + +WI+VD
Sbjct: 2002 LVYSKQCQIPLGMASGSIRDFQITASGHYGQWAPNLARLHYSGSINAWSTKEPFSWIKVD 2061
Query: 1794 LLHPKIIHGIKTQGARQKFSKLYISQFVIFYSLDGERWKAYKGNATSSEMLFFGNVGATG 1853
LL P I+HGIKTQGARQKFS LYISQF+I YSLDG++W +Y+GN+T + M+FFGNV ++G
Sbjct: 2062 LLAPMIVHGIKTQGARQKFSSLYISQFIIMYSLDGKKWLSYQGNSTGTLMVFFGNVDSSG 2121
Query: 1854 VKDNSFDPPIVARYIRLRPNYFNIRNTLRMELIGCDLNSCSMPLGMESKTISDEQISASS 1913
+K NSF+PPI+ARYIRL P + +IR+TLRMEL+GCDLNSCS+PLGMESK ISD QI+ASS
Sbjct: 2122 IKHNSFNPPIIARYIRLHPTHSSIRSTLRMELMGCDLNSCSIPLGMESKVISDTQITASS 2181
Query: 1914 YIDSVFTTWSPFQARLHLEGRTNAWRPKVDGMAEWLQVNFLKTMRLTGLVTQGAKAVFTH 1973
Y ++F TWSP QARLHL+GRTNAWRP+V+ +WLQV+ KTM++TG++TQG K++FT
Sbjct: 2182 YFTNMFATWSPSQARLHLQGRTNAWRPQVNDPKQWLQVDLQKTMKVTGIITQGVKSLFTS 2241
Query: 1974 MFVQEFSLSSSQDGTHWSPVLRDGKEKIFQGNQDHVSPVVNFLDSPIFAQYLRIHPRRWN 2033
MFV+EF +SSSQDG HW+ +L +GK K+FQGNQD +P++N LD P+ +YLRIHP+ W
Sbjct: 2242 MFVKEFLISSSQDGHHWTQILYNGKVKVFQGNQDSSTPMMNSLDPPLLTRYLRIHPQIWE 2301
Query: 2034 KHIALRIEILGCDTQQ 2049
IALR+EILGC+ QQ
Sbjct: 2302 HQIALRLEILGCEAQQ 2317
Score = 1459 (518.7 bits), Expect = 0., Sum P(3) = 0.
Identities = 315/702 (44%), Positives = 428/702 (60%)
Query: 1 FSLFSLSGKSWYTQPNT--TEN--AFSANSGAQMHTINGFMHSPLPELKVCQKRPIYWYV 56
F++F GKSW+++ N T++ + SA +MHT+NG+++ LP L C ++ +YW+V
Sbjct: 219 FAVFD-EGKSWHSETNDSYTQSMDSASARDWPKMHTVNGYVNRSLPGLIGCHRKSVYWHV 277
Query: 57 IGLGTRPEVHSIFFEGHSFLVRDHRQATLDISPATFLTAETTPRTNGTFQMFCQIPSHQQ 116
IG+GT PE+HSIF EGH+F VR+HRQA+L+ISP TFLTA+T G F +FC I SH+
Sbjct: 278 IGMGTTPEIHSIFLEGHTFFVRNHRQASLEISPITFLTAQTLLIDLGQFLLFCHISSHKH 337
Query: 117 AGMETFIKVDACPDPPE-KKMRMAEPSXXXXXXXXXXMETVVIKMEDFTPRITGRSRAKR 175
GME ++KVD+CP+ + +K E M+ + D +P I RS AK+
Sbjct: 338 DGMEAYVKVDSCPEESQWQKKNNNEEMEDYDDDLYSEMDMFTLDY-DSSPFIQIRSVAKK 396
Query: 176 LSVMWEHYIAAEEVDWDYAPDKRSNQDKRFLFCRQFLAPGPQRIGSKYKKVRFVEYEDRT 235
W HYI+AEE DWDYAP ++ + + Q+L+ GP RIG KYKKVRF+ Y D T
Sbjct: 397 YPKTWIHYISAEEEDWDYAPSVPTSDNGSYK--SQYLSNGPHRIGRKYKKVRFIAYTDET 454
Query: 236 FTSRKASNPAHMGILGPVLI--IGEKRKLIMFKNLAGRPYNIYPHGISNVTSFF-QXXXX 292
F +R+ G+LGP+L +G+ LI+FKN A RPYNIYPHGI++V+ +
Sbjct: 455 FKTRETIQH-ESGLLGPLLYGEVGDTL-LIIFKNQASRPYNIYPHGITDVSPLHARRLPR 512
Query: 293 XXXXXXXXPIRPGQVFIYRWKIMPEDGPTRSDPRCLTRYYSSSVKPAKDLASGLIGPLLI 352
PI PG++F Y+W + EDGPT+SDPRCLTRYYSS + P +DLASGLIGPLLI
Sbjct: 513 GIKHVKDLPIHPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFINPERDLASGLIGPLLI 572
Query: 353 CLKETMDQRGNQIMSDEARFVLFSVFDENRSWYLAENINRSCSDAANVNPRDPNFYASNV 412
C KE++DQRGNQ+MSD+ +LFS+FDEN+SWY+ EN+ R +AA P+DP F ASN+
Sbjct: 573 CYKESVDQRGNQMMSDKRNVILFSIFDENQSWYITENMQRFLPNAAKTQPQDPGFQASNI 632
Query: 413 MHSINGYIFNNLEIRLCRNEVVYWYILSVGAQTDVLSVFFSGNTFKHNTVFEEILTLFPL 472
MHSINGY+F++LE+ +C +EV YW+ILSVGAQTD LS+FFSG TFKH V+E+ LTLFP
Sbjct: 633 MHSINGYVFDSLELTVCLHEVAYWHILSVGAQTDFLSIFFSGYTFKHKMVYEDTLTLFPF 692
Query: 473 SGETVFMSMENPGIWTLGCLNPDFRKRGMSAKLIVFKCSQEVESEEGDYDYEETIPEDYM 532
SGETVFMSMENPG+W LGC N DFRKRGM+A L V C + S+ + YE+ IP +
Sbjct: 693 SGETVFMSMENPGLWVLGCHNSDFRKRGMTALLKVSSCDKST-SDYYEEIYED-IPTQLV 750
Query: 533 IQANILQPRGFRKKKAPFQPYIKTDDNNNANSTFSNEILNKNQHSAVYLGQPNQFTKLNR 592
+ N++ PR F FQ T+ N F + + KN + +P QF ++
Sbjct: 751 NENNVIDPRSF------FQ---NTNHPNTRKKKFKDSTIPKNDMEKI---EP-QFEEIAE 797
Query: 593 --KTNS---TDPLT---QPQET---LYLXXXXXXXXXXXXFNMVPNNVFSAAEESTTLST 641
K S +D L Q T L+L + PN + S S
Sbjct: 798 MLKVQSVSVSDMLMLLGQSHPTPHGLFLSDGQEAIYEAIHDDHSPNAIDSNEGPSKVTQL 857
Query: 642 PSTQSFQEHLRNSSLAHEEPHHNESLFETTTHLDHEKLGLEM 683
E + + + N+SL ETT + +KLGL++
Sbjct: 858 RPESHHSEKIVFTPQPGLQLRSNKSL-ETTIEVKWKKLGLQV 898
Score = 454 (164.9 bits), Expect = 4.0e-72, Sum P(3) = 4.0e-72
Identities = 122/387 (31%), Positives = 191/387 (49%)
Query: 1366 SRPVKTNFSK--NLKGPSDYDDYSNTEETLEEFDIYGEDEHDPRTMTGKVRQ---YYIAA 1420
S P ++ + K N + DYDD +E + D R++ K + +YI+A
Sbjct: 348 SCPEESQWQKKNNNEEMEDYDDDLYSEMDMFTLDYDSSPFIQIRSVAKKYPKTWIHYISA 407
Query: 1421 VEVMWDYGSHLPSP---YLPDQDLKNKP---STKYKKVVYRGYLDRTFTQPYVCGELDEH 1474
E WDY +P+ Q L N P KYKKV + Y D TF +
Sbjct: 408 EEEDWDYAPSVPTSDNGSYKSQYLSNGPHRIGRKYKKVRFIAYTDETFKTRET---IQHE 464
Query: 1475 LGILGPYIRGQVGDVIMVTFKNMASRPYSFHSNLLPYEGTMEERRQPWREE------VQP 1528
G+LGP + G+VGD +++ FKN ASRPY+ + + + + RR P + + P
Sbjct: 465 SGLLGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVSPLHARRLPRGIKHVKDLPIHP 524
Query: 1529 GEIREYSFTVLQQMAPTTHEFDCKAWAYFSSVDLEKDLHSGLIGPLVICHPGVLSSTHLR 1588
GEI +Y +TV + PT + C Y S ++ E+DL SGLIGPL+IC+ + +
Sbjct: 525 GEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFINPERDLASGLIGPLLICYKESVDQRGNQ 584
Query: 1589 QLSIQEFTLLFMVFDETKSWYYVENLERTCLPFCGVSTDDLVLKTNHSFYAINGYVRDTL 1648
+S + +LF +FDE +SWY EN++R D + ++ ++INGYV D+L
Sbjct: 585 MMSDKRNVILFSIFDENQSWYITENMQRFLPNAAKTQPQDPGFQASNIMHSINGYVFDSL 644
Query: 1649 PGLVMGQHQRVRWYLLNAGDAEDIHSVHFHGQVFTIRKDQEYRMGVYNLYSGTFETVEMQ 1708
L + H+ W++L+ G D S+ F G F + E + ++ +SG ETV M
Sbjct: 645 E-LTVCLHEVAYWHILSVGAQTDFLSIFFSGYTFKHKMVYEDTLTLFP-FSG--ETVFMS 700
Query: 1709 PSHPGIWRVECAVGEHEQAGMSALFLV 1735
+PG+W + C + + GM+AL V
Sbjct: 701 MENPGLWVLGCHNSDFRKRGMTALLKV 727
Score = 418 (152.2 bits), Expect = 4.4e-33, Sum P(2) = 4.4e-33
Identities = 112/337 (33%), Positives = 167/337 (49%)
Query: 1413 VRQYYIAAVEVMWDYGS-------HLPSPYLP--DQDLKNKPSTKYKKVVYRGYLDRTFT 1463
+R+YY+ AVE+ W+Y H S +LP S YKK V+ Y D+ F
Sbjct: 21 IRRYYLGAVELSWNYIQSDLLSVLHTDSRFLPRMSTSFPFNTSIMYKKTVFVEYKDQLFN 80
Query: 1464 QPYVCGELDEHLGILGPYIRGQVGDVIMVTFKNMASRPYSFHSNLLPY----EGT-MEER 1518
+ +G+LGP I +V D +++T KNMAS P S H+ + Y EG E++
Sbjct: 81 ---IAKPRPPWMGLLGPTIWTEVHDTVVITLKNMASHPVSLHAVGVSYWKASEGDEYEDQ 137
Query: 1519 RQPWREE---VQPGEIREYSFTVLQQMAPTTHEFDCKAWAYFSSVDLEKDLHSGLIGPLV 1575
+E V PGE Y + VL++ P + C ++Y S VDL KDL+SGLIG L+
Sbjct: 138 TSQMEKEDDKVFPGESHTYVWQVLKENGPMASDPPCLTYSYMSHVDLVKDLNSGLIGALL 197
Query: 1576 ICHPGVLSSTHLRQLSIQEFTLLFMVFDETKSWYYVENLERTCLPFCGVSTDDLVLKTNH 1635
+C G LS + L +F LLF VFDE KSW+ N T S D +
Sbjct: 198 VCKEGSLSKERTQML--YQFVLLFAVFDEGKSWHSETNDSYT------QSMDSASARDWP 249
Query: 1636 SFYAINGYVRDTLPGLVMGQHQR-VRWYLLNAGDAEDIHSVHFHGQVFTIRKDQEYRMGV 1694
+ +NGYV +LPGL+ G H++ V W+++ G +IHS+ G F +R ++ + +
Sbjct: 250 KMHTVNGYVNRSLPGLI-GCHRKSVYWHVIGMGTTPEIHSIFLEGHTFFVRNHRQASLEI 308
Query: 1695 YNLYSGTFETVEMQPSHPGIWRVECAVGEHEQAGMSA 1731
+ TF T + G + + C + H+ GM A
Sbjct: 309 SPI---TFLTAQTLLIDLGQFLLFCHISSHKHDGMEA 342
Score = 414 (150.8 bits), Expect = 1.6e-34, P = 1.6e-34
Identities = 112/362 (30%), Positives = 172/362 (47%)
Query: 182 HY-IAAEEVDWDYAPDKRSNQDKRFLFCRQFLAPGPQRIGSKYKKVRFVEYEDRTFTSR- 239
HY IAA E WDY R+ PQ +KKV F E+ D +F+
Sbjct: 1686 HYFIAAVERLWDYGMSTSHVLRNRYQSDNV-----PQ-----FKKVVFQEFTDGSFSQPL 1735
Query: 240 -KASNPAHMGILGPVLIIG-EKRKLIMFKNLAGRPYNIYPHGISNVTSFFQXXXXXXXXX 297
+ H+G+LGP + E ++ FKN A RPY+ Y S++ S+ +
Sbjct: 1736 YRGELNEHLGLLGPYIRAEVEDNIMVTFKNQASRPYSFY----SSLISYKEDQRGEEPRR 1791
Query: 298 XXXPIRPGQVFIYRWKIMPEDGPTRSDPRCLTRYYSSSVKPAKDLASGLIGPLLICLKET 357
++P + IY WK+ PT + C Y S V +D+ SGLIGPLLIC T
Sbjct: 1792 NF--VKPNETKIYFWKVQHHMAPTEDEFDCKAWAYFSDVDLERDMHSGLIGPLLICHANT 1849
Query: 358 MDQ-RGNQIMSDEARFVLFSVFDENRSWYLAENINRSCSDAANVNPRDPNFYASNVMHSI 416
++ G Q+ E +LF++FDE +SWY EN+ R+C N DP + H+I
Sbjct: 1850 LNPAHGRQVSVQEFA-LLFTIFDETKSWYFTENVKRNCKTPCNFQMEDPTLKENYRFHAI 1908
Query: 417 NGYIFNNLE-IRLCRNEVVYWYILSVGAQTDVLSVFFSGNTF---KHNTVFEEILTLFPL 472
NGY+ + L + + +++ + WY+LS+G ++ S+ FSG+ F K + L+P
Sbjct: 1909 NGYVMDTLPGLVMAQDQRIRWYLLSMGNNENIQSIHFSGHVFTVRKKEEYKMAVYNLYPG 1968
Query: 473 SGETVFMSMENPGIWTLGCLNPDFRKRGMSAKLIVF--KCSQEVESEEGDY-DYEETIPE 529
ET+ M GIW + CL + + GMS +V+ +C + G D++ T
Sbjct: 1969 VFETLEMIPSRAGIWRVECLIGEHLQAGMSTLFLVYSKQCQIPLGMASGSIRDFQITASG 2028
Query: 530 DY 531
Y
Sbjct: 2029 HY 2030
Score = 393 (143.4 bits), Expect = 6.5e-278, Sum P(3) = 6.5e-278
Identities = 116/369 (31%), Positives = 185/369 (50%)
Query: 177 SVMWEHYIAAEEVDWDYAP-DKRS--NQDKRFLFCRQFLAPGPQRIGSKYKKVRFVEYED 233
S + +Y+ A E+ W+Y D S + D RFL + P YKK FVEY+D
Sbjct: 19 SAIRRYYLGAVELSWNYIQSDLLSVLHTDSRFL--PRMSTSFPFNTSIMYKKTVFVEYKD 76
Query: 234 RTFTSRKASNPAHMGILGPVLIIG-EKRKLIMFKNLAGRPYNIYPHGIS--NVTSFFQXX 290
+ F K P MG+LGP + +I KN+A P +++ G+S + +
Sbjct: 77 QLFNIAKP-RPPWMGLLGPTIWTEVHDTVVITLKNMASHPVSLHAVGVSYWKASEGDEYE 135
Query: 291 XXXXXXXXXXP-IRPGQVFIYRWKIMPEDGPTRSDPRCLTRYYSSSVKPAKDLASGLIGP 349
+ PG+ Y W+++ E+GP SDP CLT Y S V KDL SGLIG
Sbjct: 136 DQTSQMEKEDDKVFPGESHTYVWQVLKENGPMASDPPCLTYSYMSHVDLVKDLNSGLIGA 195
Query: 350 LLICLKETMDQRGNQIMSDEARFVL-FSVFDENRSWYLAENINRSCS-DAANVNPRD-PN 406
LL+C + ++ + Q++ +FVL F+VFDE +SW+ N + + S D+A+ RD P
Sbjct: 196 LLVCKEGSLSKERTQMLY---QFVLLFAVFDEGKSWHSETNDSYTQSMDSASA--RDWPK 250
Query: 407 FYASNVMHSINGYIFNNLEIRL-CRNEVVYWYILSVGAQTDVLSVFFSGNTF---KHNTV 462
MH++NGY+ +L + C + VYW+++ +G ++ S+F G+TF H
Sbjct: 251 ------MHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEIHSIFLEGHTFFVRNHRQA 304
Query: 463 FEEILTLFPLSGETVFMSMENPGIWTLGCLNPDFRKRGMSAKLIVFKCSQEVESEEGDYD 522
EI + L+ +T+ + + G + L C + GM A + V C +E + ++ + +
Sbjct: 305 SLEISPITFLTAQTLLIDL---GQFLLFCHISSHKHDGMEAYVKVDSCPEESQWQKKNNN 361
Query: 523 YEETIPEDY 531
EE EDY
Sbjct: 362 -EEM--EDY 367
Score = 185 (70.2 bits), Expect = 4.1e-10, P = 4.1e-10
Identities = 45/138 (32%), Positives = 66/138 (47%)
Query: 1 FSLFSLSGKSWYTQPNTTENA-----F-----SANSGAQMHTINGFMHSPLPELKVCQKR 50
F++F + KSWY N N F + + H ING++ LP L + Q +
Sbjct: 1867 FTIFDET-KSWYFTENVKRNCKTPCNFQMEDPTLKENYRFHAINGYVMDTLPGLVMAQDQ 1925
Query: 51 PIYWYVIGLGTRPEVHSIFFEGHSFLVR---DHRQATLDISPATFLTAETTPRTNGTFQM 107
I WY++ +G + SI F GH F VR +++ A ++ P F T E P G +++
Sbjct: 1926 RIRWYLLSMGNNENIQSIHFSGHVFTVRKKEEYKMAVYNLYPGVFETLEMIPSRAGIWRV 1985
Query: 108 FCQIPSHQQAGMETFIKV 125
C I H QAGM T V
Sbjct: 1986 ECLIGEHLQAGMSTLFLV 2003
Score = 65 (27.9 bits), Expect = 0., Sum P(3) = 0.
Identities = 116/590 (19%), Positives = 225/590 (38%)
Query: 728 QSKEAFGNAVFAENQTLKAIIDG-SLSKLNKRGPGSITLERTPVEGAL-MANTVSNGEGV 785
+ K G A+ ++ TL D SL K NK S T E+ E + N+ ++ +
Sbjct: 995 REKRFHGIALLTKDNTL--FKDNVSLMKTNKTYNHSTTNEKLHTESPTSIENSTTDLQDA 1052
Query: 786 LNDSNSFNMTSASASLNDLENEPVFQDISLEIQNTGPPRATTSPAVKEVL-LQNYDAVSQ 844
+ NS + +A ++D + S ++ TTS K++ ++ D + Q
Sbjct: 1053 ILKVNS-EIQEVTALIHD---GTLLGKNSTYLRLNHMLNRTTSTKNKDIFHRKDEDPIPQ 1108
Query: 845 DPNNDSSYKASGQESKTLAIRESLQSVSHTSKIMENESTSTSTSGDLKVGKEKMTQLRMD 904
D N SK L + ES S + + + S + + + +++ L
Sbjct: 1109 DEENTIM-----PFSKMLFLSES-------SNWFKKTNGNNSLNSEQEHSPKQLVYLMFK 1156
Query: 905 RTTESPDVLNEHNSFFAQNGKTIDSDRLTSSLSIIDNAISTNDK--LDSNDRTHAFYYYE 962
+ ++ L+E N T++ D T ++ + D A N L + H +
Sbjct: 1157 KYVKNQSFLSEKNKV------TVEQDGFTKNIGLKDMAFPHNMSIFLTTLSNVHENGRHN 1210
Query: 963 GTDNLTHQDISQDVNQGNNQSGRENEAILSRSQPKSILHSLEPLN-TLTEKNVTQLRPTD 1021
N+ + + + + + +EA S++ K IL N +L E +V L+
Sbjct: 1211 QEKNIQEEIEKEALIEEKVVLPQVHEATGSKNFLKDILILGTRQNISLYEVHVPVLQNIT 1270
Query: 1022 AKLKVSEEKEDV-LHQGHTFSLQS--VDLGHGTVSEEPERKGESQVRSQLDFQSHEKSK- 1077
+ ++ V +H H F + G V++ E + + Q +++
Sbjct: 1271 S---INNSTNTVQIHMEHFFKRRKDKETNSEGLVNKTREMVKNYPSQKNITTQRSKRALG 1327
Query: 1078 --ETSTSMINETKSSSEAEGQAL-LSVNMKKGNSEASIPKANIIVEAAEGNQKASPGRTT 1134
ST + S++ + + S MKK +++S+ +++I + N S T
Sbjct: 1328 QFRLSTQWLKTINCSTQCIIKQIDHSKEMKKFITKSSLSDSSVIKSTTQTNSSDSHIVKT 1387
Query: 1135 VASPPPNSVRYVSDSHSMNISVSQSKITETITQDGSKQNSKVGRFIQLEDAKSTNAIPES 1194
A PP + R + ++ S S I + T+ Q S F L++ K N P S
Sbjct: 1388 SAFPPIDLKRSPFQNKFSHVQAS-SYIYDFKTKSSRIQESN--NF--LKETKINN--P-S 1439
Query: 1195 RGTITLRDYYIKNK---PGRSPT-VVAGREHTDVTSTPQKTTEQTNEVGLTEAKESPAMQ 1250
+ + + K PG+S T V ++ ++ E++ ++ L +
Sbjct: 1440 LAILPWNMFIDQGKFTSPGKSNTNSVTYKKRENIIFLKPTLPEESGKIELLPQVSIQEEE 1499
Query: 1251 CVDLETPLES--HLRDSGVDYEQTLRNESLFGATKREELGISTKRASADN 1298
+ ET S HL + Q ++ + + KR I K S+ N
Sbjct: 1500 ILPTETSHGSPGHLNLMKEVFLQKIQGPTKWNKAKRHGESIKGKTESSKN 1549
Score = 54 (24.1 bits), Expect = 9.5e-277, Sum P(3) = 9.5e-277
Identities = 49/242 (20%), Positives = 93/242 (38%)
Query: 908 ESPD--VLNEHNSFFAQNGKTIDSDRLTSSLSIIDNAISTNDKLDSNDRTHAFYYYEGTD 965
E+P VL HNS F + G +T+ L + ST+D + +
Sbjct: 702 ENPGLWVLGCHNSDFRKRG-------MTALLKVSSCDKSTSDYYEEIYEDIPTQLVNENN 754
Query: 966 NLTHQDISQDVNQGNNQSGRENEAILSRSQPKSILHSLEP-LNTLTEK-NVTQLRPTDAK 1023
+ + Q+ N N + + ++ + PK+ + +EP + E V + +D
Sbjct: 755 VIDPRSFFQNTNHPNTRKKKFKDSTI----PKNDMEKIEPQFEEIAEMLKVQSVSVSDML 810
Query: 1024 LKVSEEKED----VLHQGHTFSLQSVDLGHGTVSEEPERKGESQVRSQLDFQSHEKSKET 1079
+ + + L G +++ H + + +G S+V +QL +SH K
Sbjct: 811 MLLGQSHPTPHGLFLSDGQEAIYEAIHDDHSPNAID-SNEGPSKV-TQLRPESHHSEKIV 868
Query: 1080 STSMIN-ETKSSSEAEGQALLSVNMKK-GNSEASIPKANIIVEAAEGNQKASPGRTTVAS 1137
T + +S+ E + V KK G +S+P + N KA+ +T +
Sbjct: 869 FTPQPGLQLRSNKSLE--TTIEVKWKKLGLQVSSLPSNLMTTTILSDNLKATFEKTDSSG 926
Query: 1138 PP 1139
P
Sbjct: 927 FP 928
Score = 46 (21.3 bits), Expect = 2.7e-238, Sum P(3) = 2.7e-238
Identities = 40/182 (21%), Positives = 74/182 (40%)
Query: 404 DPNFYASNVMHSINGYIFNNL----EIRLCRNEVVYWYILSVGAQT---DVLSVFFSGNT 456
D N S +M+S +N+ RL R + + L T D +S+ + T
Sbjct: 965 DSNILDSTLMYSQESLPRDNILSMENDRLLREKRFHGIALLTKDNTLFKDNVSLMKTNKT 1024
Query: 457 FKHNTVFEEILTLFPLSGETVFMSME------NPGIWTLGCLNPDFRKRGMSAKLIVFK- 509
+ H+T E++ T P S E ++ N I + L D G ++ +
Sbjct: 1025 YNHSTTNEKLHTESPTSIENSTTDLQDAILKVNSEIQEVTALIHDGTLLGKNSTYLRLNH 1084
Query: 510 -CSQEVESEEGDYDY---EETIPEDYMIQANILQPRG---FRKKKAPFQPYIKTDDNNNA 562
++ ++ D + E+ IP+D + N + P F + + + + KT+ NN+
Sbjct: 1085 MLNRTTSTKNKDIFHRKDEDPIPQD---EENTIMPFSKMLFLSESSNW--FKKTNGNNSL 1139
Query: 563 NS 564
NS
Sbjct: 1140 NS 1141
Score = 44 (20.5 bits), Expect = 4.0e-72, Sum P(3) = 4.0e-72
Identities = 11/25 (44%), Positives = 15/25 (60%)
Query: 1994 LRDGKEKIFQGNQDHVSPVVNFLDS 2018
L DG+E I++ D SP N +DS
Sbjct: 825 LSDGQEAIYEAIHDDHSP--NAIDS 847
Score = 41 (19.5 bits), Expect = 2.2e-275, Sum P(3) = 2.2e-275
Identities = 16/64 (25%), Positives = 27/64 (42%)
Query: 520 DYDYEETIPEDYMIQANILQPRGFRKKKAPFQPYIKTDDNNNANSTFSNEILNKNQHSAV 579
DY Y IP+D M ++ P K+ + + N++S +NE N Q
Sbjct: 1561 DYHYAAQIPKD-MWKSKEKSPEIISIKQE--DTILSLRPHGNSHSIGANEKQNWPQRETT 1617
Query: 580 YLGQ 583
++ Q
Sbjct: 1618 WVKQ 1621
Score = 40 (19.1 bits), Expect = 5.2e-30, Sum P(2) = 5.2e-30
Identities = 7/18 (38%), Positives = 11/18 (61%)
Query: 552 PYIKTDDNNNANSTFSNE 569
PYI+ + +N TF N+
Sbjct: 1749 PYIRAEVEDNIMVTFKNQ 1766
Score = 39 (18.8 bits), Expect = 0., Sum P(3) = 0.
Identities = 13/47 (27%), Positives = 22/47 (46%)
Query: 710 SHPVEKVEIFHESPVTTNQSKEAFGNAVFAEN---QTLKAII-DGSL 752
+H ++ ESP + S +A+ N Q + A+I DG+L
Sbjct: 1026 NHSTTNEKLHTESPTSIENSTTDLQDAILKVNSEIQEVTALIHDGTL 1072
Score = 38 (18.4 bits), Expect = 1.6e-277, Sum P(4) = 1.6e-277
Identities = 7/22 (31%), Positives = 11/22 (50%)
Query: 576 HSAVYLGQPNQFTKLNRKTNST 597
H LG+ + + +LN N T
Sbjct: 1068 HDGTLLGKNSTYLRLNHMLNRT 1089
Score = 37 (18.1 bits), Expect = 0., Sum P(3) = 0.
Identities = 13/39 (33%), Positives = 20/39 (51%)
Query: 663 HNESLFETTTHLDHE--KLGLE--MPRERERAGMLQELV 697
HN S+F TT HE + E + E E+ +++E V
Sbjct: 1191 HNMSIFLTTLSNVHENGRHNQEKNIQEEIEKEALIEEKV 1229
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