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Gene Model: F10

NomenclatureGenomic Location
SymbolF10Chromosome1
NameCoagulation factor XLinkage mapunknown
SpeciesDracomimus familiarisGenome Coordinates1: 29 Mbp

Molecular Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Molecular Function Terms:

binding
   ion binding
      cation binding
         metal ion binding
   lipid binding
      phospholipid binding

catalytic activity
   hydrolase activity
      peptidase activity
         peptidase activity, acting on L-amino acid peptides
            endopeptidase activity
               serine-type endopeptidase activity
   serine hydrolase activity
      serine-type peptidase activity
         serine-type endopeptidase activity

Human Disease Association

Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.

Predicted Transcript
     1 CTAGATGGTAACCAGTGTAACTCAAACCCTTGCCATTATGGAGGGTCATGCAAAGATGGC
    61 ATAAATAGCTACACCTGCACATGCTTGGCTGGTTATGATGGACAAAACTGCGAACACATC
   121 ACACATAAATCCTGCAAAGTGGATAATGGAGAGTGTTGGCAGTTCTGTAAAAATGTAGAA
   181 AATACTGTGGAATGCTCTTGCACGGATGGGTATATCCTGGACAACGATGGACAATCCTGT
   241 GTTGCTACAGCTAATTATCCATGTGGTAAAATCAAAAGGACAAAGACGAAGGCAAAAAGA
   301 GAAGCAAGCTTCTTCAACCACAACCCCAGCACTTATGACTATGATGCAATTCCTGAAGAC
   361 ATTTATTACGATGGTATGCAGAATTGCAGTAATGTGGTTCCCCATCTACCGTCCCAGGAG
   421 GGAACTGCACTCAATGAGAACGATGTCAACTCTGACCTTAACCTGCGAATTGTTAATGGG
   481 TCCAATTGTGAATTGGGTCAATGTCCCTGGCAGGCACTTCTGCTAGATGAAAAAGAAGAA
   541 GGGTTTTGTGGAGGAACAGTACTGAGCCGTATCCATGTGCTTACTGCCGCTCATTGTATA
   601 AATCAAACAAAAACAATTAAAGTTGTTGTAGGGGAGGTGGATACTAACACAAGAACAACG
   661 GGAACTCTTCACACTGTGGAGAAAGTATATGTGCATCAGAAATTTGTGTTGGCAACCTAT
   721 GACTATGATATCGCCATAATTCAATTGAGGAACCCAATTCAGTTTTCTGAATACGTGATC
   781 CCTGCGTGCCTTCCCACAGCTGACTTTGCCAATCAGGTCCTCATGAGACAACCAACTGGT
   841 ATTGTCAGTGGTTTTGGGCGTCTCCATGAAAGAGGCCGGAAAGCCTCCAAGCTTCAAGTC
   901 ATTAGAGTGCCGTACATCGAGAGGCATACCTGCAAGCTGTCAAGTAATTTTGTAATCACT
   961 GAAAATATGTTCTGTGCTGGCTATCGCACTCTGGCTCAAGATGCATGTCAGGGAGACAGT
  1021 GGAGGCCCTCATGTAACTGAATACAAGGGCACTCACTTTGTTACGGGTGTGATCAGCTGG
  1081 GGAGAAGGGTGTGCAAGGGAGGATAAGTATGGCATTTATACAAAGGTGTCCAAATTCATA
  1141 GGCTGGGTGAGGAGAATAATCCGTCAGAGACGACAGCCAGCCAGCAGTCCTGCTGGCACA
  1201 ACAGGGGGCATGGTCCCTTTTGTAAAAAAAAATAAAAGG

Predicted Protein Product
LDGNQCNSNPCHYGGSCKDGINSYTCTCLAGYDGQNCEHITHKSCKVDNGECWQFCKNVE
NTVECSCTDGYILDNDGQSCVATANYPCGKIKRTKTKAKREASFFNHNPSTYDYDAIPED
IYYDGMQNCSNVVPHLPSQEGTALNENDVNSDLNLRIVNGSNCELGQCPWQALLLDEKEE
GFCGGTVLSRIHVLTAAHCINQTKTIKVVVGEVDTNTRTTGTLHTVEKVYVHQKFVLATY
DYDIAIIQLRNPIQFSEYVIPACLPTADFANQVLMRQPTGIVSGFGRLHERGRKASKLQV
IRVPYIERHTCKLSSNFVITENMFCAGYRTLAQDACQGDSGGPHVTEYKGTHFVTGVISW
GEGCAREDKYGIYTKVSKFIGWVRRIIRQRRQPASSPAGTTGGMVPFVKKNKR
Protein Alignment to Mouse
sp|O88947|FA10_MOUSE Coagulation factor X OS=Mus musculus GN=F10 PE=1 SV=1
      MGI:103107 F10 coagulation factor X (Chr 8)
        Length = 481

 Score = 1099 (391.9 bits), Expect = 5.2e-112, P = 5.2e-112
 Identities = 202/403 (50%), Positives = 275/403 (68%)

Query:     2 DGNQCNSNPCHYGGSCKDGINSYTCTCLAGYDGQNCEHITHKSCKVDNGECWQFCKNVEN 61
             DG+QC S+PC   G+C+DGI  YTCTC  G++G+NCE    K C++DNG+C QFC+  +N
Sbjct:    86 DGDQCESSPCQNQGACRDGIGGYTCTCSEGFEGKNCELFVRKLCRLDNGDCDQFCREEQN 145

Query:    62 TVECSCTDGYILDNDGQSCVATANYPCGKIKRTKTKAKREASFFNHNPSTYDY-DAIPED 120
             +V CSC  GY L NDG+SC++TA +PCGKI  T  + KR  +  N + S  D  DA+ ++
Sbjct:   146 SVVCSCASGYFLGNDGKSCISTAPFPCGKI--TTGRRKRSVAL-NTSDSELDLEDALLDE 202

Query:   121 IYYDGMQNCSNVVPHLPSQEGTALNENDVNSDLNLRIVNGSNCELGQCPWQALLLDEKEE 180
                D +    N +  L   E      +D   DL +RIV G  C+ G+CPWQALL++E  E
Sbjct:   203 ---DFLSPTENPIELLNLNETQPERSSD---DL-VRIVGGRECKDGECPWQALLINEDNE 255

Query:   181 GFCGGTVLSRIHVLTAAHCINQTKTIKVVVGEVDTNTRTTGTL-HTVEKVYVHQKFVLAT 239
             GFCGGT+L+  ++LTAAHC++Q +  KV VG+ +T       + H V+ V  H KF   T
Sbjct:   256 GFCGGTILNEFYILTAAHCLHQARRFKVRVGDRNTEKEEGNEMVHEVDVVIKHNKFQRDT 315

Query:   240 YDYDIAIIQLRNPIQFSEYVIPACLPTADFANQVLMRQPTGIVSGFGRLHERGRKASKLQ 299
             YDYDIA+++L+ PI F   V PACLP  D+A   LM Q TGIVSGFGR HE+GR+++ L+
Sbjct:   316 YDYDIAVLRLKTPITFRMNVAPACLPQKDWAESTLMTQKTGIVSGFGRTHEKGRQSNILK 375

Query:   300 VIRVPYIERHTCKLSSNFVITENMFCAGYRTLAQDACQGDSGGPHVTEYKGTHFVTGVIS 359
             ++ VPY++R+TCKLS++F IT+NMFCAGY    +DACQGDSGGPHVT +K T++VTG++S
Sbjct:   376 MLEVPYVDRNTCKLSTSFSITQNMFCAGYEAKLEDACQGDSGGPHVTRFKNTYYVTGIVS 435

Query:   360 WGEGCAREDKYGIYTKVSKFIGWVRRIIRQRRQPASSPAGTTG 402
             WGEGCAR+ KYGIYTKV+ F+ W+ R ++ R  P +    T G
Sbjct:   436 WGEGCARKGKYGIYTKVTTFLKWIDRSMKARVGPTAETPRTAG 478