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Gene Model: Col2a1

NomenclatureGenomic Location
SymbolCol2a1ChromosomeX
NameCollagen alpha-1(II) chainLinkage mapunknown
SpeciesDracomimus familiarisGenome CoordinatesX: 56 Mbp

Molecular Function

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

Molecular Function Terms:

binding
   protein binding
      growth factor binding
         platelet-derived growth factor binding

structural molecule activity
   extracellular matrix structural constituent

Human Disease Association

Defects in COL2A1 are the cause of spondyloepiphyseal dysplasia congenital type (SEDC) [MIM:183900]. This disorder is characterized by disproportionate short stature and pleiotropic involvement of the skeletal and ocular systems.

Defects in COL2A1 are the cause of spondyloepimetaphyseal dysplasia Strudwick type (SEMD-STR) [MIM:184250]. A bone disease characterized by disproportionate short stature from birth, with a very short trunk and shortened limbs, and skeletal abnormalities including lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses. A distinctive radiographic feature is irregular sclerotic changes, described as dappled in the metaphyses of the long bones.

Defects in COL2A1 are the cause of achondrogenesis type 2 (ACG2) [MIM:200610]; also known as achondrogenesis-hypochondrogenesis type II. ACG2 is a disease characterized by the absence of ossification in the vertebral column, sacrum and pubic bones.

Defects in COL2A1 are the cause of Legg-Calve-Perthes disease (LCPD) [MIM:150600]; also known as Legg-Perthes disease or Perthes disease. LCPD is characterized by loss of circulation to the femoral head, resulting in avascular necrosis in a growing child. Clinical pictures of the disease vary, depending on the phase of disease progression through ischemia, revascularization, fracture and collapse, and repair and remodeling of the bone.

Defects in COL2A1 are the cause of Kniest dysplasia (KD) [MIM:156550]; also known as Kniest syndrome or metatropic dwarfism type II. KD is a moderately severe chondrodysplasia phenotype that results from mutations in the COL2A1 gene. Characteristics of the disorder include a short trunk and extremities, mid-face hypoplasia, cleft palate, myopia, retinal detachment, and hearing loss.

Defects in COL2A1 are a cause of primary avascular necrosis of femoral head (ANFH) [MIM:608805]; also known as ischemic necrosis of the femoral head or osteonecrosis of the femoral head. ANFH causes disability that often requires surgical intervention. Most cases are sporadic, but families in which there is an autosomal dominant inheritance of the disease have been identified. It has been estimated that 300,000 to 600,000 people in the United States have ANFH. Approximately 15,000 new cases of this common and disabling disorder are reported annually. The age at the onset is earlier than that for osteoarthritis. The diagnosis is typically made when patients are between the ages of 30 and 60 years. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy in leg length, cause considerable disability. Moreover, nearly 10 percent of the 500,000 total-hip arthroplasties performed each year in the United States involve patients with ANFH. As a result, this disease creates a substantial socioeconomic cost as well as a burden for patients and their families.

Defects in COL2A1 are the cause of osteoarthritis with mild chondrodysplasia (OACD) [MIM:604864]. Osteoarthritis is a common disease that produces joint pain and stiffness together with radiologic evidence of progressive degeneration of joint cartilage. Some forms of osteoarthritis are secondary to events such as trauma, infections, metabolic disorders, or congenital or heritable conditions that deform the epiphyses or related structures. In most patients, however, there is no readily identifiable cause of osteoarthritis. Inheritance in a Mendelian dominant manner has been demonstrated in some families with primary generalized osteoarthritis. Reports demonstrate coinheritance of primary generalized osteoarthritis with specific alleles of the gene COL2A1, the precursor of the major protein of cartilage.

Defects in COL2A1 are the cause of platyspondylic lethal skeletal dysplasia Torrance type (PLSD-T) [MIM:151210]. Platyspondylic lethal skeletal dysplasias (PLSDs) are a heterogeneous group of chondrodysplasias characterized by severe platyspondyly and limb shortening. PLSD-T is characterized by varying platyspondyly, short ribs with anterior cupping, hypoplasia of the lower ilia with broad ischial and pubic bones, and shortening of the tubular bones with splayed and cupped metaphyses. Histology of the growth plate typically shows focal hypercellularity with slightly enlarged chondrocytes in the resting cartilage and relatively well-preserved columnar formation and ossification at the chondro-osseous junction. PLSD-T is generally a perinatally lethal disease, but a few long-term survivors have been reported.

Defects in COL2A1 are the cause of multiple epiphyseal dysplasia with myopia and conductive deafness (EDMMD) [MIM:132450]. Multiple epiphyseal dysplasia is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDMMD is an autosomal dominant disorder characterized by epiphyseal dysplasia associated with progressive myopia, retinal thinning, crenated cataracts, conductive deafness.

Defects in COL2A1 are the cause of spondyloperipheral dysplasia (SPD) [MIM:271700]. SPD patients manifest short stature, midface hypoplasia, sensorineural hearing loss, spondyloepiphyseal dysplasia, platyspondyly and brachydactyly.

Defects in COL2A1 are the cause of Stickler syndrome type 1 (STL1) [MIM:108300]; also known as vitreous type 1, or membranous vitreous type. STL1 is an autosomal dominant form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence, bone disorders and sensorineural deafness. Ocular disorders may include juvenile cataract, myopia, strabismus, vitreoretinal or chorioretinal degeneration, retinal detachment, and chronic uveitis. Robin sequence includes an opening in the roof of the mouth (a cleft palate), a large tongue (macroglossia), and a small lower jaw (micrognathia). Bones are affected by slight platyspondylisis and large, often defective epiphyses. Juvenile joint laxity is followed by early signs of arthrosis. The degree of hearing loss varies among affected individuals and may become more severe over time. Syndrome expressivity is variable.

Defects in COL2A1 are the cause of Stickler syndrome type 1 non-syndromic ocular (STL1O) [MIM:609508]. STL1O is an autosomal dominant form of Stickler syndrome characterized by the ocular signs typically seen in STL1 such as cataract, myopia, retinal detachment. STL1 systemic features of premature osteoarthritis, cleft palate, hearing impairment, and craniofacial abnormalities are either absent or very mild in STL1O patients.

Defects in COL2A1 are a cause of rhegmatogenous retinal detachment autosomal dominant (DRRD) [MIM:609508]. Rhegmatogenous retinal detachment most frequently results from a break or tear in the retina that allows fluid from the vitreous humor to enter the potential space beneath the retina. It is often associated with pathologic myopia and in most cases leads to visual impairment or blindness if untreated.

Predicted Transcript
     1 GAGGAGGCAGGCAACTGTGTGCAGGATGGGCAGAGGTATAGTGATAAAGATGTATGGAAA
    61 CCCGAACCCTGCCGGATTTGTGTCTGTGATACTGGGACGGTCCTCTGCGATGACATACTC
   121 TGCGAAGAAATGAGAGATTGTCCCAACCCCGAGATCCCCTTCGGAGAATGTTGCCCCATC
   181 TGTCCAACTGACCAGCCTACCACCAGTGGTCGGCAACCTGGACCCAAGGGACAAAAAGGA
   241 GAACCTGGCGATATTAAAGATGTTGTAGGACCAAGAGGCCCCCTTGGACCACAGGGACCT
   301 TCCGGTGAACAAGGACCAAGAGGAGAACGTGGTGATAAAGGAGAAAAAAAGGGTACCCCT
   361 GGCCCCCGTGGCAGAGATGGCGAACCTGGTACACCTGGCAACCCTGGCCCTCCTGGACCC
   421 CCAGGCCCTCCAGGCCCCCCTGGTCTTGGCGGAAACTTTGGTGCTCAGATGGCTGGAGGA
   481 TTTGATGAGAAAGCAGGAGGTGCTCAGATGGGAGTGATGCAAGGACCTATGGGACCTATG
   541 GGACCACGAGGGCCCCCAGGACCACCAGGATCTCCTGGCCCTCAAGGATTTCAAGGCAGC
   601 CCTGGAGAACCCGGAGAATCTGGCACTAGTGGTCCAATGGGTCCCGGCCCACCTGGACCT
   661 CCTGGAAAACCTGGTGATGACGGTGAAGCTGGCAAACCTGGCAAATCTGGAGAACGTGGA
   721 CTACCTGGGCCTCAGGGCGCTCGAGGTTTTCCTGGGACCCCAGGTCTTCCTGGTGTAAAG
   781 GGACACAGAGGTTTCCCTGGATTAGATGGTTCCAAGGGAGAAGCTGGTGCTCCAGGTGCT
   841 AAGGGTGAATCTGGGTCTGCGGGTGAGAATGGTTCTCCTGGCCCCATGGGTCCCCGTGGT
   901 CTCCCAGGTGAGAGAGGACGTCCTGGCTCTTCTGGTGCTGCTGGTGCTCGTGGTAATGAT
   961 GGCCTTCCTGGTCCAGCTGGTCCACCCGGACCCGTTGGTCCTGCTGGATCCCCAGGCTTC
  1021 CCAGGTGCACCAGGTGCAAAGGGTGAAGCTGGCCCTACTGGCGCTCGTGGACCTGAGGGT
  1081 GCCCAAGGTTCCCGAGGTGAACCTGGAAACCCTGGCTCTCCTGGCCCGTCAGGAGCTTCA
  1141 GGCAACCCTGGAAATGATGGAATCCCTGGTGCCAAAGGATCTGCGGGTGCTCCTGGCATT
  1201 GCTGGCGCTCCTGGTTTCCCTGGTCCCCGTGGACCACCTGGGCCTCAGGGGGCAACTGGG
  1261 CCTTTGGGTCCCAAAGGTCAGACGGGAGAACCTGGAATTGCAGGCTTCAAAGGTGAACAA
  1321 GGCCCCAAGGGTGAACATGGCCCTGCTGGCCCACAAGGGCCTCCTGGACCAGCTGGTGAG
  1381 GAAGGCAAGAGAGGTGGCCGTGGTGAACCAGGATCTGCAGGGCCCATTGGACCACCTGGC
  1441 GAGAGGGGTGCTCCCGGAAATCGTGGTTTCCCAGGACAAGATGGATTAGCTGGTCCCAAG
  1501 GGTGCTCCTGGTGAACGTGGACCTCCTGGCCTTGGAGGTCCCAAAGGTGCTAGTGGAGAT
  1561 CCTGGCCGTCCTGGAGAGCCTGGCCTTCCTGGTGCTAGGGGTCTCACTGGTCGTCCCGGT
  1621 GATGCTGGTCCTCAAGGCAAACTTGGTCCATCTGGTGCTCCTGGTGAAGATGGACGGCCT
  1681 GGTCCCCCTGGTCCACAAGGTGCCCGTGGTCAGCCTGGTGTCATGGGCTTCCCAGGACCT
  1741 AAAGGTGCTAATGGTGAAGCTGGTAAAGCTGGTGAAAAGGGACTTCCTGGTGCTCCTGGA
  1801 CTAAGGGGTCTTCCTGGTAAAGATGGCGAGACAGGAGCTGGTGGACCCCCAGGACCTTCT
  1861 GGCCCAGCTGGTGAGAGAGGTGAACAAGGTGCTCCAGGACCTTCTGGATTCCAGGGTCTT
  1921 CCAGGGCCCCCAGGTCCTCCAGGTGAAAATGGCAAATCAGGTGACCAGGGTGTTCCTGGT
  1981 GAGGCTGGTGCTCCTGGTCTTGTTGGTCCCAGAGGTGAACGTGGTTTCCCAGGTGAACGT
  2041 GGGTCTGCAGGTGCCCAAGGTTTGCAAGGACCTCGTGGGCTTCCTGGCACTCCTGGTACT
  2101 GATGGGCCCAAGGGTGCAACTGGTCCTCCTGGTGCCCTTGGAGCACAAGGGCCTCCCGGT
  2161 CTGCAGGGAATGCCTGGCGAGAGAGGAGCTGCAGGTATCGGTGGACCAAAAGGAGACAGG
  2221 GGTGATGTTGGTGAGAAGGGCCCAGAAGGTGCACCTGGCAAAGATGGAAACAGAGGTTTG
  2281 ACTGGTCCCATTGGTCCCCCTGGCCCAGCTGGTGGCAACGGAGAGAAGGGTGAAGCTGGT
  2341 CCTCCTGGCCCATCTGGTGCAGCCGGTGCTCGTGGGGCCCCTGGTGACCGTGGTGAACCT
  2401 GGTGCTCCTGGTCCTGCTGGATTTGCTGGCCCCCCTGGTGCTGATGGCCAACCTGGTGCT
  2461 AAAGGCGAGCAAGGTGAATCTGGACAGAAAGGAGATGCTGGATCTCCAGGCCCTCAAGGT
  2521 CCATCTGGGGCTCCTGGCCCACAGGGTCCTAATGGTGTGACTGGTCCAAAAGGAGCTCGT
  2581 GGTGCACAGGGACCCCCAGGTGCCACTGGATTCCCTGGTGCAGCAGGACGAGTGGGACCA
  2641 CCAGGTCCCAATGGTAATCCTGGAGCTGCTGGCCCACCAGGTGCTGCTGGGAAAGATGGC
  2701 CCCAAAGGTGCTCGTGGTGATGCAGGCCCAACTGGTCGTGCTGGTGACCCTGGTTTGCAA
  2761 GGCCCTGCTGGTGCCCCAGGCGAGAAGGGAGACTCTGGCGAAGATGGCCCTCCTGGTGCT
  2821 GATGGCCCACCTGGACCTCAAGGTTTGGCTGGTCAAAGAGGCATTGTAGGTCTCCCTGGA
  2881 CAGCGTGGTGAGAGAGGCTTCCCTGGACTGCCTGGTCCTTCTGGTGAGCCTGGCAAACAA
  2941 GGAGCTTCTGGTGGTCCTGGTGACAGAGGCCCCCCTGGCCCCGTTGGCCCCCCTGGTCTG
  3001 ACTGGTCCCTCTGGTGAACCTGGACGTGAGGGCAATCCTGGTGCAGATGGTCCCCCTGGA
  3061 AGAGATGGTTCTGCTGGAGTGAAAGGTGATCGTGGTGAGACTGGTCCTGCTGGTGGCCCT
  3121 GGTGCTCCTGGCCCACCTGGCTCTCCAGGCCCTGTTGGACCAACTGGCAAACAAGGAGAC
  3181 AGAGGCGAATCAGGTGCTCAAGGTCCATTGGGTCCAGCTGGCCCTGCAGGGGCACGTGGC
  3241 ATGCCTGGTCCACAAGGTCCTCGTGGTGACAAGGGTGAAGCTGGCGAGGCAGGAGAGCGT
  3301 GGTCTGAAGGGACACAGAGGATTCACTGGTCTTCAGGGTCTTCCTGGACCTCCTGGTCCT
  3361 TCTGGAGATCAAGGGGCAAGTGGTCCTTCTGGTCCCTCTGGCCCCAGGGGTCCCCCAGGC
  3421 CCTGTTGGCCCCTCTGGCAAAGATGGCTCCAACGGGATGCCTGGTCCAATTGGTCCTCCT
  3481 GGTCCACGTGGTCGTAGTGGTGAAACTGGCCCTGCTGGTCCTCCTGGAAATCCTGGACCT
  3541 CCTGGTCCTCCCGGCCCTCCTGGTCCTGGTATTGACATGTCAGCCTTTGCTGGCCTGGGC
  3601 GGGAGGGAGAAAGGCCCTGATCCTCTCCGTTACATGCGAGATGACCAATCTTCTGGTAAC
  3661 CTGAGGCAGCATGATGTTGAGGTCGACGCTACCCTGAAGTCCCTGAACAACCAGATTGAA
  3721 AGCATCCGAAGTCCAGAAGGCAGCAGGAAAAACCCAGCTCGTACCTGCCGTGACCTGAAA
  3781 CTCTGCCACCCTGAATGGAAGAGTGGTGACTATTGGATTGATCCTAACCAGGGCTGCACT
  3841 TTGGATGCTATCAAGGTTTTCTGCAATATGGAGACTGGAGAGACTTGTGTCTATCCCAAG
  3901 CCTAGTAGCATTCCCAAGAAGAACTGGTGGACAAGCAAGAGCAAGGATAAGAAGCATGTC
  3961 TGGTTTGGAGAGACCATCAATGGAGGTTTCCACTTTAGCTATGGAGATGACAACCTGGCT
  4021 CCTAACACTGCCAACATCCAGATGACTTTCCTGCGCCTCTTGTCAACGGAAGGCTCACAG
  4081 AACCTCACCTACCACTGCAAGAACAGCATTGCCTACATGGACGAGGCCTCTGGGAACCTT
  4141 AAGAAAGCTCTCCTGATCCAGGGATCCAATGATGTGGAGATCAGAGCTGAGGGCAACAGC
  4201 AGGTTTACATACAGTGCCTTGCAGGATGGCTGCACGAAACACACTGGCAAATGGGGTAAG
  4261 ACAATAATTGAATACAGATCACAGAAGACCTCACGCCTGCCCATCGTTGACATTGCGCCT
  4321 ATGGACATTGGTGGAGCTGATCAGGAATTCGGCGTTGACATTGGCCCCGTGTGCTTTTTG
  4381 TAA

Predicted Protein Product
EEAGNCVQDGQRYSDKDVWKPEPCRICVCDTGTVLCDDILCEEMRDCPNPEIPFGECCPI
CPTDQPTTSGRQPGPKGQKGEPGDIKDVVGPRGPLGPQGPSGEQGPRGERGDKGEKKGTP
GPRGRDGEPGTPGNPGPPGPPGPPGPPGLGGNFGAQMAGGFDEKAGGAQMGVMQGPMGPM
GPRGPPGPPGSPGPQGFQGSPGEPGESGTSGPMGPGPPGPPGKPGDDGEAGKPGKSGERG
LPGPQGARGFPGTPGLPGVKGHRGFPGLDGSKGEAGAPGAKGESGSAGENGSPGPMGPRG
LPGERGRPGSSGAAGARGNDGLPGPAGPPGPVGPAGSPGFPGAPGAKGEAGPTGARGPEG
AQGSRGEPGNPGSPGPSGASGNPGNDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATG
PLGPKGQTGEPGIAGFKGEQGPKGEHGPAGPQGPPGPAGEEGKRGGRGEPGSAGPIGPPG
ERGAPGNRGFPGQDGLAGPKGAPGERGPPGLGGPKGASGDPGRPGEPGLPGARGLTGRPG
DAGPQGKLGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEAGKAGEKGLPGAPG
LRGLPGKDGETGAGGPPGPSGPAGERGEQGAPGPSGFQGLPGPPGPPGENGKSGDQGVPG
EAGAPGLVGPRGERGFPGERGSAGAQGLQGPRGLPGTPGTDGPKGATGPPGALGAQGPPG
LQGMPGERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLTGPIGPPGPAGGNGEKGEAG
PPGPSGAAGARGAPGDRGEPGAPGPAGFAGPPGADGQPGAKGEQGESGQKGDAGSPGPQG
PSGAPGPQGPNGVTGPKGARGAQGPPGATGFPGAAGRVGPPGPNGNPGAAGPPGAAGKDG
PKGARGDAGPTGRAGDPGLQGPAGAPGEKGDSGEDGPPGADGPPGPQGLAGQRGIVGLPG
QRGERGFPGLPGPSGEPGKQGASGGPGDRGPPGPVGPPGLTGPSGEPGREGNPGADGPPG
RDGSAGVKGDRGETGPAGGPGAPGPPGSPGPVGPTGKQGDRGESGAQGPLGPAGPAGARG
MPGPQGPRGDKGEAGEAGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPSGPSGPRGPPG
PVGPSGKDGSNGMPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLG
GREKGPDPLRYMRDDQSSGNLRQHDVEVDATLKSLNNQIESIRSPEGSRKNPARTCRDLK
LCHPEWKSGDYWIDPNQGCTLDAIKVFCNMETGETCVYPKPSSIPKKNWWTSKSKDKKHV
WFGETINGGFHFSYGDDNLAPNTANIQMTFLRLLSTEGSQNLTYHCKNSIAYMDEASGNL
KKALLIQGSNDVEIRAEGNSRFTYSALQDGCTKHTGKWGKTIIEYRSQKTSRLPIVDIAP
MDIGGADQEFGVDIGPVCFL
Protein Alignment to Mouse
sp|P28481|CO2A1_MOUSE Collagen alpha-1(II) chain OS=Mus musculus GN=Col2a1
            PE=1 SV=2
      MGI:88452 Col2a1 collagen, type II, alpha 1 (Chr 15)
        Length = 1487

 Score = 1353 (481.3 bits), Expect = 1.2e-310, Sum P(8) = 1.2e-310
 Identities = 238/270 (88%), Positives = 263/270 (97%)

Query:  1191 IDMSAFAGLGGREKGPDPLRYMRDDQSSGNLRQHDVEVDATLKSLNNQIESIRSPEGSRK 1250
             IDMSAFAGLG REKGPDP++YMR D++   LRQHDVEVDATLKSLNNQIESIRSP+GSRK
Sbjct:  1218 IDMSAFAGLGQREKGPDPMQYMRADEADSTLRQHDVEVDATLKSLNNQIESIRSPDGSRK 1277

Query:  1251 NPARTCRDLKLCHPEWKSGDYWIDPNQGCTLDAIKVFCNMETGETCVYPKPSSIPKKNWW 1310
             NPARTC+DLKLCHPEWKSGDYWIDPNQGCTLDA+KVFCNMETGETCVYP P+++P+KNWW
Sbjct:  1278 NPARTCQDLKLCHPEWKSGDYWIDPNQGCTLDAMKVFCNMETGETCVYPNPATVPRKNWW 1337

Query:  1311 TSKSKDKKHVWFGETINGGFHFSYGDDNLAPNTANIQMTFLRLLSTEGSQNLTYHCKNSI 1370
             +SKSK+KKH+WFGET+NGGFHFSYGD NLAPNTAN+QMTFLRLLSTEGSQN+TYHCKNSI
Sbjct:  1338 SSKSKEKKHIWFGETMNGGFHFSYGDGNLAPNTANVQMTFLRLLSTEGSQNITYHCKNSI 1397

Query:  1371 AYMDEASGNLKKALLIQGSNDVEIRAEGNSRFTYSALQDGCTKHTGKWGKTIIEYRSQKT 1430
             AY+DEA+GNLKKALLIQGSNDVE+RAEGNSRFTY+AL+DGCTKHTGKWGKT+IEYRSQKT
Sbjct:  1398 AYLDEAAGNLKKALLIQGSNDVEMRAEGNSRFTYTALKDGCTKHTGKWGKTVIEYRSQKT 1457

Query:  1431 SRLPIVDIAPMDIGGADQEFGVDIGPVCFL 1460
             SRLPI+DIAPMDIGGA+QEFGVDIGPVCFL
Sbjct:  1458 SRLPIIDIAPMDIGGAEQEFGVDIGPVCFL 1487

 Score = 427 (155.4 bits), Expect = 1.2e-310, Sum P(8) = 1.2e-310
 Identities = 95/198 (47%), Positives = 99/198 (50%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             GRAGDPGLQGPAGAPGEK                         IVGLPGQRGERGFPGLP
Sbjct:   939 GRAGDPGLQGPAGAPGEKGEPGDDGPSGLDGPPGPQGLAGQRGIVGLPGQRGERGFPGLP 998

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKGDR 1031
             GPSGEPGKQGA                       EPGREG+PGADGPPGRDG+AGVKGDR
Sbjct:   999 GPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDR 1058

Query:  1032 XXXXXXXXXXXXXXXXXXXXXXXXXKQGDRGESXXXXXXXXXXXXXXXXXXXXXXXXXDK 1091
                                      KQGDRGE+                         DK
Sbjct:  1059 GETGALGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIAGPQGPRGDK 1118

Query:  1092 GEAGEAGERGLKGHRGFT 1109
             GE+GE GERGLKGHRGFT
Sbjct:  1119 GESGEQGERGLKGHRGFT 1136

 Score = 419 (152.6 bits), Expect = 1.2e-310, Sum P(8) = 1.2e-310
 Identities = 85/166 (51%), Positives = 96/166 (57%)

Query:     1 EEAGNCVQDGQRYSDKDVWKPEPCRICVCDTGTVLCDDILCEEMRDCPNPEIPFGECCPI 60
             +EAG+C+Q+GQRY DKDVWKP  CRICVCDTG VLCDDI+CE+  DC NPEIPFGECCPI
Sbjct:    29 QEAGSCLQNGQRYKDKDVWKPSSCRICVCDTGNVLCDDIICEDP-DCLNPEIPFGECCPI 87

Query:    61 CPTDQPTTSXXXXXXXXXXXXXXDIKDVVGPRGPLGPQGPSGEQXXXXXXXXXXXXXXTP 120
             CP D  T S              DI+D++GPRGP GPQGP+GEQ               P
Sbjct:    88 CPADLATASGKLGPKGQKGEPG-DIRDIIGPRGPPGPQGPAGEQGPRGDRGDKGEKGA-P 145

Query:   121 GPRGRDXXXXXXXXXXXXXXXXXXXX-XXXXXXXXAQMAGGFDEKA 165
             GPRGRD                             AQMAGG+DEKA
Sbjct:   146 GPRGRDGEPGTPGNPGPAGPPGPPGPPGLSAGNFAAQMAGGYDEKA 191

 Score = 330 (121.2 bits), Expect = 1.2e-310, Sum P(8) = 1.2e-310
 Identities = 68/127 (53%), Positives = 70/127 (55%)

Query:   425 KGQTGEPGIAGFKGEQGPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPGERGA 484
             KGQ GEPGIAGFKG+QGPK                                  PPGERGA
Sbjct:   452 KGQAGEPGIAGFKGDQGPKGETGPAGPQGAPGPAGEEGKRGARGEPGGAGPIGPPGERGA 511

Query:   485 PGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRPGDAGP 544
             PGNRGFPGQDGLAGPK                      RPGEPGLPGARGLTGRPGDAGP
Sbjct:   512 PGNRGFPGQDGLAGPKGAPGERGPSGLTGPKGANGDPGRPGEPGLPGARGLTGRPGDAGP 571

Query:   545 QGKLGPS 551
             QGK+GPS
Sbjct:   572 QGKVGPS 578

 Score = 195 (73.7 bits), Expect = 1.2e-310, Sum P(8) = 1.2e-310
 Identities = 34/35 (97%), Positives = 35/35 (100%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPGLD 269
             KSGERGLPGPQGARGFPGTPGLPGVKGHRG+PGLD
Sbjct:   262 KSGERGLPGPQGARGFPGTPGLPGVKGHRGYPGLD 296

 Score = 179 (68.1 bits), Expect = 1.2e-310, Sum P(8) = 1.2e-310
 Identities = 33/35 (94%), Positives = 33/35 (94%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             ERGAAGI GPKGDRGDVGEKGPEGAPGKDG RGLT
Sbjct:   754 ERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLT 788

 Score = 144 (55.7 bits), Expect = 3.6e-218, Sum P(5) = 3.6e-218
 Identities = 39/121 (32%), Positives = 45/121 (37%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G AG PG++G +G+PGE                            G  GQ G  G PG  
Sbjct:   300 GEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPV 359

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPG---ADGPPGRDGSAGVK 1028
             GP+G PG  GA                       EPG  G+PG   A G PG DG  G K
Sbjct:   360 GPAGGPGFPGAPGAKGEAGPTGARGPEGAQGSRGEPGNPGSPGPAGASGNPGTDGIPGAK 419

Query:  1029 G 1029
             G
Sbjct:   420 G 420

 Score = 138 (53.6 bits), Expect = 6.1e-273, Sum P(7) = 6.1e-273
 Identities = 40/128 (31%), Positives = 46/128 (35%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G  G  G  G  GAPGE+                           G  GQ+G+ G PG  
Sbjct:   807 GPPGPSGSTGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGDQGEAGQKGDAGAPGPQ 866

Query:   972 GPSGEPGKQGASXXXXXXXXXXX------XXXXXXXXXXXEPGREGNPGADGPPG---RD 1022
             GPSG PG QG +                             PG  GNPG  GPPG   +D
Sbjct:   867 GPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGANGNPGPAGPPGPAGKD 926

Query:  1023 GSAGVKGD 1030
             G  GV+GD
Sbjct:   927 GPKGVRGD 934

 Score = 135 (52.6 bits), Expect = 3.1e-258, Sum P(7) = 3.1e-258
 Identities = 41/130 (31%), Positives = 47/130 (36%)

Query:   911 TGRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGE------ 964
             TG AG PG  GPAG  GE+                           G+PG+ G       
Sbjct:   638 TGAAGPPGPSGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKQGDQGIPGEAGAPGLVGP 697

Query:   965 RGFPGLPGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGS 1024
             RG  G PG  G PG QG                         PG +G PG  G PG  G+
Sbjct:   698 RGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGAAGPDGPPGAQGPPGLQGMPGERGA 757

Query:  1025 AGV---KGDR 1031
             AG+   KGDR
Sbjct:   758 AGIAGPKGDR 767

 Score = 126 (49.4 bits), Expect = 6.9e-236, Sum P(7) = 6.9e-236
 Identities = 37/120 (30%), Positives = 44/120 (36%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             GR G+PGL G  G  G                             G  GQ G  GFPG  
Sbjct:   549 GRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPK 608

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKGDR 1031
             G +GEPGK G                         PG++G  GA GPPG  G AG +G++
Sbjct:   609 GANGEPGKAGEKGLAGAPGLRGL------------PGKDGETGAAGPPGPSGPAGERGEQ 656

 Score = 124 (48.7 bits), Expect = 1.0e-202, Sum P(5) = 1.0e-202
 Identities = 36/120 (30%), Positives = 41/120 (34%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G AG PG QG  G PGE                            G PG+ GERG PG  
Sbjct:   213 GPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPAGKPGDDGEAGKPGKSGERGLPGPQ 272

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKGDR 1031
             G  G PG  G                          G  G+PG +G PG  G  G+ G+R
Sbjct:   273 GARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGER 332

 Score = 121 (47.7 bits), Expect = 3.7e-271, Sum P(7) = 3.7e-271
 Identities = 37/119 (31%), Positives = 40/119 (33%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G AG PG QGP+GAPG +                           G  G  G  G PG  
Sbjct:   858 GDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGANGNPGPA 917

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKGD 1030
             GP G  GK G                         PGR G+PG  GP G  G  G  GD
Sbjct:   918 GPPGPAGKDGPKGVRGDSG---------------PPGRAGDPGLQGPAGAPGEKGEPGD 961

 Score = 121 (47.7 bits), Expect = 1.8e-225, Sum P(6) = 1.8e-225
 Identities = 35/122 (28%), Positives = 41/122 (33%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G AG  G +GP GA G +                           G  G  G  G PG P
Sbjct:   375 GEAGPTGARGPEGAQGSRGEPGNPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFP 434

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXX---EPGREGNPGADGPPGRDGSAGVK 1028
             GP G PG QGA+                         E G  G  GA GP G +G  G +
Sbjct:   435 GPRGPPGPQGATGPLGPKGQAGEPGIAGFKGDQGPKGETGPAGPQGAPGPAGEEGKRGAR 494

Query:  1029 GD 1030
             G+
Sbjct:   495 GE 496

 Score = 119 (46.9 bits), Expect = 3.0e-256, Sum P(7) = 3.0e-256
 Identities = 36/120 (30%), Positives = 42/120 (35%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G+AG+ GL   AGAPG +                           G PG  G +G PG P
Sbjct:   615 GKAGEKGL---AGAPGLRGLPGKDGETGAAGPPGPSGPAGERGEQGAPGPSGFQGLPGPP 671

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKGDR 1031
             GP GE GKQG                        E G  G  G  GP G  G+ G  G +
Sbjct:   672 GPPGEGGKQGDQGIPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPK 731

 Score = 119 (46.9 bits), Expect = 3.7e-233, Sum P(7) = 3.7e-233
 Identities = 38/131 (29%), Positives = 48/131 (36%)

Query:   912 GRAGDPGL------QGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRG-- 963
             G+AG+PG+      QGP G  G                            +G PG+RG  
Sbjct:   453 GQAGEPGIAGFKGDQGPKGETGPAGPQGAPGPAGEEGKRGARGEPGGAGPIGPPGERGAP 512

Query:   964 -ERGFPG---LPGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPP 1019
               RGFPG   L GP G PG++G S                        G  G PG  GP 
Sbjct:   513 GNRGFPGQDGLAGPKGAPGERGPSGLTGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQ 572

Query:  1020 GRDGSAGVKGD 1030
             G+ G +G  G+
Sbjct:   573 GKVGPSGAPGE 583

 Score = 119 (46.9 bits), Expect = 1.7e-231, Sum P(7) = 1.7e-231
 Identities = 31/76 (40%), Positives = 35/76 (46%)

Query:   479 PGERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGR 538
             PG  G+PG  G PG+DG AG K                       PG PG PG  G TG+
Sbjct:  1034 PGREGSPGADGPPGRDGAAGVKGDRGETGALGAPGA---------PGPPGSPGPAGPTGK 1084

Query:   539 PGD---AGPQGKLGPS 551
              GD   AG QG +GPS
Sbjct:  1085 QGDRGEAGAQGPMGPS 1100

 Score = 117 (46.2 bits), Expect = 4.2e-265, Sum P(8) = 4.2e-265
 Identities = 37/123 (30%), Positives = 40/123 (32%)

Query:   912 GRAGDPGLQGPAGA---PGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFP 968
             G  G PG QGP G    PGE+                           G PG+ G RG  
Sbjct:   735 GPDGPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPE------GAPGKDGGRGLT 788

Query:   969 GLPGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVK 1028
             G  GP G  G  G                        E G  G  G  GPPG DG  G K
Sbjct:   789 GPIGPPGPAGANGEKGEVGPPGPSGSTGARGAPGERGETGPPGPAGFAGPPGADGQPGAK 848

Query:  1029 GDR 1031
             GD+
Sbjct:   849 GDQ 851

 Score = 114 (45.2 bits), Expect = 8.6e-234, Sum P(7) = 8.6e-234
 Identities = 36/128 (28%), Positives = 40/128 (31%)

Query:   425 KGQTGEPGIAGFKGEQGPKXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXPPGE 481
             +G+ G+ G AG  G QGP                                      PPG 
Sbjct:   851 QGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPGA 910

Query:   482 RGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRPGD 541
              G PG  G PG  G  GPK                       PGE G PG  G +G  G 
Sbjct:   911 NGNPGPAGPPGPAGKDGPKGVRGDSGPPGRAGDPGLQGPAGAPGEKGEPGDDGPSGLDGP 970

Query:   542 AGPQGKLG 549
              GPQG  G
Sbjct:   971 PGPQGLAG 978

 Score = 114 (45.2 bits), Expect = 8.5e-232, Sum P(7) = 8.5e-232
 Identities = 35/120 (29%), Positives = 40/120 (33%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G  G  G  GP G  GE                            G  G+RG RG PG  
Sbjct:   441 GPQGATGPLGPKGQAGEPGIAGFKGDQGPKGETGPAGPQGAPGPAGEEGKRGARGEPGGA 500

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKGDR 1031
             GP G PG++GA                         G  G  GA+G PGR G  G+ G R
Sbjct:   501 GPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLTGPKGANGDPGRPGEPGLPGAR 560

 Score = 113 (44.8 bits), Expect = 7.2e-288, Sum P(8) = 7.2e-288
 Identities = 26/72 (36%), Positives = 30/72 (41%)

Query:   479 PGERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGR 538
             PG  GAPG +G  G  G  GP+                       PG  G+PGA+G  G 
Sbjct:   365 PGFPGAPGAKGEAGPTGARGPEGAQGSRGEPGNPGSPGPAGASGNPGTDGIPGAKGSAGA 424

Query:   539 PGDAGPQGKLGP 550
             PG AG  G  GP
Sbjct:   425 PGIAGAPGFPGP 436

 Score = 113 (44.8 bits), Expect = 5.1e-274, Sum P(8) = 5.1e-274
 Identities = 30/79 (37%), Positives = 33/79 (41%)

Query:   478 PPGERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGL---PGARG 534
             P GERG PG RG PG  GL GP+                        G PGL   PG RG
Sbjct:   697 PRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGAAGPDGPPGAQGPPGLQGMPGERG 756

Query:   535 ---LTGRPGDAGPQGKLGP 550
                + G  GD G  G+ GP
Sbjct:   757 AAGIAGPKGDRGDVGEKGP 775

 Score = 112 (44.5 bits), Expect = 1.4e-233, Sum P(7) = 1.4e-233
 Identities = 39/131 (29%), Positives = 43/131 (32%)

Query:   426 GQTGEPGIAGFKGEQGPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPGERGAP 485
             G  G+PG  G +GE G K                                  PPG  G P
Sbjct:   840 GADGQPGAKGDQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFP 899

Query:   486 GNRGF---PGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGL--P-GARGLTGRP 539
             G  G    PG +G  GP                       R G+PGL  P GA G  G P
Sbjct:   900 GAAGRVGPPGANGNPGPAGPPGPAGKDGPKGVRGDSGPPGRAGDPGLQGPAGAPGEKGEP 959

Query:   540 GDAGPQGKLGP 550
             GD GP G  GP
Sbjct:   960 GDDGPSGLDGP 970

 Score = 112 (44.5 bits), Expect = 1.4e-231, Sum P(7) = 1.4e-231
 Identities = 36/118 (30%), Positives = 40/118 (33%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G  G PG +G AGAPG                             G PG  G +G  G  
Sbjct:   411 GTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPKGQAGEPGIAGFKGDQGPK 470

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKG 1029
             G +G  G QGA                        PG  G PG  G PG+DG AG KG
Sbjct:   471 GETGPAGPQGAPGPAGEEGKRGARGEPGGAGPIGPPGERGAPGNRGFPGQDGLAGPKG 528

 Score = 112 (44.5 bits), Expect = 9.8e-162, Sum P(4) = 9.8e-162
 Identities = 34/119 (28%), Positives = 40/119 (33%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVG-LPGQRGERGFPGL 970
             G  G PG  GPAG PG                            +G + G  G  G  G 
Sbjct:   152 GEPGTPGNPGPAGPPGPPGPPGLSAGNFAAQMAGGYDEKAGGAQMGVMQGPMGPMGPRGP 211

Query:   971 PGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKG 1029
             PGP+G PG QG                         PG  G PG DG  G+ G +G +G
Sbjct:   212 PGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRG---PPGPAGKPGDDGEAGKPGKSGERG 267

 Score = 111 (44.1 bits), Expect = 2.5e-232, Sum P(7) = 2.5e-232
 Identities = 33/119 (27%), Positives = 40/119 (33%)

Query:   911 TGRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGL 970
             TG AG  G  GPAG  G++                           G  G  G +G PG 
Sbjct:   473 TGPAGPQGAPGPAGEEGKRGARGEPGGAGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGE 532

Query:   971 PGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKG 1029
              GPSG  G +GA+                      + G +G  G  G PG DG  G  G
Sbjct:   533 RGPSGLTGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGEDGRPGPPG 591

 Score = 110 (43.8 bits), Expect = 1.0e-284, Sum P(8) = 1.0e-284
 Identities = 29/76 (38%), Positives = 34/76 (44%)

Query:   478 PPGERGAPGNRGFPGQ---DGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARG 534
             PPGE G  G++G PG+    GL GP+                       PG  GL G RG
Sbjct:   673 PPGEGGKQGDQGIPGEAGAPGLVGPRGERGFPGERGS------------PGAQGLQGPRG 720

Query:   535 LTGRPGDAGPQGKLGP 550
             L G PG  GP+G  GP
Sbjct:   721 LPGTPGTDGPKGAAGP 736

 Score = 110 (43.8 bits), Expect = 7.1e-257, Sum P(7) = 7.1e-257
 Identities = 36/128 (28%), Positives = 42/128 (32%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G+ GD G+ G AGAPG                           + G PG  G +G  G  
Sbjct:   678 GKQGDQGIPGEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGAAGPD 737

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADG---------PPGRD 1022
             GP G  G  G                        E G EG PG DG         PPG  
Sbjct:   738 GPPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPA 797

Query:  1023 GSAGVKGD 1030
             G+ G KG+
Sbjct:   798 GANGEKGE 805

 Score = 110 (43.8 bits), Expect = 8.6e-222, Sum P(6) = 8.6e-222
 Identities = 34/120 (28%), Positives = 38/120 (31%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G  G+ G  GPAG PG                             G  G RGE G PG P
Sbjct:   342 GARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGSRGEPGNPGSP 401

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKGDR 1031
             GP+G  G  G                          G  G PG  GPPG  G+ G  G +
Sbjct:   402 GPAGASGNPGTDGIPGAKGSAGAPGIA---------GAPGFPGPRGPPGPQGATGPLGPK 452

 Score = 108 (43.1 bits), Expect = 3.6e-277, Sum P(8) = 3.6e-277
 Identities = 36/119 (30%), Positives = 39/119 (32%)

Query:   911 TGRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGL 970
             TG+ GD G  G  G  G                             GL G RG  G  GL
Sbjct:  1082 TGKQGDRGEAGAQGPMGPSGPAGARGIAGPQGPRGDKGESGEQGERGLKGHRGFTGLQGL 1141

Query:   971 PGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKG 1029
             PGP G  G QGAS                      + G  G PG  GPPG  G +G  G
Sbjct:  1142 PGPPGPSGDQGASGPAGPSGPRGPPGPVGPSG---KDGSNGIPGPIGPPGPRGRSGETG 1197

 Score = 108 (43.1 bits), Expect = 8.7e-270, Sum P(7) = 8.7e-270
 Identities = 36/120 (30%), Positives = 40/120 (33%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G+ G  GL GP G PG                             G PG+RGE G PG  
Sbjct:   780 GKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPSGSTGAR------GAPGERGETGPPGPA 833

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVKGDR 1031
             G +G PG  G                         PG +G  GA GP G  G  G KG R
Sbjct:   834 GFAGPPGADGQPGAKGDQGEAGQKGDAGA------PGPQGPSGAPGPQGPTGVTGPKGAR 887

 Score = 108 (43.1 bits), Expect = 2.3e-233, Sum P(7) = 2.3e-233
 Identities = 26/73 (35%), Positives = 30/73 (41%)

Query:   479 PGERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGR 538
             PG+ G  G  G PG  GLAG +                       PG+ G PGA G  G 
Sbjct:   959 PGDDGPSGLDGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGP 1018

Query:   539 PGDAGPQGKLGPS 551
             PG  GP G  GP+
Sbjct:  1019 PGPVGPPGLTGPA 1031

 Score = 107 (42.7 bits), Expect = 3.5e-259, Sum P(7) = 3.5e-259
 Identities = 35/123 (28%), Positives = 40/123 (32%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G  GD G +GP GAPG+                           VG PG  G  G  G P
Sbjct:   765 GDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGE---VGPPGPSGSTGARGAP 821

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGP---PGRDGSAGVK 1028
             G  GE G  G +                      + G  G PG  GP   PG  G  GV 
Sbjct:   822 GERGETGPPGPAGFAGPPGADGQPGAKGDQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVT 881

Query:  1029 GDR 1031
             G +
Sbjct:   882 GPK 884

 Score = 106 (42.4 bits), Expect = 5.9e-277, Sum P(8) = 5.9e-277
 Identities = 33/122 (27%), Positives = 40/122 (32%)

Query:   911 TGRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGL 970
             TG  G PG  GP G+PG                             G+ G +G RG  G 
Sbjct:  1061 TGALGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIAGPQGPRGDKGE 1120

Query:   971 PGPSGE---PGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGV 1027
              G  GE    G +G +                        G  G PG  GP G+DGS G+
Sbjct:  1121 SGEQGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGSNGI 1180

Query:  1028 KG 1029
              G
Sbjct:  1181 PG 1182

 Score = 106 (42.4 bits), Expect = 4.7e-267, Sum P(7) = 4.7e-267
 Identities = 25/76 (32%), Positives = 31/76 (40%)

Query:   478 PPGERGAPGNRGFPGQDGLAGPKXXXXXXX---XXXXXXXXXXXXXXXRPGEPGLPGARG 534
             PPG  G+ G RG PG+ G  GP                          + G+ G PG +G
Sbjct:   808 PPGPSGSTGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGDQGEAGQKGDAGAPGPQG 867

Query:   535 LTGRPGDAGPQGKLGP 550
              +G PG  GP G  GP
Sbjct:   868 PSGAPGPQGPTGVTGP 883

 Score = 105 (42.0 bits), Expect = 3.4e-301, Sum P(8) = 3.4e-301
 Identities = 19/32 (59%), Positives = 21/32 (65%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             G  G PGP GA G PGT G+PG KG  G PG+
Sbjct:   396 GNPGSPGPAGASGNPGTDGIPGAKGSAGAPGI 427

 Score = 105 (42.0 bits), Expect = 3.4e-209, Sum P(6) = 3.4e-209
 Identities = 26/73 (35%), Positives = 29/73 (39%)

Query:   957 GLPGQRGERGFPGLPGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGAD 1016
             GLPG +G RGFPG PG  G  G +G                         PG  G+PG  
Sbjct:   267 GLPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGS---PGENGSPGPM 323

Query:  1017 GPPGRDGSAGVKG 1029
             GP G  G  G  G
Sbjct:   324 GPRGLPGERGRTG 336

 Score = 104 (41.7 bits), Expect = 4.4e-289, Sum P(9) = 4.4e-289
 Identities = 29/77 (37%), Positives = 32/77 (41%)

Query:   480 GERGAPGNRGFPGQDG---LAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLT 536
             G  GAPG RG PG+DG    AGP                        PG PG PG  G  
Sbjct:   621 GLAGAPGLRGLPGKDGETGAAGPPGPSGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKQ 680

Query:   537 GR---PGDAGPQGKLGP 550
             G    PG+AG  G +GP
Sbjct:   681 GDQGIPGEAGAPGLVGP 697

 Score = 104 (41.7 bits), Expect = 6.5e-274, Sum P(8) = 6.5e-274
 Identities = 20/33 (60%), Positives = 21/33 (63%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             + G  G PGPQGARG PG  G PG KG  G PG
Sbjct:   583 EDGRPGPPGPQGARGQPGVMGFPGPKGANGEPG 615

 Score = 104 (41.7 bits), Expect = 1.5e-216, Sum P(6) = 1.5e-216
 Identities = 21/33 (63%), Positives = 22/33 (66%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             SG  G PGPQG  G  G  GLPG +G RGFPGL
Sbjct:   965 SGLDGPPGPQGLAGQRGIVGLPGQRGERGFPGL 997

 Score = 102 (41.0 bits), Expect = 1.5e-276, Sum P(8) = 1.5e-276
 Identities = 34/121 (28%), Positives = 36/121 (29%)

Query:   912 GRAGDPGLQGPAG---APGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFP 968
             GR G PG  GP G   A G K                           G  G RGE G  
Sbjct:  1035 GREGSPGADGPPGRDGAAGVKGDRGETGALGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQ 1094

Query:   969 GLPGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAGVK 1028
             G  GPSG  G +G +                        G  G  G  GPPG  G  G  
Sbjct:  1095 GPMGPSGPAGARGIAGPQGPRGDKGESGEQGERGLKGHRGFTGLQGLPGPPGPSGDQGAS 1154

Query:  1029 G 1029
             G
Sbjct:  1155 G 1155

 Score = 102 (41.0 bits), Expect = 9.6e-267, Sum P(7) = 9.6e-267
 Identities = 27/78 (34%), Positives = 33/78 (42%)

Query:   478 PPGERGAPGNRGF------PGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPG 531
             PPG  GAPG +GF      PG+ G++GP                       + GE GLPG
Sbjct:   211 PPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPAGKPGDDGEAGKPGKSGERGLPG 270

Query:   532 ARGLTGRPGDAGPQGKLG 549
              +G  G PG  G  G  G
Sbjct:   271 PQGARGFPGTPGLPGVKG 288

 Score = 101 (40.6 bits), Expect = 1.3e-286, Sum P(8) = 1.3e-286
 Identities = 27/75 (36%), Positives = 30/75 (40%)

Query:   479 PGERGAPGN---RGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGL 535
             PGE G+PG    RG PG+ G  GP                         G PG PGA   
Sbjct:   314 PGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGA--- 370

Query:   536 TGRPGDAGPQGKLGP 550
              G  G+AGP G  GP
Sbjct:   371 PGAKGEAGPTGARGP 385

 Score = 101 (40.6 bits), Expect = 2.7e-278, Sum P(7) = 2.7e-278
 Identities = 36/131 (27%), Positives = 40/131 (30%)

Query:   425 KGQTGEPGIAGF---KGEQGPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPGE 481
             +G  G+PG+ GF   KG  G                                    P GE
Sbjct:   593 QGARGQPGVMGFPGPKGANGEPGKAGEKGLAGAPGLRGLPGKDGETGAAGPPGPSGPAGE 652

Query:   482 RG---APGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGR 538
             RG   APG  GF G  G  GP                         GE G PG RG  G 
Sbjct:   653 RGEQGAPGPSGFQGLPGPPGPPGEGGKQGDQGIPGEAGAPGLVGPRGERGFPGERGSPGA 712

Query:   539 PGDAGPQGKLG 549
              G  GP+G  G
Sbjct:   713 QGLQGPRGLPG 723

 Score = 101 (40.6 bits), Expect = 8.4e-276, Sum P(8) = 8.4e-276
 Identities = 30/82 (36%), Positives = 35/82 (42%)

Query:   479 PGERGAPGNRGFPGQDGL---AGPKXXXXXXXXXXXXXXXXXXXXXXRPGE-----P-GL 529
             PG  G  G+RG+PG DG    AG                         PGE     P G 
Sbjct:   281 PGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRTGPAGA 340

Query:   530 PGARGLTGRPGDAGPQGKLGPS 551
              GARG  G+PG AGP G +GP+
Sbjct:   341 AGARGNDGQPGPAGPPGPVGPA 362

 Score = 101 (40.6 bits), Expect = 9.4e-216, Sum P(5) = 9.4e-216
 Identities = 35/126 (27%), Positives = 38/126 (30%)

Query:   426 GQTGEPGIAGFKGEQGPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPGERGAP 485
             G  G PG AG  G+QG +                                    GERG  
Sbjct:  1071 GPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGARGIAGPQGPRGDKGESGEQGERGLK 1130

Query:   486 GNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRPGDAGPQ 545
             G+RGF G  GL GP                        PG  G  G  G  G PG  GP 
Sbjct:  1131 GHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPRGP---PGPVGPSGKDGSNGIPGPIGPP 1187

Query:   546 GKLGPS 551
             G  G S
Sbjct:  1188 GPRGRS 1193

 Score = 100 (40.3 bits), Expect = 2.5e-276, Sum P(8) = 2.5e-276
 Identities = 32/116 (27%), Positives = 37/116 (31%)

Query:   911 TGRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGL 970
             +G AG  G+ GP G  G+K                           G  G +G  G  G 
Sbjct:  1100 SGPAGARGIAGPQGPRGDKGESGEQGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGP 1159

Query:   971 PGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNPGADGPPGRDGSAG 1026
              GP G PG  G S                      E G  G PG+ GPPG  G  G
Sbjct:  1160 SGPRGPPGPVGPSGKDGSNGIPGPIGPPGPRGRSGETGPVGPPGSPGPPGPPGPPG 1215

 Score = 100 (40.3 bits), Expect = 3.5e-257, Sum P(7) = 3.5e-257
 Identities = 19/31 (61%), Positives = 21/31 (67%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GE+G PGP+G  G PGTPG PG  G  G PG
Sbjct:   140 GEKGAPGPRGRDGEPGTPGNPGPAGPPGPPG 170

 Score = 100 (40.3 bits), Expect = 1.9e-256, Sum P(7) = 1.9e-256
 Identities = 19/33 (57%), Positives = 22/33 (66%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             GA GI GP+G RGD GE G +G  G  G+RG T
Sbjct:  1104 GARGIAGPQGPRGDKGESGEQGERGLKGHRGFT 1136

 Score = 100 (40.3 bits), Expect = 9.4e-216, Sum P(5) = 9.4e-216
 Identities = 31/125 (24%), Positives = 37/125 (29%)

Query:   426 GQTGEPGIAGFKGEQGPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPGERGAP 485
             G  G  G AG KG++G                                    P G  G  
Sbjct:  1044 GPPGRDGAAGVKGDRGETGALGAPGAPGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPA 1103

Query:   486 GNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRPGDAGPQ 545
             G RG  G  G  G K                       PG PG  G +G +G  G +GP+
Sbjct:  1104 GARGIAGPQGPRGDKGESGEQGERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAGPSGPR 1163

Query:   546 GKLGP 550
             G  GP
Sbjct:  1164 GPPGP 1168

 Score = 100 (40.3 bits), Expect = 2.6e-197, Sum P(4) = 2.6e-197
 Identities = 19/32 (59%), Positives = 22/32 (68%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +G AG  GP+GDRGD GEKG  G  G+DG  G
Sbjct:   124 QGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPG 155

 Score = 98 (39.6 bits), Expect = 6.5e-292, Sum P(9) = 6.5e-292
 Identities = 28/79 (35%), Positives = 30/79 (37%)

Query:   478 PPGERGAPGNRGFPG------QDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPG 531
             P G RG PG  GFPG      + G AG K                       PG  G  G
Sbjct:   592 PQGARGQPGVMGFPGPKGANGEPGKAGEKGLAGAPGLRGLPGKDGETGAAGPPGPSGPAG 651

Query:   532 ARGLTGRPGDAGPQGKLGP 550
              RG  G PG +G QG  GP
Sbjct:   652 ERGEQGAPGPSGFQGLPGP 670

 Score = 98 (39.6 bits), Expect = 2.7e-286, Sum P(8) = 2.7e-286
 Identities = 24/70 (34%), Positives = 25/70 (35%)

Query:   480 GERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRP 539
             G  GA G+RG PG  G  GP                         G PG PG RG  G  
Sbjct:   384 GPEGAQGSRGEPGNPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQ 443

Query:   540 GDAGPQGKLG 549
             G  GP G  G
Sbjct:   444 GATGPLGPKG 453

 Score = 98 (39.6 bits), Expect = 1.7e-275, Sum P(8) = 1.7e-275
 Identities = 28/74 (37%), Positives = 32/74 (43%)

Query:   480 GERGAPGN---RGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLT 536
             GERG PG    RGFPG  GL G K                        GE G PG +G +
Sbjct:   264 GERGLPGPQGARGFPGTPGLPGVKGHRGYPGLDGAK------------GEAGAPGVKGES 311

Query:   537 GRPGDAGPQGKLGP 550
             G PG+ G  G +GP
Sbjct:   312 GSPGENGSPGPMGP 325

 Score = 98 (39.6 bits), Expect = 1.3e-257, Sum P(6) = 1.3e-257
 Identities = 34/126 (26%), Positives = 38/126 (30%)

Query:   426 GQTGEPGIAGFKGEQGPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPGERGAP 485
             G TG  G  G +GE GP                                   P G  GAP
Sbjct:   813 GSTGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGDQGEAGQKGDAGAPGPQGPSGAP 872

Query:   486 GNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRPGDAGPQ 545
             G +G P   G+ GPK                       PG  G PG  G  G  G  GP+
Sbjct:   873 GPQG-P--TGVTGPKGARGAQGPPGATGFPGAAGRVGPPGANGNPGPAGPPGPAGKDGPK 929

Query:   546 GKLGPS 551
             G  G S
Sbjct:   930 GVRGDS 935

 Score = 97 (39.2 bits), Expect = 3.5e-286, Sum P(8) = 3.5e-286
 Identities = 34/125 (27%), Positives = 38/125 (30%)

Query:   425 KGQTGEPGIAGFKGEQGPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPGERGA 484
             KG++G PG  G  G  GP+                                  P G  G 
Sbjct:   308 KGESGSPGENGSPGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPG---PVGPAGG 364

Query:   485 PGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRPGDAGP 544
             PG  G PG  G AGP                        PG PG PG  G +G PG  G 
Sbjct:   365 PGFPGAPGAKGEAGP---------TGARGPEGAQGSRGEPGNPGSPGPAGASGNPGTDGI 415

Query:   545 QGKLG 549
              G  G
Sbjct:   416 PGAKG 420

 Score = 97 (39.2 bits), Expect = 4.8e-258, Sum P(6) = 4.8e-258
 Identities = 19/36 (52%), Positives = 25/36 (69%)

Query:   235 KSGERGLPGPQGARGFPG---TPGLPGVKGHRGFPG 267
             ++G  GL GP+G RGFPG   +PG  G++G RG PG
Sbjct:   688 EAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPG 723

 Score = 96 (38.9 bits), Expect = 3.0e-300, Sum P(8) = 3.0e-300
 Identities = 19/34 (55%), Positives = 21/34 (61%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPGLD 269
             +G RG  G QG+RG PG PG PG  G  G PG D
Sbjct:   380 TGARGPEGAQGSRGEPGNPGSPGPAGASGNPGTD 413

 Score = 96 (38.9 bits), Expect = 1.2e-293, Sum P(7) = 1.2e-293
 Identities = 19/34 (55%), Positives = 23/34 (67%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             E GA G+ GP+G+RG  GE+G  GA G  G RGL
Sbjct:   688 EAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGL 721

 Score = 96 (38.9 bits), Expect = 1.1e-291, Sum P(9) = 1.1e-291
 Identities = 29/80 (36%), Positives = 33/80 (41%)

Query:   479 PGERGAPGNRGFPGQ---DGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGL-----P 530
             PG+ G  G +G PG+    GL GPK                      RPG+ G      P
Sbjct:   518 PGQDGLAGPKGAPGERGPSGLTGPKGANGDPGRPGEPGLPGARGLTGRPGDAGPQGKVGP 577

Query:   531 -GARGLTGRPGDAGPQGKLG 549
              GA G  GRPG  GPQG  G
Sbjct:   578 SGAPGEDGRPGPPGPQGARG 597

 Score = 96 (38.9 bits), Expect = 1.6e-268, Sum P(7) = 1.6e-268
 Identities = 32/123 (26%), Positives = 40/123 (32%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G AG PG  G  GA G++                           G+ G +G RG  G P
Sbjct:   834 GFAGPPGADGQPGAKGDQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPP 893

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGN---PGADGPPGRDGSAGVK 1028
             G +G PG  G                          G  G+   PG  G PG  G AG  
Sbjct:   894 GATGFPGAAGRVGPPGANGNPGPAGPPGPAGKDGPKGVRGDSGPPGRAGDPGLQGPAGAP 953

Query:  1029 GDR 1031
             G++
Sbjct:   954 GEK 956

 Score = 95 (38.5 bits), Expect = 8.4e-276, Sum P(8) = 8.4e-276
 Identities = 18/31 (58%), Positives = 20/31 (64%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  GL GP+GA G PG PG PG+ G RG  G
Sbjct:   534 GPSGLTGPKGANGDPGRPGEPGLPGARGLTG 564

 Score = 95 (38.5 bits), Expect = 1.5e-262, Sum P(7) = 1.5e-262
 Identities = 17/32 (53%), Positives = 21/32 (65%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             GE+G PGP G +G PG PG PG  G +G  G+
Sbjct:   654 GEQGAPGPSGFQGLPGPPGPPGEGGKQGDQGI 685

 Score = 95 (38.5 bits), Expect = 1.3e-150, Sum P(3) = 1.3e-150
 Identities = 26/78 (33%), Positives = 32/78 (41%)

Query:   957 GLPGQRGERGFPG----LPGPSGEPGKQGASXXXXXXXXXXXXXXXXX---XXXXXEPGR 1009
             G  G +G++G PG    + GP G PG QG +                         EPG 
Sbjct:    97 GKLGPKGQKGEPGDIRDIIGPRGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGT 156

Query:  1010 EGNPGADGPPGRDGSAGV 1027
              GNPG  GPPG  G  G+
Sbjct:   157 PGNPGPAGPPGPPGPPGL 174

 Score = 94 (38.1 bits), Expect = 1.7e-291, Sum P(9) = 1.7e-291
 Identities = 24/72 (33%), Positives = 27/72 (37%)

Query:   480 GERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRP 539
             G  GAPG  G PG  G  G +                        G  G PG RGL G+ 
Sbjct:   576 GPSGAPGEDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLAGAPGLRGLPGKD 635

Query:   540 GDAGPQGKLGPS 551
             G+ G  G  GPS
Sbjct:   636 GETGAAGPPGPS 647

 Score = 94 (38.1 bits), Expect = 8.1e-272, Sum P(8) = 8.1e-272
 Identities = 28/75 (37%), Positives = 32/75 (42%)

Query:   478 PPGERGAPGNRGFPGQDG---LAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARG 534
             PPG +G PG +G PG+ G   +AGPK                        G PG  G RG
Sbjct:   739 PPGAQGPPGLQGMPGERGAAGIAGPKGDRGDVGEKGPE------------GAPGKDGGRG 786

Query:   535 LTGRPGDAGPQGKLG 549
             LTG  G  GP G  G
Sbjct:   787 LTGPIGPPGPAGANG 801

 Score = 93 (37.8 bits), Expect = 2.2e-215, Sum P(6) = 2.2e-215
 Identities = 19/35 (54%), Positives = 23/35 (65%)

Query:   236 SGERG---LPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +G+RG   LPG +G RGFPG PG  G  G +G PG
Sbjct:   977 AGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPG 1011

 Score = 93 (37.8 bits), Expect = 1.8e-196, Sum P(4) = 1.8e-196
 Identities = 20/36 (55%), Positives = 23/36 (63%)

Query:   236 SGERGLPGPQGARGFPGTPGLPG---VKGHRGFPGL 268
             +G RG+ GPQG RG  G  G  G   +KGHRGF GL
Sbjct:  1103 AGARGIAGPQGPRGDKGESGEQGERGLKGHRGFTGL 1138

 Score = 93 (37.8 bits), Expect = 2.1e-150, Sum P(3) = 2.1e-150
 Identities = 34/119 (28%), Positives = 39/119 (32%)

Query:   912 GRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGLP 971
             G  G PG QGPAG  G +                           G  G+ GE G PG P
Sbjct:   116 GPRGPPGPQGPAGEQGPRGDRGDKGEKGAP---------------GPRGRDGEPGTPGNP 160

Query:   972 GPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPG-REGNPGADGPPGRDGSAGVKG 1029
             GP+G PG  G                        + G  +G  G  GP G  G AG  G
Sbjct:   161 GPAGPPGPPGPPGLSAGNFAAQMAGGYDEKAGGAQMGVMQGPMGPMGPRGPPGPAGAPG 219

 Score = 92 (37.4 bits), Expect = 7.9e-300, Sum P(8) = 7.9e-300
 Identities = 20/34 (58%), Positives = 21/34 (61%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGH---RGFPG 267
             G  G PGPQG +G PG PG PGV G    RG PG
Sbjct:   213 GPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPG 246

 Score = 92 (37.4 bits), Expect = 4.0e-230, Sum P(7) = 4.0e-230
 Identities = 32/126 (25%), Positives = 38/126 (30%)

Query:   425 KGQTGEPGIAGFKGEQGPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPPGERGA 484
             +G+ GEPG  G  G  GP                                    P   G 
Sbjct:   148 RGRDGEPGTPGNPGPAGPPGPPGPPGLSAGNFAAQMAGGYDEKAGGAQMGVMQGP--MGP 205

Query:   485 PGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRPGDAGP 544
              G RG PG  G  GP+                       PG  G PG  G  G+PG +G 
Sbjct:   206 MGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPAGKPGDDGEAGKPGKSGE 265

Query:   545 QGKLGP 550
             +G  GP
Sbjct:   266 RGLPGP 271

 Score = 92 (37.4 bits), Expect = 2.8e-215, Sum P(6) = 2.8e-215
 Identities = 18/31 (58%), Positives = 18/31 (58%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GERG PG  G  G PG  G PG  G RG PG
Sbjct:   990 GERGFPGLPGPSGEPGKQGAPGASGDRGPPG 1020

 Score = 91 (37.1 bits), Expect = 3.5e-291, Sum P(9) = 3.5e-291
 Identities = 26/71 (36%), Positives = 26/71 (36%)

Query:   479 PGERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGR 538
             PG  G  G RG PG  G  GPK                       PG  GLPG  G TG 
Sbjct:   587 PGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGLAGA------PGLRGLPGKDGETGA 640

Query:   539 PGDAGPQGKLG 549
              G  GP G  G
Sbjct:   641 AGPPGPSGPAG 651

 Score = 91 (37.1 bits), Expect = 2.0e-157, Sum P(4) = 2.0e-157
 Identities = 26/80 (32%), Positives = 30/80 (37%)

Query:   957 GLPGQRG---ERGFPGLPGPSGEPGKQGASXXXXXXXXXXXXXXXXXXXXXXEPGREGNP 1013
             G PG RG   E G PG PGP+G PG  G                        + G    P
Sbjct:   143 GAPGPRGRDGEPGTPGNPGPAGPPGPPGPPGLSAGNFAAQMAGGYDEKAGGAQMGVMQGP 202

Query:  1014 ----GADGPPGRDGSAGVKG 1029
                 G  GPPG  G+ G +G
Sbjct:   203 MGPMGPRGPPGPAGAPGPQG 222

 Score = 90 (36.7 bits), Expect = 1.9e-285, Sum P(8) = 1.9e-285
 Identities = 23/70 (32%), Positives = 26/70 (37%)

Query:   480 GERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRP 539
             G RG PGN G PG  G +G                         PG  G PG +G TG  
Sbjct:   390 GSRGEPGNPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPL 449

Query:   540 GDAGPQGKLG 549
             G  G  G+ G
Sbjct:   450 GPKGQAGEPG 459

 Score = 90 (36.7 bits), Expect = 5.8e-275, Sum P(8) = 5.8e-275
 Identities = 17/31 (54%), Positives = 20/31 (64%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G+ G  GD G  G+ GP GAPG+DG  G
Sbjct:   558 GARGLTGRPGDAGPQGKVGPSGAPGEDGRPG 588

 Score = 90 (36.7 bits), Expect = 2.6e-257, Sum P(6) = 2.6e-257
 Identities = 18/31 (58%), Positives = 19/31 (61%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GE G  G QG  G  G PGL G +G RGFPG
Sbjct:   675 GEGGKQGDQGIPGEAGAPGLVGPRGERGFPG 705

 Score = 90 (36.7 bits), Expect = 2.6e-257, Sum P(6) = 2.6e-257
 Identities = 18/33 (54%), Positives = 20/33 (60%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGLD 269
             GERG PG QG +G  G PG PG  G +G  G D
Sbjct:   705 GERGSPGAQGLQGPRGLPGTPGTDGPKGAAGPD 737

 Score = 90 (36.7 bits), Expect = 1.4e-256, Sum P(6) = 1.4e-256
 Identities = 38/136 (27%), Positives = 44/136 (32%)

Query:   425 KGQTGEPGIAGFKG------EQGPKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXP 478
             +G+TG PG AGF G      + G K                                  P
Sbjct:   824 RGETGPPGPAGFAGPPGADGQPGAKGDQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGP 883

Query:   479 PGERGA---PGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGL 535
              G RGA   PG  GFPG  G  GP                         G+ G  G RG 
Sbjct:   884 KGARGAQGPPGATGFPGAAGRVGPPGANGNPGPAGPPGPA---------GKDGPKGVRGD 934

Query:   536 TGRPGDAGPQGKLGPS 551
             +G PG AG  G  GP+
Sbjct:   935 SGPPGRAGDPGLQGPA 950

 Score = 88 (36.0 bits), Expect = 9.7e-294, Sum P(7) = 9.7e-294
 Identities = 17/31 (54%), Positives = 20/31 (64%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G  G KGD+G+ G+KG  GAPG  G  G
Sbjct:   840 GADGQPGAKGDQGEAGQKGDAGAPGPQGPSG 870

 Score = 88 (36.0 bits), Expect = 5.4e-270, Sum P(7) = 5.4e-270
 Identities = 16/33 (48%), Positives = 20/33 (60%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E G AG  G +G +G+ G  GP+GAPG  G  G
Sbjct:   457 EPGIAGFKGDQGPKGETGPAGPQGAPGPAGEEG 489

 Score = 87 (35.7 bits), Expect = 2.6e-299, Sum P(8) = 2.6e-299
 Identities = 17/31 (54%), Positives = 18/31 (58%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GE G PG +G  G PG  G PG  G RG PG
Sbjct:   300 GEAGAPGVKGESGSPGENGSPGPMGPRGLPG 330

 Score = 87 (35.7 bits), Expect = 1.2e-293, Sum P(7) = 1.2e-293
 Identities = 17/34 (50%), Positives = 20/34 (58%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             +G  G  G KGD G  G +GP GAPG  G  G+T
Sbjct:   848 KGDQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVT 881

 Score = 87 (35.7 bits), Expect = 1.1e-292, Sum P(7) = 1.1e-292
 Identities = 16/32 (50%), Positives = 19/32 (59%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G  G  GP G  G  GE+G +GAPG  G +GL
Sbjct:   636 GETGAAGPPGPSGPAGERGEQGAPGPSGFQGL 667

 Score = 87 (35.7 bits), Expect = 6.8e-270, Sum P(7) = 6.8e-270
 Identities = 19/35 (54%), Positives = 21/35 (60%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             ERG +G+ GPKG  GD G  G  G PG    RGLT
Sbjct:   532 ERGPSGLTGPKGANGDPGRPGEPGLPGA---RGLT 563

 Score = 86 (35.3 bits), Expect = 3.4e-299, Sum P(8) = 3.4e-299
 Identities = 17/31 (54%), Positives = 17/31 (54%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G RG PGP G  G  G  G PG  G RG PG
Sbjct:   240 GPRGPPGPAGKPGDDGEAGKPGKSGERGLPG 270

 Score = 86 (35.3 bits), Expect = 8.6e-268, Sum P(7) = 8.6e-268
 Identities = 19/36 (52%), Positives = 20/36 (55%)

Query:   237 GERGLPGPQGARGFPGTPG---LPGVKGHRGFPGLD 269
             G  G PGP+GA G PG  G   L G  G RG PG D
Sbjct:   600 GVMGFPGPKGANGEPGKAGEKGLAGAPGLRGLPGKD 635

 Score = 85 (35.0 bits), Expect = 4.3e-299, Sum P(8) = 4.3e-299
 Identities = 16/31 (51%), Positives = 19/31 (61%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G+PG +G+ G PG  G PG  G RG PG
Sbjct:   411 GTDGIPGAKGSAGAPGIAGAPGFPGPRGPPG 441

 Score = 85 (35.0 bits), Expect = 4.3e-299, Sum P(8) = 4.3e-299
 Identities = 17/31 (54%), Positives = 17/31 (54%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G PGP G  G PG PG PG KG  G  G
Sbjct:   351 GPAGPPGPVGPAGGPGFPGAPGAKGEAGPTG 381

 Score = 85 (35.0 bits), Expect = 4.3e-299, Sum P(8) = 4.3e-299
 Identities = 17/31 (54%), Positives = 18/31 (58%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GE G+ GP G RG PG  G PG  G  G PG
Sbjct:   231 GEPGVSGPMGPRGPPGPAGKPGDDGEAGKPG 261

 Score = 85 (35.0 bits), Expect = 2.0e-293, Sum P(7) = 2.0e-293
 Identities = 17/32 (53%), Positives = 20/32 (62%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             GAAG  GP G  G+ G  GP G  GKDG +G+
Sbjct:   900 GAAGRVGPPGANGNPGPAGPPGPAGKDGPKGV 931

 Score = 85 (35.0 bits), Expect = 6.4e-272, Sum P(8) = 6.4e-272
 Identities = 17/33 (51%), Positives = 21/33 (63%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             +G +G  GP GA G  G PG PG +G RG PG+
Sbjct:   569 AGPQGKVGPSGAPGEDGRPGPPGPQGARGQPGV 601

 Score = 85 (35.0 bits), Expect = 6.4e-260, Sum P(7) = 6.4e-260
 Identities = 16/33 (48%), Positives = 20/33 (60%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +RG  G+ G +G+RG  G  GP G PGK G  G
Sbjct:   979 QRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPG 1011

 Score = 85 (35.0 bits), Expect = 7.6e-240, Sum P(5) = 7.6e-240
 Identities = 17/31 (54%), Positives = 18/31 (58%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GE G PGP G  G PG  G PG KG +G  G
Sbjct:   825 GETGPPGPAGFAGPPGADGQPGAKGDQGEAG 855

 Score = 84 (34.6 bits), Expect = 1.2e-310, Sum P(8) = 1.2e-310
 Identities = 15/17 (88%), Positives = 16/17 (94%)

Query:   652 KSGDQGVPGEAGAPGLV 668
             K GDQG+PGEAGAPGLV
Sbjct:   679 KQGDQGIPGEAGAPGLV 695

 Score = 84 (34.6 bits), Expect = 5.4e-299, Sum P(8) = 5.4e-299
 Identities = 19/37 (51%), Positives = 21/37 (56%)

Query:   237 GERGLPGPQGARGFPGTPGL------PGVKGHRGFPG 267
             G  GLPG +G RG+PG  G       PGVKG  G PG
Sbjct:   279 GTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPG 315

 Score = 84 (34.6 bits), Expect = 8.2e-260, Sum P(7) = 8.2e-260
 Identities = 16/32 (50%), Positives = 19/32 (59%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +G  G  GP G  GD G +GP GAPG+ G  G
Sbjct:   929 KGVRGDSGPPGRAGDPGLQGPAGAPGEKGEPG 960

 Score = 84 (34.6 bits), Expect = 5.3e-239, Sum P(5) = 5.3e-239
 Identities = 17/31 (54%), Positives = 17/31 (54%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G RG  GP GA GFPG  G  G  G  G PG
Sbjct:   885 GARGAQGPPGATGFPGAAGRVGPPGANGNPG 915

 Score = 84 (34.6 bits), Expect = 7.4e-231, Sum P(7) = 7.4e-231
 Identities = 25/76 (32%), Positives = 26/76 (34%)

Query:   478 PPGERGAPGNRGF---PGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARG 534
             PPG +G  G RG    PGQ G  G                         PG  G PG  G
Sbjct:   970 PPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTG 1029

Query:   535 LTGRPGDAGPQGKLGP 550
               G PG  G  G  GP
Sbjct:  1030 PAGEPGREGSPGADGP 1045

 Score = 84 (34.6 bits), Expect = 1.8e-221, Sum P(6) = 1.8e-221
 Identities = 25/73 (34%), Positives = 28/73 (38%)

Query:   478 PPGERGAPGN-R---GFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGAR 533
             P G++G PG+ R   G  G  G  GP                       R GEPG PG  
Sbjct:   101 PKGQKGEPGDIRDIIGPRGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGTPGNP 160

Query:   534 GLTGRPGDAGPQG 546
             G  G PG  GP G
Sbjct:   161 GPAGPPGPPGPPG 173

 Score = 83 (34.3 bits), Expect = 1.5e-274, Sum P(8) = 1.5e-274
 Identities = 17/35 (48%), Positives = 20/35 (57%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPGLD 269
             + G+RG  G  G  G  G PG  G  G+RGFPG D
Sbjct:   487 EEGKRGARGEPGGAGPIGPPGERGAPGNRGFPGQD 521

 Score = 82 (33.9 bits), Expect = 1.3e-284, Sum P(8) = 1.3e-284
 Identities = 24/72 (33%), Positives = 26/72 (36%)

Query:   480 GERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRP 539
             G  GA G RG  GQ G AGP                         G  G  GA+G  G P
Sbjct:   336 GPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGSRGEP 395

Query:   540 GDAGPQGKLGPS 551
             G+ G  G  G S
Sbjct:   396 GNPGSPGPAGAS 407

 Score = 82 (33.9 bits), Expect = 9.2e-259, Sum P(7) = 9.2e-259
 Identities = 16/32 (50%), Positives = 20/32 (62%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G AG  G +GDRG+ G +GP G  G  G RG+
Sbjct:  1077 GPAGPTGKQGDRGEAGAQGPMGPSGPAGARGI 1108

 Score = 82 (33.9 bits), Expect = 1.6e-239, Sum P(5) = 1.6e-239
 Identities = 16/33 (48%), Positives = 19/33 (57%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             + G+ G PGPQG  G PG  G  GV G +G  G
Sbjct:   856 QKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARG 888

 Score = 82 (33.9 bits), Expect = 3.1e-214, Sum P(6) = 3.1e-214
 Identities = 16/32 (50%), Positives = 18/32 (56%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             GE+G PG  G  G  G PG  G+ G RG  GL
Sbjct:   954 GEKGEPGDDGPSGLDGPPGPQGLAGQRGIVGL 985

 Score = 82 (33.9 bits), Expect = 3.5e-212, Sum P(5) = 3.5e-212
 Identities = 22/72 (30%), Positives = 26/72 (36%)

Query:   479 PGERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGR 538
             PG  G  G++G  G  G +GP+                       PG  G  G  G  G 
Sbjct:  1142 PGPPGPSGDQGASGPAGPSGPRGPPGPVGPSGKDGSNGIPGPIGPPGPRGRSGETGPVGP 1201

Query:   539 PGDAGPQGKLGP 550
             PG  GP G  GP
Sbjct:  1202 PGSPGPPGPPGP 1213

 Score = 81 (33.6 bits), Expect = 1.1e-298, Sum P(8) = 1.1e-298
 Identities = 17/33 (51%), Positives = 17/33 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGLD 269
             GE G PGP G RG PG  G  G  G  G  G D
Sbjct:   315 GENGSPGPMGPRGLPGERGRTGPAGAAGARGND 347

 Score = 81 (33.6 bits), Expect = 1.1e-298, Sum P(8) = 1.1e-298
 Identities = 18/34 (52%), Positives = 19/34 (55%)

Query:   237 GERGLPGPQGARGFPGTPG---LPGVKGHRGFPG 267
             G  G PG  G  G PG  G   LPG +G RGFPG
Sbjct:   246 GPAGKPGDDGEAGKPGKSGERGLPGPQGARGFPG 279

 Score = 81 (33.6 bits), Expect = 1.7e-259, Sum P(7) = 1.7e-259
 Identities = 16/31 (51%), Positives = 18/31 (58%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  G KGDRG+ G  G  GAPG  G+ G
Sbjct:  1047 GRDGAAGVKGDRGETGALGAPGAPGPPGSPG 1077

 Score = 81 (33.6 bits), Expect = 1.7e-259, Sum P(7) = 1.7e-259
 Identities = 17/33 (51%), Positives = 19/33 (57%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +RG  G  GP G  G  GE G EG+PG DG  G
Sbjct:  1015 DRGPPGPVGPPGLTGPAGEPGREGSPGADGPPG 1047

 Score = 81 (33.6 bits), Expect = 2.9e-248, Sum P(6) = 2.9e-248
 Identities = 15/32 (46%), Positives = 21/32 (65%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             RG  G+ G KG+ G  G KG  G+PG++G+ G
Sbjct:   290 RGYPGLDGAKGEAGAPGVKGESGSPGENGSPG 321

 Score = 81 (33.6 bits), Expect = 3.9e-214, Sum P(6) = 3.9e-214
 Identities = 16/31 (51%), Positives = 19/31 (61%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G++G PG  G RG PG  G PG+ G  G PG
Sbjct:  1005 GKQGAPGASGDRGPPGPVGPPGLTGPAGEPG 1035

 Score = 80 (33.2 bits), Expect = 5.9e-292, Sum P(7) = 5.9e-292
 Identities = 16/34 (47%), Positives = 20/34 (58%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             ERG  G  GP G +G  G  GP G  GK G++G+
Sbjct:   652 ERGEQGAPGPSGFQGLPGPPGPPGEGGKQGDQGI 685

 Score = 80 (33.2 bits), Expect = 3.1e-274, Sum P(8) = 3.1e-274
 Identities = 17/31 (54%), Positives = 19/31 (61%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G+ GL GP+GA G  G  GL G KG  G PG
Sbjct:   519 GQDGLAGPKGAPGERGPSGLTGPKGANGDPG 549

 Score = 80 (33.2 bits), Expect = 4.3e-255, Sum P(7) = 4.3e-255
 Identities = 17/31 (54%), Positives = 18/31 (58%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G RG PGPQG  G  G  G  G KG +G PG
Sbjct:   116 GPRGPPGPQGPAGEQGPRGDRGDKGEKGAPG 146

 Score = 80 (33.2 bits), Expect = 3.8e-194, Sum P(4) = 3.8e-194
 Identities = 16/33 (48%), Positives = 19/33 (57%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             + GERGL G +G  G  G PG PG  G +G  G
Sbjct:  1123 EQGERGLKGHRGFTGLQGLPGPPGPSGDQGASG 1155

 Score = 79 (32.9 bits), Expect = 3.8e-300, Sum P(8) = 3.8e-300
 Identities = 16/31 (51%), Positives = 19/31 (61%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G+ GP+G  G  G  GP+GA G DG  G
Sbjct:   711 GAQGLQGPRGLPGTPGTDGPKGAAGPDGPPG 741

 Score = 79 (32.9 bits), Expect = 4.7e-267, Sum P(7) = 4.7e-267
 Identities = 15/33 (45%), Positives = 18/33 (54%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             ++G  G PGP G  G  G  G PG  G +G PG
Sbjct:   637 ETGAAGPPGPSGPAGERGEQGAPGPSGFQGLPG 669

 Score = 79 (32.9 bits), Expect = 1.6e-249, Sum P(6) = 1.6e-249
 Identities = 15/32 (46%), Positives = 18/32 (56%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             G +G  GP G  G  G PGL G+ G RG  G+
Sbjct:   729 GPKGAAGPDGPPGAQGPPGLQGMPGERGAAGI 760

 Score = 79 (32.9 bits), Expect = 2.0e-245, Sum P(6) = 2.0e-245
 Identities = 16/32 (50%), Positives = 17/32 (53%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G  G  GP G  G  G+ G  G PGK G RGL
Sbjct:   237 GPMGPRGPPGPAGKPGDDGEAGKPGKSGERGL 268

 Score = 78 (32.5 bits), Expect = 1.1e-292, Sum P(7) = 1.1e-292
 Identities = 17/31 (54%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G AG  GPKG RGD G  G  G PG  G  G
Sbjct:   921 GPAGKDGPKGVRGDSGPPGRAGDPGLQGPAG 951

 Score = 78 (32.5 bits), Expect = 5.1e-274, Sum P(8) = 5.1e-274
 Identities = 17/35 (48%), Positives = 19/35 (54%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPGLD 269
             + GE GLPG +G  G PG  G  G  G  G PG D
Sbjct:   550 RPGEPGLPGARGLTGRPGDAGPQGKVGPSGAPGED 584

 Score = 78 (32.5 bits), Expect = 3.5e-259, Sum P(7) = 3.5e-259
 Identities = 14/31 (45%), Positives = 20/31 (64%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G +G+ GP G +G  G++G  G PG+ G RG
Sbjct:   963 GPSGLDGPPGPQGLAGQRGIVGLPGQRGERG 993

 Score = 78 (32.5 bits), Expect = 3.5e-259, Sum P(7) = 3.5e-259
 Identities = 14/32 (43%), Positives = 19/32 (59%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G  G+ GP G+ G  G  G +G PG+DG  G+
Sbjct:  1023 GPPGLTGPAGEPGREGSPGADGPPGRDGAAGV 1054

 Score = 78 (32.5 bits), Expect = 1.8e-248, Sum P(6) = 1.8e-248
 Identities = 16/34 (47%), Positives = 21/34 (61%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             ++GA+G  GP G RG  G  GP G   KDG+ G+
Sbjct:  1150 DQGASGPAGPSGPRGPPGPVGPSG---KDGSNGI 1180

 Score = 78 (32.5 bits), Expect = 2.3e-238, Sum P(5) = 2.3e-238
 Identities = 17/34 (50%), Positives = 19/34 (55%)

Query:   237 GERGLPGPQGARGF---PGTPGLPGVKGHRGFPG 267
             G  G+ GP+GARG    PG  G PG  G  G PG
Sbjct:   876 GPTGVTGPKGARGAQGPPGATGFPGAAGRVGPPG 909

 Score = 77 (32.2 bits), Expect = 3.0e-298, Sum P(8) = 3.0e-298
 Identities = 15/29 (51%), Positives = 18/29 (62%)

Query:   239 RGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +G  GP G RG PG  G PG +G +G PG
Sbjct:   200 QGPMGPMGPRGPPGPAGAPGPQGFQGNPG 228

 Score = 77 (32.2 bits), Expect = 1.4e-292, Sum P(7) = 1.4e-292
 Identities = 15/33 (45%), Positives = 19/33 (57%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             ++G AG  GP+G  G  G +GP G  G  G RG
Sbjct:   856 QKGDAGAPGPQGPSGAPGPQGPTGVTGPKGARG 888

 Score = 77 (32.2 bits), Expect = 1.3e-257, Sum P(6) = 1.3e-257
 Identities = 16/33 (48%), Positives = 18/33 (54%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             ERG  G  G  G RG+ G+ GP G PG  G  G
Sbjct:   331 ERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAG 363

 Score = 77 (32.2 bits), Expect = 2.5e-249, Sum P(6) = 2.5e-249
 Identities = 15/31 (48%), Positives = 18/31 (58%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G  GP GA+G PG  G+PG +G  G  G
Sbjct:   732 GAAGPDGPPGAQGPPGLQGMPGERGAAGIAG 762

 Score = 77 (32.2 bits), Expect = 2.3e-194, Sum P(4) = 2.3e-194
 Identities = 17/33 (51%), Positives = 20/33 (60%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +SGE+G  G +G RGF G  GLPG  G  G  G
Sbjct:  1120 ESGEQGERGLKGHRGFTGLQGLPGPPGPSGDQG 1152

 Score = 76 (31.8 bits), Expect = 9.8e-269, Sum P(7) = 9.8e-269
 Identities = 20/44 (45%), Positives = 24/44 (54%)

Query:   727 ERGAAGIGGPKGDRGDVGEKG---------PEGAPGKDGNRGLT 761
             E G AG  GP G+RG  G +G         P+GAPG+ G  GLT
Sbjct:   496 EPGGAGPIGPPGERGAPGNRGFPGQDGLAGPKGAPGERGPSGLT 539

 Score = 76 (31.8 bits), Expect = 5.7e-259, Sum P(7) = 5.7e-259
 Identities = 15/31 (48%), Positives = 19/31 (61%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA+G  GP G  G  G  GP G PG++G+ G
Sbjct:  1011 GASGDRGPPGPVGPPGLTGPAGEPGREGSPG 1041

 Score = 76 (31.8 bits), Expect = 1.6e-257, Sum P(6) = 1.6e-257
 Identities = 15/31 (48%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  G KG+ G  G +GPEGA G  G  G
Sbjct:   366 GFPGAPGAKGEAGPTGARGPEGAQGSRGEPG 396

 Score = 76 (31.8 bits), Expect = 1.6e-257, Sum P(6) = 1.6e-257
 Identities = 16/33 (48%), Positives = 19/33 (57%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E G+ G  GP+G  G+ G  GP GA G  GN G
Sbjct:   316 ENGSPGPMGPRGLPGERGRTGPAGAAGARGNDG 348

 Score = 76 (31.8 bits), Expect = 1.6e-257, Sum P(6) = 1.6e-257
 Identities = 16/35 (45%), Positives = 18/35 (51%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             E GA G+ G  G  G+ G  GP G  G  G RG T
Sbjct:   301 EAGAPGVKGESGSPGENGSPGPMGPRGLPGERGRT 335

 Score = 76 (31.8 bits), Expect = 4.6e-244, Sum P(6) = 4.6e-244
 Identities = 15/32 (46%), Positives = 18/32 (56%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +GE+G  GP G  G  G  G PG +G  G PG
Sbjct:   800 NGEKGEVGPPGPSGSTGARGAPGERGETGPPG 831

 Score = 76 (31.8 bits), Expect = 6.4e-205, Sum P(5) = 6.4e-205
 Identities = 16/32 (50%), Positives = 18/32 (56%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             SG+RG PGP G  G  G  G PG +G  G  G
Sbjct:  1013 SGDRGPPGPVGPPGLTGPAGEPGREGSPGADG 1044

 Score = 75 (31.5 bits), Expect = 1.2e-310, Sum P(8) = 1.2e-310
 Identities = 17/38 (44%), Positives = 19/38 (50%)

Query:   823 EQGESGQKGDXXXXXXXXXXXXXXXXXXNGVTGPKGAR 860
             +QGE+GQKGD                   GVTGPKGAR
Sbjct:   850 DQGEAGQKGDAGAPGPQGPSGAPGPQGPTGVTGPKGAR 887

 Score = 75 (31.5 bits), Expect = 4.8e-298, Sum P(8) = 4.8e-298
 Identities = 17/31 (54%), Positives = 17/31 (54%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G RG PGPQGA G  G  G  G  G  GF G
Sbjct:   435 GPRGPPGPQGATGPLGPKGQAGEPGIAGFKG 465

 Score = 75 (31.5 bits), Expect = 2.0e-291, Sum P(7) = 2.0e-291
 Identities = 15/32 (46%), Positives = 18/32 (56%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G  G  GPKG  G+ G+ G +G  G  G RGL
Sbjct:   600 GVMGFPGPKGANGEPGKAGEKGLAGAPGLRGL 631

 Score = 75 (31.5 bits), Expect = 1.0e-273, Sum P(8) = 1.0e-273
 Identities = 15/31 (48%), Positives = 18/31 (58%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G +G  GP G +G PG  G  G +G RG PG
Sbjct:   468 GPKGETGPAGPQGAPGPAGEEGKRGARGEPG 498

 Score = 75 (31.5 bits), Expect = 1.2e-266, Sum P(7) = 1.2e-266
 Identities = 16/33 (48%), Positives = 18/33 (54%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             K+GE+GL G  G RG PG  G  G  G  G  G
Sbjct:   616 KAGEKGLAGAPGLRGLPGKDGETGAAGPPGPSG 648

 Score = 75 (31.5 bits), Expect = 4.1e-264, Sum P(7) = 4.1e-264
 Identities = 22/74 (29%), Positives = 27/74 (36%)

Query:   478 PPGERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTG 537
             P G+RG  G +G  G  G  G +                       PG  G  GARG  G
Sbjct:   763 PKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKGEVGPPGPSGSTGARGAPG 822

Query:   538 RPGDAGPQGKLGPS 551
               G+ GP G   P+
Sbjct:   823 ERGETGPPG---PA 833

 Score = 75 (31.5 bits), Expect = 2.0e-257, Sum P(6) = 2.0e-257
 Identities = 15/31 (48%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G  GP G RG  G +G  G PG  G+ G
Sbjct:   372 GAKGEAGPTGARGPEGAQGSRGEPGNPGSPG 402

 Score = 75 (31.5 bits), Expect = 5.2e-245, Sum P(6) = 5.2e-245
 Identities = 16/33 (48%), Positives = 17/33 (51%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E G  G+ GP G RG     GP G PG DG  G
Sbjct:   229 EPGEPGVSGPMGPRGP---PGPAGKPGDDGEAG 258

 Score = 75 (31.5 bits), Expect = 6.5e-230, Sum P(7) = 6.5e-230
 Identities = 22/67 (32%), Positives = 23/67 (34%)

Query:   483 GAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRPGDA 542
             G PG RG  G  GL GP                        PG  G  G  G  G PG  
Sbjct:   984 GLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGAD 1043

Query:   543 GPQGKLG 549
             GP G+ G
Sbjct:  1044 GPPGRDG 1050

 Score = 75 (31.5 bits), Expect = 4.4e-204, Sum P(5) = 4.4e-204
 Identities = 17/32 (53%), Positives = 18/32 (56%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +GE G  G  GA G PG  G  GVKG RG  G
Sbjct:  1031 AGEPGREGSPGADGPPGRDGAAGVKGDRGETG 1062

 Score = 75 (31.5 bits), Expect = 1.1e-194, Sum P(4) = 1.1e-194
 Identities = 16/35 (45%), Positives = 19/35 (54%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             E+GA G  G  G+ G  G  GP G PG  G  GL+
Sbjct:   141 EKGAPGPRGRDGEPGTPGNPGPAGPPGPPGPPGLS 175

 Score = 75 (31.5 bits), Expect = 1.3e-193, Sum P(4) = 1.3e-193
 Identities = 16/32 (50%), Positives = 18/32 (56%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +G +GLPGP G  G  G  G  G  G RG PG
Sbjct:  1136 TGLQGLPGPPGPSGDQGASGPAGPSGPRGPPG 1167

 Score = 75 (31.5 bits), Expect = 3.2e-187, Sum P(3) = 3.2e-187
 Identities = 17/33 (51%), Positives = 19/33 (57%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGLD 269
             G RG  G  G  G PG+PG PG  G  G PG+D
Sbjct:  1188 GPRGRSGETGPVGPPGSPGPPGPPGPPG-PGID 1219

 Score = 74 (31.1 bits), Expect = 1.3e-299, Sum P(8) = 1.3e-299
 Identities = 16/32 (50%), Positives = 17/32 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             RG  G  GP G  G  GEKG  G PG  G+ G
Sbjct:   785 RGLTGPIGPPGPAGANGEKGEVGPPGPSGSTG 816

 Score = 74 (31.1 bits), Expect = 2.5e-291, Sum P(7) = 2.5e-291
 Identities = 15/32 (46%), Positives = 18/32 (56%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +GA G  G  G++G  G  G  G PGKDG  G
Sbjct:   608 KGANGEPGKAGEKGLAGAPGLRGLPGKDGETG 639

 Score = 74 (31.1 bits), Expect = 1.3e-273, Sum P(8) = 1.3e-273
 Identities = 18/31 (58%), Positives = 18/31 (58%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GERG PG    RGFPG  GL G KG  G  G
Sbjct:   507 GERGAPGN---RGFPGQDGLAGPKGAPGERG 534

 Score = 74 (31.1 bits), Expect = 1.3e-255, Sum P(6) = 1.3e-255
 Identities = 18/37 (48%), Positives = 20/37 (54%)

Query:   237 GERGLPG------PQGARGFPGTPGLPGVKGHRGFPG 267
             G RGLPG      P+GA G  G PG  G  G +G PG
Sbjct:   717 GPRGLPGTPGTDGPKGAAGPDGPPGAQGPPGLQGMPG 753

 Score = 74 (31.1 bits), Expect = 1.2e-201, Sum P(5) = 1.2e-201
 Identities = 16/31 (51%), Positives = 17/31 (54%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G+RG  G  GA G PG PG PG  G  G  G
Sbjct:  1056 GDRGETGALGAPGAPGPPGSPGPAGPTGKQG 1086

 Score = 73 (30.8 bits), Expect = 7.8e-298, Sum P(8) = 7.8e-298
 Identities = 15/28 (53%), Positives = 16/28 (57%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRG 264
             G  G PG  GA GFPG  G PG +G  G
Sbjct:   420 GSAGAPGIAGAPGFPGPRGPPGPQGATG 447

 Score = 73 (30.8 bits), Expect = 7.8e-298, Sum P(8) = 7.8e-298
 Identities = 16/34 (47%), Positives = 18/34 (52%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKG---HRGFPG 267
             G RG PG  GA+G  G PG+ G  G     G PG
Sbjct:   288 GHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPG 321

 Score = 73 (30.8 bits), Expect = 3.7e-292, Sum P(7) = 3.7e-292
 Identities = 15/32 (46%), Positives = 17/32 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +G  G+ GPKG RG  G  G  G PG  G  G
Sbjct:   875 QGPTGVTGPKGARGAQGPPGATGFPGAAGRVG 906

 Score = 73 (30.8 bits), Expect = 3.2e-291, Sum P(7) = 3.2e-291
 Identities = 14/32 (43%), Positives = 20/32 (62%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G  G+ GP G  G+ G++G +G PG+ G  GL
Sbjct:   663 GFQGLPGPPGPPGEGGKQGDQGIPGEAGAPGL 694

 Score = 73 (30.8 bits), Expect = 2.0e-268, Sum P(7) = 2.0e-268
 Identities = 14/32 (43%), Positives = 18/32 (56%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +G  G  GP+G  G  GE+G  GA G+ G  G
Sbjct:   470 KGETGPAGPQGAPGPAGEEGKRGARGEPGGAG 501

 Score = 73 (30.8 bits), Expect = 2.0e-268, Sum P(7) = 2.0e-268
 Identities = 17/34 (50%), Positives = 20/34 (58%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGK---DGNRG 759
             G AG  G +G RG+ G  GP G PG+    GNRG
Sbjct:   483 GPAGEEGKRGARGEPGGAGPIGPPGERGAPGNRG 516

 Score = 73 (30.8 bits), Expect = 2.0e-268, Sum P(7) = 2.0e-268
 Identities = 18/38 (47%), Positives = 22/38 (57%)

Query:   729 GAAGIGGPKG---DRGDVGEKGPEGA---PGKDGNRGL 760
             G  G+ GPKG   +RG  G  GP+GA   PG+ G  GL
Sbjct:   519 GQDGLAGPKGAPGERGPSGLTGPKGANGDPGRPGEPGL 556

 Score = 73 (30.8 bits), Expect = 3.7e-267, Sum P(7) = 3.7e-267
 Identities = 14/33 (42%), Positives = 18/33 (54%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             RG  G  G +G+ G+ G  GP GA G  G  G+
Sbjct:   383 RGPEGAQGSRGEPGNPGSPGPAGASGNPGTDGI 415

 Score = 73 (30.8 bits), Expect = 2.0e-266, Sum P(7) = 2.0e-266
 Identities = 16/31 (51%), Positives = 16/31 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G RGLPG  G  G  G PG  G  G RG  G
Sbjct:   627 GLRGLPGKDGETGAAGPPGPSGPAGERGEQG 657

 Score = 73 (30.8 bits), Expect = 8.4e-264, Sum P(7) = 8.4e-264
 Identities = 21/70 (30%), Positives = 24/70 (34%)

Query:   480 GERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGRP 539
             G  G PG  G  G+ G  GP                        PG  G  G  G  G+P
Sbjct:   789 GPIGPPGPAGANGEKGEVGPPGPSGSTGARGAPGERGETGP---PGPAGFAGPPGADGQP 845

Query:   540 GDAGPQGKLG 549
             G  G QG+ G
Sbjct:   846 GAKGDQGEAG 855

 Score = 73 (30.8 bits), Expect = 1.2e-258, Sum P(7) = 1.2e-258
 Identities = 15/32 (46%), Positives = 18/32 (56%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +G AG  G KG+ GD G  G +G PG  G  G
Sbjct:   947 QGPAGAPGEKGEPGDDGPSGLDGPPGPQGLAG 978

 Score = 73 (30.8 bits), Expect = 3.3e-257, Sum P(6) = 3.3e-257
 Identities = 15/33 (45%), Positives = 18/33 (54%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E G  G  GP+G +G  GE G  G+PG  G  G
Sbjct:   376 EAGPTGARGPEGAQGSRGEPGNPGSPGPAGASG 408

 Score = 73 (30.8 bits), Expect = 2.4e-254, Sum P(7) = 2.4e-254
 Identities = 15/31 (48%), Positives = 17/31 (54%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G  GP+G RG  G  G PG +G  G PG
Sbjct:   125 GPAGEQGPRGDRGDKGEKGAPGPRGRDGEPG 155

 Score = 73 (30.8 bits), Expect = 5.9e-248, Sum P(6) = 5.9e-248
 Identities = 16/31 (51%), Positives = 16/31 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GP G RG  GE GP G PG  G  G
Sbjct:  1179 GIPGPIGPPGPRGRSGETGPVGPPGSPGPPG 1209

 Score = 73 (30.8 bits), Expect = 9.5e-244, Sum P(6) = 9.5e-244
 Identities = 18/36 (50%), Positives = 19/36 (52%)

Query:   235 KSGERGLPGPQG---ARGFPGTPGLPGVKGHRGFPG 267
             + GE G PGP G   ARG PG  G  G  G  GF G
Sbjct:   802 EKGEVGPPGPSGSTGARGAPGERGETGPPGPAGFAG 837

 Score = 73 (30.8 bits), Expect = 2.5e-220, Sum P(6) = 2.5e-220
 Identities = 21/72 (29%), Positives = 26/72 (36%)

Query:   480 GERGAPGNRGFPGQ-DGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTGR 538
             G+ G  G +G PG    + GP+                        G PG  G  G  G 
Sbjct:    97 GKLGPKGQKGEPGDIRDIIGPRGPPGPQGPAGEQGPRGDRGDKGEKGAPGPRGRDGEPGT 156

Query:   539 PGDAGPQGKLGP 550
             PG+ GP G  GP
Sbjct:   157 PGNPGPAGPPGP 168

 Score = 73 (30.8 bits), Expect = 3.5e-215, Sum P(6) = 3.5e-215
 Identities = 16/33 (48%), Positives = 17/33 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGLD 269
             G RG  GP G  G PG  G  G  G +G PG D
Sbjct:   930 GVRGDSGPPGRAGDPGLQGPAGAPGEKGEPGDD 962

 Score = 73 (30.8 bits), Expect = 2.7e-213, Sum P(6) = 2.7e-213
 Identities = 16/33 (48%), Positives = 19/33 (57%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             ++G+ GL GP GA G  G PG  G  G  G PG
Sbjct:   940 RAGDPGLQGPAGAPGEKGEPGDDGPSGLDGPPG 972

 Score = 72 (30.4 bits), Expect = 2.1e-299, Sum P(8) = 2.1e-299
 Identities = 16/33 (48%), Positives = 17/33 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             G AG  G KG+ G  G  G  GA G  G RG T
Sbjct:   795 GPAGANGEKGEVGPPGPSGSTGARGAPGERGET 827

 Score = 72 (30.4 bits), Expect = 9.9e-298, Sum P(8) = 9.9e-298
 Identities = 15/33 (45%), Positives = 18/33 (54%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             +G  G PGP+G  G  G  G  G KG  G PG+
Sbjct:   428 AGAPGFPGPRGPPGPQGATGPLGPKGQAGEPGI 460

 Score = 72 (30.4 bits), Expect = 4.7e-292, Sum P(7) = 4.7e-292
 Identities = 15/32 (46%), Positives = 18/32 (56%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G AG  GP G  G  G +G  G PG+ G+ GL
Sbjct:   915 GPAGPPGPAGKDGPKGVRGDSGPPGRAGDPGL 946

 Score = 72 (30.4 bits), Expect = 4.1e-291, Sum P(7) = 4.1e-291
 Identities = 19/40 (47%), Positives = 23/40 (57%)

Query:   727 ERGAAGIGGPKGDRGD---VGEKGPEGA---PGKDGNRGL 760
             E G  G  GP+G RG    +G  GP+GA   PGK G +GL
Sbjct:   583 EDGRPGPPGPQGARGQPGVMGFPGPKGANGEPGKAGEKGL 622

 Score = 72 (30.4 bits), Expect = 1.5e-258, Sum P(7) = 1.5e-258
 Identities = 15/33 (45%), Positives = 17/33 (51%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +RG  G  G  G  G  G  GP G  GK G+RG
Sbjct:  1057 DRGETGALGAPGAPGPPGSPGPAGPTGKQGDRG 1089

 Score = 72 (30.4 bits), Expect = 7.5e-248, Sum P(6) = 7.5e-248
 Identities = 14/31 (45%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GP+G  G+ G  GP G+PG  G  G
Sbjct:  1182 GPIGPPGPRGRSGETGPVGPPGSPGPPGPPG 1212

 Score = 72 (30.4 bits), Expect = 1.1e-238, Sum P(5) = 1.1e-238
 Identities = 15/32 (46%), Positives = 17/32 (53%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +G RG PG +G  G PG  G  G  G  G PG
Sbjct:   815 TGARGAPGERGETGPPGPAGFAGPPGADGQPG 846

 Score = 72 (30.4 bits), Expect = 1.3e-230, Sum P(4) = 1.3e-230
 Identities = 16/34 (47%), Positives = 19/34 (55%)

Query:   237 GERGLPGPQGARGFPGTPGL---PGVKGHRGFPG 267
             G  G  GP+G RG  G PG    PG++G  G PG
Sbjct:   921 GPAGKDGPKGVRGDSGPPGRAGDPGLQGPAGAPG 954

 Score = 72 (30.4 bits), Expect = 4.0e-211, Sum P(5) = 4.0e-211
 Identities = 22/69 (31%), Positives = 24/69 (34%)

Query:   478 PPGERGAPGNRGFPGQDGLAGPKXXXXXXXXXXXXXXXXXXXXXXRPGEPGLPGARGLTG 537
             P G++GA G  G  G  G  GP                       R GE G  G  G  G
Sbjct:  1147 PSGDQGASGPAGPSGPRGPPGPVGPSGKDGSNGIPGPIGPPGPRGRSGETGPVGPPGSPG 1206

Query:   538 RPGDAGPQG 546
              PG  GP G
Sbjct:  1207 PPGPPGPPG 1215

 Score = 72 (30.4 bits), Expect = 1.3e-150, Sum P(3) = 1.3e-150
 Identities = 17/36 (47%), Positives = 18/36 (50%)

Query:    90 GPRGPLGPQGPSGEQXXXXXXXXXXXXXXTPGPRGR 125
             GPRGP GP GPSG+                PGPRGR
Sbjct:  1161 GPRGPPGPVGPSGKDGSNGIPGPIG----PPGPRGR 1192

 Score = 71 (30.1 bits), Expect = 2.6e-299, Sum P(8) = 2.6e-299
 Identities = 15/34 (44%), Positives = 18/34 (52%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEG---APGKDGNRG 759
             G+ G  G  G+RG+ G  GP G    PG DG  G
Sbjct:   813 GSTGARGAPGERGETGPPGPAGFAGPPGADGQPG 846

 Score = 71 (30.1 bits), Expect = 2.8e-273, Sum P(8) = 2.8e-273
 Identities = 15/32 (46%), Positives = 19/32 (59%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +G  G PG +GA G  G PG  G+ G +G PG
Sbjct:   500 AGPIGPPGERGAPGNRGFPGQDGLAGPKGAPG 531

 Score = 71 (30.1 bits), Expect = 3.2e-266, Sum P(7) = 3.2e-266
 Identities = 15/32 (46%), Positives = 17/32 (53%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +GE G  G +G  G PG  GLPG  G  G  G
Sbjct:   611 NGEPGKAGEKGLAGAPGLRGLPGKDGETGAAG 642

 Score = 71 (30.1 bits), Expect = 1.9e-258, Sum P(7) = 1.9e-258
 Identities = 17/38 (44%), Positives = 20/38 (52%)

Query:   727 ERGAAGIGGPKGD---RGDVGEKGPEGAPGKDGNRGLT 761
             ERG  G+ GP G+   +G  G  G  G PG  G  GLT
Sbjct:   991 ERGFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLT 1028

 Score = 71 (30.1 bits), Expect = 2.1e-253, Sum P(7) = 2.1e-253
 Identities = 14/33 (42%), Positives = 18/33 (54%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +RG AG  GP G  G  G +G  G  G  G++G
Sbjct:  1087 DRGEAGAQGPMGPSGPAGARGIAGPQGPRGDKG 1119

 Score = 71 (30.1 bits), Expect = 2.3e-238, Sum P(5) = 2.3e-238
 Identities = 16/34 (47%), Positives = 17/34 (50%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGH---RGFPG 267
             G  G PGPQG  G  G  G  G +G     GFPG
Sbjct:   867 GPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPG 900

 Score = 71 (30.1 bits), Expect = 2.5e-237, Sum P(5) = 2.5e-237
 Identities = 15/31 (48%), Positives = 18/31 (58%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G AG  GP+G +G+ GE G  G  G  G RG
Sbjct:   213 GPAGAPGPQGFQGNPGEPGEPGVSGPMGPRG 243

 Score = 71 (30.1 bits), Expect = 8.6e-187, Sum P(3) = 8.6e-187
 Identities = 14/24 (58%), Positives = 16/24 (66%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPG 258
             +SGE G  GP G+ G PG PG PG
Sbjct:  1192 RSGETGPVGPPGSPGPPGPPGPPG 1215

 Score = 70 (29.7 bits), Expect = 7.6e-292, Sum P(7) = 7.6e-292
 Identities = 15/32 (46%), Positives = 17/32 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +GA G  GP G  G  G  G  G PG +GN G
Sbjct:   884 KGARGAQGPPGATGFPGAAGRVGPPGANGNPG 915

 Score = 70 (29.7 bits), Expect = 6.7e-291, Sum P(7) = 6.7e-291
 Identities = 15/31 (48%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G GG +GD+G  GE G  G  G  G RG
Sbjct:   672 GPPGEGGKQGDQGIPGEAGAPGLVGPRGERG 702

 Score = 70 (29.7 bits), Expect = 6.7e-291, Sum P(7) = 6.7e-291
 Identities = 17/36 (47%), Positives = 19/36 (52%)

Query:   727 ERGAAGI---GGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E GAAG     GP G+RG+ G  GP G  G  G  G
Sbjct:   637 ETGAAGPPGPSGPAGERGEQGAPGPSGFQGLPGPPG 672

 Score = 70 (29.7 bits), Expect = 2.4e-258, Sum P(7) = 2.4e-258
 Identities = 13/32 (40%), Positives = 18/32 (56%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G  G  G  G++G+ G+ GP G  G  G +GL
Sbjct:   945 GLQGPAGAPGEKGEPGDDGPSGLDGPPGPQGL 976

 Score = 70 (29.7 bits), Expect = 4.3e-193, Sum P(4) = 4.3e-193
 Identities = 15/31 (48%), Positives = 15/31 (48%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G  GP G RG PG  G  G  G  G PG
Sbjct:  1152 GASGPAGPSGPRGPPGPVGPSGKDGSNGIPG 1182

 Score = 70 (29.7 bits), Expect = 3.8e-192, Sum P(4) = 3.8e-192
 Identities = 15/29 (51%), Positives = 17/29 (58%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRG 264
             SG RG PGP G  G  G+ G+PG  G  G
Sbjct:  1160 SGPRGPPGPVGPSGKDGSNGIPGPIGPPG 1188

 Score = 69 (29.3 bits), Expect = 4.3e-299, Sum P(8) = 4.3e-299
 Identities = 14/33 (42%), Positives = 17/33 (51%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             +G  G+ G  G  G  G  GP+G PG  G  GL
Sbjct:   716 QGPRGLPGTPGTDGPKGAAGPDGPPGAQGPPGL 748

 Score = 69 (29.3 bits), Expect = 2.0e-297, Sum P(8) = 2.0e-297
 Identities = 15/28 (53%), Positives = 15/28 (53%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRG 264
             GERG  GP GA G  G  G PG  G  G
Sbjct:   330 GERGRTGPAGAAGARGNDGQPGPAGPPG 357

 Score = 69 (29.3 bits), Expect = 2.0e-297, Sum P(8) = 2.0e-297
 Identities = 15/31 (48%), Positives = 17/31 (54%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GE G PG  G+ G  G  GLPG +G  G  G
Sbjct:   309 GESGSPGENGSPGPMGPRGLPGERGRTGPAG 339

 Score = 69 (29.3 bits), Expect = 5.3e-268, Sum P(7) = 5.3e-268
 Identities = 15/32 (46%), Positives = 17/32 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             RG  G  GP G  G+ G  G  G PG+DG  G
Sbjct:   494 RGEPGGAGPIGPPGERGAPGNRGFPGQDGLAG 525

 Score = 69 (29.3 bits), Expect = 5.3e-268, Sum P(7) = 5.3e-268
 Identities = 14/32 (43%), Positives = 17/32 (53%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             GA G  GP+G  G  G  GP G  G+ G  G+
Sbjct:   429 GAPGFPGPRGPPGPQGATGPLGPKGQAGEPGI 460

 Score = 69 (29.3 bits), Expect = 5.2e-266, Sum P(7) = 5.2e-266
 Identities = 14/31 (45%), Positives = 16/31 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G PG  G +G  G PGL G+ G  G  G
Sbjct:   609 GANGEPGKAGEKGLAGAPGLRGLPGKDGETG 639

 Score = 68 (29.0 bits), Expect = 5.4e-299, Sum P(8) = 5.4e-299
 Identities = 15/32 (46%), Positives = 17/32 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             RGA G  G  G  G  G  GP GA G+ G +G
Sbjct:   818 RGAPGERGETGPPGPAGFAGPPGADGQPGAKG 849

 Score = 68 (29.0 bits), Expect = 5.4e-299, Sum P(8) = 5.4e-299
 Identities = 14/33 (42%), Positives = 17/33 (51%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E+G  G  G  G RG  G  GP G  G +G +G
Sbjct:   772 EKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKG 804

 Score = 68 (29.0 bits), Expect = 5.4e-299, Sum P(8) = 5.4e-299
 Identities = 14/33 (42%), Positives = 17/33 (51%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             RG  G  G  G +G  G  GP GA G  G +G+
Sbjct:   719 RGLPGTPGTDGPKGAAGPDGPPGAQGPPGLQGM 751

 Score = 68 (29.0 bits), Expect = 1.2e-291, Sum P(7) = 1.2e-291
 Identities = 14/32 (43%), Positives = 17/32 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +G +G  GP+G  G  G KG  GA G  G  G
Sbjct:   866 QGPSGAPGPQGPTGVTGPKGARGAQGPPGATG 897

 Score = 68 (29.0 bits), Expect = 1.1e-290, Sum P(7) = 1.1e-290
 Identities = 14/31 (45%), Positives = 16/31 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G+ G  G  G+ G  GP G  G  G RG
Sbjct:   624 GAPGLRGLPGKDGETGAAGPPGPSGPAGERG 654

 Score = 68 (29.0 bits), Expect = 3.9e-258, Sum P(7) = 3.9e-258
 Identities = 14/31 (45%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G+ GP G  G+ GE G +G  G DG  G
Sbjct:   942 GDPGLQGPAGAPGEKGEPGDDGPSGLDGPPG 972

 Score = 68 (29.0 bits), Expect = 7.9e-254, Sum P(7) = 7.9e-254
 Identities = 13/25 (52%), Positives = 15/25 (60%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGV 259
             + GE G PG  G  G PG PG PG+
Sbjct:   150 RDGEPGTPGNPGPAGPPGPPGPPGL 174

 Score = 68 (29.0 bits), Expect = 2.0e-247, Sum P(6) = 2.0e-247
 Identities = 14/31 (45%), Positives = 15/31 (48%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G+ GP G  GD G  GP G  G  G  G
Sbjct:  1137 GLQGLPGPPGPSGDQGASGPAGPSGPRGPPG 1167

 Score = 68 (29.0 bits), Expect = 2.0e-247, Sum P(6) = 2.0e-247
 Identities = 16/34 (47%), Positives = 16/34 (47%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             RG  G  GP G  G  G  GP G PG  G  G T
Sbjct:  1163 RGPPGPVGPSGKDGSNGIPGPIGPPGPRGRSGET 1196

 Score = 68 (29.0 bits), Expect = 7.5e-246, Sum P(6) = 7.5e-246
 Identities = 14/31 (45%), Positives = 16/31 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G AG  G  G+ G  G+ G  G PG  G RG
Sbjct:   246 GPAGKPGDDGEAGKPGKSGERGLPGPQGARG 276

 Score = 68 (29.0 bits), Expect = 2.8e-244, Sum P(6) = 2.8e-244
 Identities = 17/35 (48%), Positives = 18/35 (51%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGH---RGFPG 267
             +G  G PGP GA G  G  G PG  G    RG PG
Sbjct:   788 TGPIGPPGPAGANGEKGEVGPPGPSGSTGARGAPG 822

 Score = 68 (29.0 bits), Expect = 5.3e-237, Sum P(5) = 5.3e-237
 Identities = 16/34 (47%), Positives = 18/34 (52%)

Query:   729 GAAGIG---GPKGDRGDVGEKGPEGAPGKDGNRG 759
             G A +G   GP G  G  G  GP GAPG  G +G
Sbjct:   192 GGAQMGVMQGPMGPMGPRGPPGPAGAPGPQGFQG 225

 Score = 68 (29.0 bits), Expect = 1.4e-234, Sum P(5) = 1.4e-234
 Identities = 15/31 (48%), Positives = 16/31 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G PGP G  G  G  G  GV+G  G PG
Sbjct:   909 GANGNPGPAGPPGPAGKDGPKGVRGDSGPPG 939

 Score = 67 (28.6 bits), Expect = 6.9e-299, Sum P(8) = 6.9e-299
 Identities = 14/31 (45%), Positives = 15/31 (48%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GPKG  G  G  G +G PG  G  G
Sbjct:   723 GTPGTDGPKGAAGPDGPPGAQGPPGLQGMPG 753

 Score = 67 (28.6 bits), Expect = 1.6e-266, Sum P(7) = 1.6e-266
 Identities = 15/31 (48%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA GI G  G  G  G  GP+GA G  G +G
Sbjct:   423 GAPGIAGAPGFPGPRGPPGPQGATGPLGPKG 453

 Score = 67 (28.6 bits), Expect = 8.5e-266, Sum P(7) = 8.5e-266
 Identities = 15/32 (46%), Positives = 17/32 (53%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +G  G  GP G RG  G PG  G +G  G PG
Sbjct:   641 AGPPGPSGPAGERGEQGAPGPSGFQGLPGPPG 672

 Score = 67 (28.6 bits), Expect = 5.0e-258, Sum P(7) = 5.0e-258
 Identities = 15/33 (45%), Positives = 15/33 (45%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E G  G  G  GDRG  G  GP G  G  G  G
Sbjct:  1003 EPGKQGAPGASGDRGPPGPVGPPGLTGPAGEPG 1035

 Score = 67 (28.6 bits), Expect = 5.5e-253, Sum P(7) = 5.5e-253
 Identities = 15/33 (45%), Positives = 18/33 (54%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E G  G  G KG RG  G +G  G PG  G++G
Sbjct:  1120 ESGEQGERGLKGHRGFTGLQGLPGPPGPSGDQG 1152

 Score = 67 (28.6 bits), Expect = 5.9e-238, Sum P(5) = 5.9e-238
 Identities = 14/31 (45%), Positives = 16/31 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G+ G  G QG  G  G  G PG +G  G PG
Sbjct:   843 GQPGAKGDQGEAGQKGDAGAPGPQGPSGAPG 873

 Score = 67 (28.6 bits), Expect = 1.2e-212, Sum P(6) = 1.2e-212
 Identities = 15/31 (48%), Positives = 15/31 (48%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G PG QG  G PG  G PG  G  G  G
Sbjct:   939 GRAGDPGLQGPAGAPGEKGEPGDDGPSGLDG 969

 Score = 66 (28.3 bits), Expect = 8.8e-299, Sum P(8) = 8.8e-299
 Identities = 14/31 (45%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GP G +G  GE+G  G  G  G+RG
Sbjct:   738 GPPGAQGPPGLQGMPGERGAAGIAGPKGDRG 768

 Score = 66 (28.3 bits), Expect = 8.8e-299, Sum P(8) = 8.8e-299
 Identities = 16/36 (44%), Positives = 18/36 (50%)

Query:   727 ERGAAGIGGPKGD---RGDVGEKGPEGAPGKDGNRG 759
             E+G  G  GP G    RG  GE+G  G PG  G  G
Sbjct:   802 EKGEVGPPGPSGSTGARGAPGERGETGPPGPAGFAG 837

 Score = 66 (28.3 bits), Expect = 2.0e-291, Sum P(7) = 2.0e-291
 Identities = 14/31 (45%), Positives = 16/31 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G  GP G  G  G+ GP+G  G  G  G
Sbjct:   909 GANGNPGPAGPPGPAGKDGPKGVRGDSGPPG 939

 Score = 66 (28.3 bits), Expect = 1.8e-290, Sum P(7) = 1.8e-290
 Identities = 15/33 (45%), Positives = 17/33 (51%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E+G AG  G +G  G  GE G  G PG  G  G
Sbjct:   619 EKGLAGAPGLRGLPGKDGETGAAGPPGPSGPAG 651

 Score = 66 (28.3 bits), Expect = 1.1e-267, Sum P(7) = 1.1e-267
 Identities = 14/31 (45%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GP+G  G +G KG  G PG  G +G
Sbjct:   435 GPRGPPGPQGATGPLGPKGQAGEPGIAGFKG 465

 Score = 66 (28.3 bits), Expect = 1.8e-256, Sum P(6) = 1.8e-256
 Identities = 15/32 (46%), Positives = 16/32 (50%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             RG  G  GP G  G VG  G  G PG  G +G
Sbjct:   344 RGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKG 375

 Score = 66 (28.3 bits), Expect = 3.7e-248, Sum P(6) = 3.7e-248
 Identities = 13/31 (41%), Positives = 16/31 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G  GP G +G PG  G  G+ G +G  G
Sbjct:   738 GPPGAQGPPGLQGMPGERGAAGIAGPKGDRG 768

 Score = 66 (28.3 bits), Expect = 3.7e-248, Sum P(6) = 3.7e-248
 Identities = 17/33 (51%), Positives = 17/33 (51%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             K G RGL GP G    PG  G  G KG  G PG
Sbjct:   781 KDGGRGLTGPIGP---PGPAGANGEKGEVGPPG 810

 Score = 66 (28.3 bits), Expect = 3.7e-248, Sum P(6) = 3.7e-248
 Identities = 14/33 (42%), Positives = 15/33 (45%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             + G  G PG  G RG  G  G PG  G  G  G
Sbjct:   772 EKGPEGAPGKDGGRGLTGPIGPPGPAGANGEKG 804

 Score = 66 (28.3 bits), Expect = 1.4e-234, Sum P(5) = 1.4e-234
 Identities = 15/32 (46%), Positives = 16/32 (50%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             G  G  GP GA G PG  G PG  G  G  G+
Sbjct:   900 GAAGRVGPPGANGNPGPAGPPGPAGKDGPKGV 931

 Score = 66 (28.3 bits), Expect = 3.5e-202, Sum P(5) = 3.5e-202
 Identities = 15/32 (46%), Positives = 17/32 (53%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +G +G  G  GA G PG PG PG  G  G  G
Sbjct:  1052 AGVKGDRGETGALGAPGAPGPPGSPGPAGPTG 1083

 Score = 65 (27.9 bits), Expect = 1.1e-298, Sum P(8) = 1.1e-298
 Identities = 13/31 (41%), Positives = 16/31 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GP G  G  G  G +G PG  G++G
Sbjct:   822 GERGETGPPGPAGFAGPPGADGQPGAKGDQG 852

 Score = 65 (27.9 bits), Expect = 1.1e-298, Sum P(8) = 1.1e-298
 Identities = 14/31 (45%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G  G +G  G +G  GP GA G+ G  G
Sbjct:   777 GAPGKDGGRGLTGPIGPPGPAGANGEKGEVG 807

 Score = 65 (27.9 bits), Expect = 1.4e-267, Sum P(7) = 1.4e-267
 Identities = 14/32 (43%), Positives = 16/32 (50%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             RG  G  G  G +G  GE+GP G  G  G  G
Sbjct:   515 RGFPGQDGLAGPKGAPGERGPSGLTGPKGANG 546

 Score = 65 (27.9 bits), Expect = 1.4e-267, Sum P(7) = 1.4e-267
 Identities = 14/33 (42%), Positives = 15/33 (45%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E G  G  G  G  G +G  G  GAPG  G  G
Sbjct:   487 EEGKRGARGEPGGAGPIGPPGERGAPGNRGFPG 519

 Score = 65 (27.9 bits), Expect = 4.1e-247, Sum P(6) = 4.1e-247
 Identities = 14/31 (45%), Positives = 17/31 (54%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G AG  GP+G  G VG  G +G+ G  G  G
Sbjct:  1155 GPAGPSGPRGPPGPVGPSGKDGSNGIPGPIG 1185

 Score = 65 (27.9 bits), Expect = 1.0e-200, Sum P(5) = 1.0e-200
 Identities = 15/31 (48%), Positives = 17/31 (54%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GE G  G  GA G PG+PG  G  G +G  G
Sbjct:  1059 GETGALGAPGAPGPPGSPGPAGPTGKQGDRG 1089

 Score = 65 (27.9 bits), Expect = 3.0e-197, Sum P(5) = 3.0e-197
 Identities = 14/31 (45%), Positives = 16/31 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             GE G  GP G  G  G  G+ G +G RG  G
Sbjct:  1089 GEAGAQGPMGPSGPAGARGIAGPQGPRGDKG 1119

 Score = 64 (27.6 bits), Expect = 3.2e-291, Sum P(7) = 3.2e-291
 Identities = 14/31 (45%), Positives = 16/31 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G  GP G  G  G +G +G PG  G  G
Sbjct:   870 GAPGPQGPTGVTGPKGARGAQGPPGATGFPG 900

 Score = 64 (27.6 bits), Expect = 3.2e-291, Sum P(7) = 3.2e-291
 Identities = 14/33 (42%), Positives = 16/33 (48%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             G  G  G  G +G  G  GP+GA G  G  G T
Sbjct:   864 GPQGPSGAPGPQGPTGVTGPKGARGAQGPPGAT 896

 Score = 64 (27.6 bits), Expect = 2.8e-290, Sum P(7) = 2.8e-290
 Identities = 12/31 (38%), Positives = 16/31 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G+ G  G+ G  G  GP G  G+ G +G
Sbjct:   627 GLRGLPGKDGETGAAGPPGPSGPAGERGEQG 657

 Score = 64 (27.6 bits), Expect = 2.9e-256, Sum P(6) = 2.9e-256
 Identities = 15/33 (45%), Positives = 15/33 (45%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGLT 761
             G  G  GP G  G  G  G  GAPG  G  G T
Sbjct:   348 GQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPT 380

 Score = 64 (27.6 bits), Expect = 5.9e-248, Sum P(6) = 5.9e-248
 Identities = 16/36 (44%), Positives = 19/36 (52%)

Query:   237 GERGLPGPQGARGFPGTPGLPG---VKGHRGFPGLD 269
             G +G+PG +GA G  G  G  G    KG  G PG D
Sbjct:   747 GLQGMPGERGAAGIAGPKGDRGDVGEKGPEGAPGKD 782

 Score = 64 (27.6 bits), Expect = 5.2e-247, Sum P(6) = 5.2e-247
 Identities = 13/26 (50%), Positives = 14/26 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPG 753
             RG +G  GP G  G  G  GP G PG
Sbjct:  1190 RGRSGETGPVGPPGSPGPPGPPGPPG 1215

 Score = 64 (27.6 bits), Expect = 3.1e-214, Sum P(6) = 3.1e-214
 Identities = 14/31 (45%), Positives = 15/31 (48%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G+ G PG  G  G  G  G PG KG  G  G
Sbjct:   933 GDSGPPGRAGDPGLQGPAGAPGEKGEPGDDG 963

 Score = 64 (27.6 bits), Expect = 6.3e-203, Sum P(5) = 6.3e-203
 Identities = 14/32 (43%), Positives = 16/32 (50%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             G  GL GP G  G  G+PG  G  G  G  G+
Sbjct:  1023 GPPGLTGPAGEPGREGSPGADGPPGRDGAAGV 1054

 Score = 63 (27.2 bits), Expect = 1.8e-298, Sum P(8) = 1.8e-298
 Identities = 13/32 (40%), Positives = 16/32 (50%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G  G  GP G  G  G  G +G PG+ G  G+
Sbjct:   729 GPKGAAGPDGPPGAQGPPGLQGMPGERGAAGI 760

 Score = 63 (27.2 bits), Expect = 8.7e-297, Sum P(8) = 8.7e-297
 Identities = 14/31 (45%), Positives = 16/31 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G PG +G  G  G  G  G +G RG PG
Sbjct:   366 GFPGAPGAKGEAGPTGARGPEGAQGSRGEPG 396

 Score = 63 (27.2 bits), Expect = 1.4e-252, Sum P(7) = 1.4e-252
 Identities = 17/44 (38%), Positives = 22/44 (50%)

Query:   728 RGAAGIGGPKGDRGDVGEKGP------------EGAPGKDGNRG 759
             RG AG  GP+GD+G+ GE+G             +G PG  G  G
Sbjct:  1106 RGIAGPQGPRGDKGESGEQGERGLKGHRGFTGLQGLPGPPGPSG 1149

 Score = 63 (27.2 bits), Expect = 2.5e-245, Sum P(6) = 2.5e-245
 Identities = 16/34 (47%), Positives = 17/34 (50%)

Query:   729 GAAGIGGPKGDRGDVG---EKGPEGAPGKDGNRG 759
             G  G+ G KG RG  G    KG  GAPG  G  G
Sbjct:   279 GTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESG 312

 Score = 63 (27.2 bits), Expect = 1.8e-236, Sum P(5) = 1.8e-236
 Identities = 14/37 (37%), Positives = 20/37 (54%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGA---PGKDGNRGLT 761
             +G  G  GP+G  G  G  GP+G    PG+ G  G++
Sbjct:   200 QGPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVS 236

 Score = 63 (27.2 bits), Expect = 1.2e-229, Sum P(4) = 1.2e-229
 Identities = 15/32 (46%), Positives = 15/32 (46%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPGL 268
             G  G PGP G  G  G  G  G  G  G PGL
Sbjct:   915 GPAGPPGPAGKDGPKGVRGDSGPPGRAGDPGL 946

 Score = 63 (27.2 bits), Expect = 8.1e-203, Sum P(5) = 8.1e-203
 Identities = 14/31 (45%), Positives = 15/31 (48%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G  G +G RG  G  G PG  G  G PG
Sbjct:  1047 GRDGAAGVKGDRGETGALGAPGAPGPPGSPG 1077

 Score = 62 (26.9 bits), Expect = 5.2e-291, Sum P(7) = 5.2e-291
 Identities = 15/32 (46%), Positives = 15/32 (46%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             RGA G  G  G  G  G  GP GA G  G  G
Sbjct:   887 RGAQGPPGATGFPGAAGRVGPPGANGNPGPAG 918

 Score = 62 (26.9 bits), Expect = 4.6e-290, Sum P(7) = 4.6e-290
 Identities = 13/32 (40%), Positives = 17/32 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +G  G  G  G+ G  G  GP+GA G+ G  G
Sbjct:   572 QGKVGPSGAPGEDGRPGPPGPQGARGQPGVMG 603

 Score = 62 (26.9 bits), Expect = 2.9e-267, Sum P(7) = 2.9e-267
 Identities = 14/32 (43%), Positives = 17/32 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +GA G  GPKG  G+ G  G +G  G  G  G
Sbjct:   443 QGATGPLGPKGQAGEPGIAGFKGDQGPKGETG 474

 Score = 62 (26.9 bits), Expect = 5.2e-266, Sum P(7) = 5.2e-266
 Identities = 14/31 (45%), Positives = 14/31 (45%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G  G  G  G  G  GP G PG  G  G
Sbjct:   417 GAKGSAGAPGIAGAPGFPGPRGPPGPQGATG 447

 Score = 62 (26.9 bits), Expect = 1.2e-256, Sum P(7) = 1.2e-256
 Identities = 13/31 (41%), Positives = 16/31 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G  GP G  G  G  G +G  G+ G +G
Sbjct:  1065 GAPGAPGPPGSPGPAGPTGKQGDRGEAGAQG 1095

 Score = 62 (26.9 bits), Expect = 9.6e-248, Sum P(6) = 9.6e-248
 Identities = 16/34 (47%), Positives = 18/34 (52%)

Query:   237 GERGLPGPQGARGFPGT--P-GLPGVKGHRGFPG 267
             G  G+ GP+G RG  G   P G PG  G RG  G
Sbjct:   756 GAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTG 789

 Score = 62 (26.9 bits), Expect = 3.2e-245, Sum P(6) = 3.2e-245
 Identities = 14/32 (43%), Positives = 17/32 (53%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G AG  G  G+RG  G +G  G PG  G  G+
Sbjct:   255 GEAGKPGKSGERGLPGPQGARGFPGTPGLPGV 286

 Score = 62 (26.9 bits), Expect = 3.2e-245, Sum P(6) = 3.2e-245
 Identities = 16/37 (43%), Positives = 19/37 (51%)

Query:   729 GAAGIGGPKGDRGDVGE------KGPEGAPGKDGNRG 759
             G  G+ GP+G RG  G       KG  G PG DG +G
Sbjct:   264 GERGLPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKG 300

 Score = 61 (26.5 bits), Expect = 3.7e-267, Sum P(7) = 3.7e-267
 Identities = 13/31 (41%), Positives = 16/31 (51%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GP G +G  G  GP+G  G+ G  G
Sbjct:   432 GFPGPRGPPGPQGATGPLGPKGQAGEPGIAG 462

 Score = 61 (26.5 bits), Expect = 6.7e-266, Sum P(7) = 6.7e-266
 Identities = 14/31 (45%), Positives = 15/31 (48%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  G  G +G  G  G  GAPG  G RG
Sbjct:   408 GNPGTDGIPGAKGSAGAPGIAGAPGFPGPRG 438

 Score = 61 (26.5 bits), Expect = 6.7e-266, Sum P(7) = 6.7e-266
 Identities = 15/31 (48%), Positives = 15/31 (48%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G AG  G  G  G  G KG  GAPG  G  G
Sbjct:   402 GPAGASGNPGTDGIPGAKGSAGAPGIAGAPG 432

 Score = 61 (26.5 bits), Expect = 1.2e-247, Sum P(6) = 1.2e-247
 Identities = 14/31 (45%), Positives = 17/31 (54%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G+RG  G +G  G PG  G  G+ G  G PG
Sbjct:   765 GDRGDVGEKGPEGAPGKDGGRGLTGPIGPPG 795

 Score = 61 (26.5 bits), Expect = 2.9e-236, Sum P(5) = 2.9e-236
 Identities = 13/32 (40%), Positives = 17/32 (53%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             +G  G  G  G  G +G +GP G  GK G+ G
Sbjct:   224 QGNPGEPGEPGVSGPMGPRGPPGPAGKPGDDG 255

 Score = 61 (26.5 bits), Expect = 1.3e-202, Sum P(5) = 1.3e-202
 Identities = 13/33 (39%), Positives = 16/33 (48%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             + G  G+ G +G  G  G PG PG  G  G  G
Sbjct:  1048 RDGAAGVKGDRGETGALGAPGAPGPPGSPGPAG 1080

 Score = 61 (26.5 bits), Expect = 7.9e-197, Sum P(5) = 7.9e-197
 Identities = 13/30 (43%), Positives = 16/30 (53%)

Query:   235 KSGERGLPGPQGARGFPGTPGLPGVKGHRG 264
             K G+RG  G QG  G  G  G  G+ G +G
Sbjct:  1084 KQGDRGEAGAQGPMGPSGPAGARGIAGPQG 1113

 Score = 61 (26.5 bits), Expect = 4.8e-147, Sum P(3) = 4.8e-147
 Identities = 11/24 (45%), Positives = 13/24 (54%)

Query:  1008 GREGNPGADGPPGRDGSAGVKGDR 1031
             G  G PG  GP G  G  G +GD+
Sbjct:   116 GPRGPPGPQGPAGEQGPRGDRGDK 139

 Score = 60 (26.2 bits), Expect = 3.9e-272, Sum P(8) = 3.9e-272
 Identities = 19/63 (30%), Positives = 21/63 (33%)

Query:   911 TGRAGDPGLQGPAGAPGEKXXXXXXXXXXXXXXXXXXXXXXXXXIVGLPGQRGERGFPGL 970
             +G AG  G +GP G  G                            VG PG  G  G PG 
Sbjct:  1154 SGPAGPSGPRGPPGPVGPSGKDGSNGIPGPIGPPGPRGRSGETGPVGPPGSPGPPGPPGP 1213

Query:   971 PGP 973
             PGP
Sbjct:  1214 PGP 1216

 Score = 60 (26.2 bits), Expect = 8.5e-266, Sum P(7) = 8.5e-266
 Identities = 13/32 (40%), Positives = 15/32 (46%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             RG  G  G  G  G  G  G +G PG  G+ G
Sbjct:   392 RGEPGNPGSPGPAGASGNPGTDGIPGAKGSAG 423

 Score = 60 (26.2 bits), Expect = 1.6e-263, Sum P(8) = 1.6e-263
 Identities = 14/39 (35%), Positives = 17/39 (43%)

Query:    88 VVGPRGPLGPQGPSGEQXXXXXXXX--XXXXXXTPGPRG 124
             V GP GP GP GP+G+                  PGP+G
Sbjct:   235 VSGPMGPRGPPGPAGKPGDDGEAGKPGKSGERGLPGPQG 273

 Score = 60 (26.2 bits), Expect = 7.7e-256, Sum P(6) = 7.7e-256
 Identities = 14/31 (45%), Positives = 14/31 (45%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GA G  G  G  G  G  GP G PG  G  G
Sbjct:   342 GARGNDGQPGPAGPPGPVGPAGGPGFPGAPG 372

 Score = 60 (26.2 bits), Expect = 2.3e-156, Sum P(4) = 2.3e-156
 Identities = 10/19 (52%), Positives = 14/19 (73%)

Query:    86 KDVVGPRGPLGPQGPSGEQ 104
             + + GP+GP G +G SGEQ
Sbjct:  1106 RGIAGPQGPRGDKGESGEQ 1124

 Score = 59 (25.8 bits), Expect = 7.2e-273, Sum P(8) = 7.2e-273
 Identities = 9/13 (69%), Positives = 11/13 (84%)

Query:    90 GPRGPLGPQGPSG 102
             GP GP+GP+GP G
Sbjct:   201 GPMGPMGPRGPPG 213

 Score = 59 (25.8 bits), Expect = 3.2e-262, Sum P(7) = 3.2e-262
 Identities = 14/37 (37%), Positives = 18/37 (48%)

Query:   524 PGEPGLPGARGLTGRPGDAG---------PQGKLGPS 551
             PG  G PG +G  G PG+ G         P+G  GP+
Sbjct:   212 PGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPA 248

 Score = 59 (25.8 bits), Expect = 6.6e-245, Sum P(6) = 6.6e-245
 Identities = 14/32 (43%), Positives = 16/32 (50%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             G  G  G  G  G+ G  GP+GA G  G  GL
Sbjct:   252 GDDGEAGKPGKSGERGLPGPQGARGFPGTPGL 283

 Score = 59 (25.8 bits), Expect = 4.4e-200, Sum P(5) = 4.4e-200
 Identities = 13/31 (41%), Positives = 15/31 (48%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G PGP G+ G  G  G  G +G  G  G
Sbjct:  1065 GAPGAPGPPGSPGPAGPTGKQGDRGEAGAQG 1095

 Score = 58 (25.5 bits), Expect = 6.4e-272, Sum P(8) = 6.4e-272
 Identities = 13/32 (40%), Positives = 16/32 (50%)

Query:   236 SGERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             +G +G  GP+G  G  G  G PG  G  G  G
Sbjct:   461 AGFKGDQGPKGETGPAGPQGAPGPAGEEGKRG 492

 Score = 58 (25.5 bits), Expect = 1.3e-255, Sum P(6) = 1.3e-255
 Identities = 14/31 (45%), Positives = 14/31 (45%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             GAAG  G  G  G  G  GP G  G  G  G
Sbjct:   339 GAAGARGNDGQPGPAGPPGPVGPAGGPGFPG 369

 Score = 58 (25.5 bits), Expect = 8.8e-253, Sum P(7) = 8.8e-253
 Identities = 10/13 (76%), Positives = 11/13 (84%)

Query:    90 GPRGPLGPQGPSG 102
             GPRGP GPQG +G
Sbjct:   435 GPRGPPGPQGATG 447

 Score = 57 (25.1 bits), Expect = 6.5e-292, Sum P(9) = 6.5e-292
 Identities = 11/19 (57%), Positives = 12/19 (63%)

Query:   425 KGQTGEPGIAGFKGEQGPK 443
             KG  G PGIAG  G  GP+
Sbjct:   419 KGSAGAPGIAGAPGFPGPR 437

 Score = 57 (25.1 bits), Expect = 1.5e-289, Sum P(7) = 1.5e-289
 Identities = 13/31 (41%), Positives = 15/31 (48%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GP G +G  G+ G  G PG  G  G
Sbjct:   582 GEDGRPGPPGPQGARGQPGVMGFPGPKGANG 612

 Score = 57 (25.1 bits), Expect = 1.8e-265, Sum P(7) = 1.8e-265
 Identities = 14/31 (45%), Positives = 14/31 (45%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  GI G KG  G  G  G  G PG  G  G
Sbjct:   411 GTDGIPGAKGSAGAPGIAGAPGFPGPRGPPG 441

 Score = 57 (25.1 bits), Expect = 1.8e-265, Sum P(7) = 1.8e-265
 Identities = 14/34 (41%), Positives = 16/34 (47%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRGL 760
             E G  G  GP G  G+ G  G  GA G  G  G+
Sbjct:   394 EPGNPGSPGPAGASGNPGTDGIPGAKGSAGAPGI 427

 Score = 57 (25.1 bits), Expect = 1.6e-255, Sum P(6) = 1.6e-255
 Identities = 13/32 (40%), Positives = 15/32 (46%)

Query:   728 RGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             RG  G  G  G  G  G +G +G PG  G  G
Sbjct:   326 RGLPGERGRTGPAGAAGARGNDGQPGPAGPPG 357

 Score = 56 (24.8 bits), Expect = 1.5e-272, Sum P(8) = 1.5e-272
 Identities = 9/14 (64%), Positives = 11/14 (78%)

Query:    89 VGPRGPLGPQGPSG 102
             +GP GP GP GP+G
Sbjct:   203 MGPMGPRGPPGPAG 216

 Score = 56 (24.8 bits), Expect = 3.6e-246, Sum P(6) = 3.6e-246
 Identities = 12/31 (38%), Positives = 15/31 (48%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G +G  G  G  G +G  GP G  G+ G  G
Sbjct:  1170 GPSGKDGSNGIPGPIGPPGPRGRSGETGPVG 1200

 Score = 56 (24.8 bits), Expect = 1.4e-244, Sum P(6) = 1.4e-244
 Identities = 13/33 (39%), Positives = 16/33 (48%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             E G  G  G +G  G  G +G  G PG  G +G
Sbjct:   256 EAGKPGKSGERGLPGPQGARGFPGTPGLPGVKG 288

 Score = 56 (24.8 bits), Expect = 9.2e-238, Sum P(8) = 9.2e-238
 Identities = 10/19 (52%), Positives = 12/19 (63%)

Query:    86 KDVVGPRGPLGPQGPSGEQ 104
             K   GP GP G  GP+GE+
Sbjct:   470 KGETGPAGPQGAPGPAGEE 488

 Score = 55 (24.4 bits), Expect = 1.9e-272, Sum P(8) = 1.9e-272
 Identities = 10/16 (62%), Positives = 11/16 (68%)

Query:    89 VGPRGPLGPQGPSGEQ 104
             +GPRGP GP G  G Q
Sbjct:   206 MGPRGPPGPAGAPGPQ 221

 Score = 55 (24.4 bits), Expect = 1.9e-256, Sum P(7) = 1.9e-256
 Identities = 10/15 (66%), Positives = 11/15 (73%)

Query:   653 SGDQGVPGEAGAPGL 667
             SGD+G PG  G PGL
Sbjct:  1013 SGDRGPPGPVGPPGL 1027

 Score = 55 (24.4 bits), Expect = 1.2e-235, Sum P(5) = 1.2e-235
 Identities = 13/31 (41%), Positives = 15/31 (48%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GP G  G  G +G  G PG+ G  G
Sbjct:   207 GPRGPPGPAGAPGPQGFQGNPGEPGEPGVSG 237

 Score = 55 (24.4 bits), Expect = 2.2e-210, Sum P(5) = 2.2e-210
 Identities = 11/19 (57%), Positives = 11/19 (57%)

Query:    86 KDVVGPRGPLGPQGPSGEQ 104
             K   GP GP G QGP G Q
Sbjct:   731 KGAAGPDGPPGAQGPPGLQ 749

 Score = 54 (24.1 bits), Expect = 1.6e-297, Sum P(8) = 1.6e-297
 Identities = 12/31 (38%), Positives = 14/31 (45%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  GP G  G  G +G  G  G+ G  G
Sbjct:   801 GEKGEVGPPGPSGSTGARGAPGERGETGPPG 831

 Score = 54 (24.1 bits), Expect = 5.0e-282, Sum P(6) = 5.0e-282
 Identities = 10/14 (71%), Positives = 10/14 (71%)

Query:   654 GDQGVPGEAGAPGL 667
             GD G PG AG PGL
Sbjct:   933 GDSGPPGRAGDPGL 946

 Score = 54 (24.1 bits), Expect = 1.6e-235, Sum P(5) = 1.6e-235
 Identities = 12/31 (38%), Positives = 14/31 (45%)

Query:   729 GAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             G  G  G  G+ G+ G  GP G  G  G  G
Sbjct:   219 GPQGFQGNPGEPGEPGVSGPMGPRGPPGPAG 249

 Score = 54 (24.1 bits), Expect = 4.6e-221, Sum P(6) = 4.6e-221
 Identities = 10/15 (66%), Positives = 10/15 (66%)

Query:    90 GPRGPLGPQGPSGEQ 104
             GP GP GP G  GEQ
Sbjct:   642 GPPGPSGPAGERGEQ 656

 Score = 54 (24.1 bits), Expect = 2.8e-210, Sum P(5) = 2.8e-210
 Identities = 9/15 (60%), Positives = 10/15 (66%)

Query:    90 GPRGPLGPQGPSGEQ 104
             GP+G  GP GP G Q
Sbjct:   729 GPKGAAGPDGPPGAQ 743

 Score = 54 (24.1 bits), Expect = 1.5e-199, Sum P(5) = 1.5e-199
 Identities = 13/31 (41%), Positives = 14/31 (45%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G  G PGP G  G  G  G  G +G  G  G
Sbjct:  1071 GPPGSPGPAGPTGKQGDRGEAGAQGPMGPSG 1101

 Score = 54 (24.1 bits), Expect = 4.7e-158, Sum P(4) = 4.7e-158
 Identities = 8/13 (61%), Positives = 11/13 (84%)

Query:    90 GPRGPLGPQGPSG 102
             G +GP+GP GP+G
Sbjct:  1092 GAQGPMGPSGPAG 1104

 Score = 54 (24.1 bits), Expect = 2.1e-142, Sum P(2) = 2.1e-142
 Identities = 10/16 (62%), Positives = 12/16 (75%)

Query:    88 VVGPRGPLGPQGPSGE 103
             + GP GP GP+G SGE
Sbjct:  1180 IPGPIGPPGPRGRSGE 1195

 Score = 53 (23.7 bits), Expect = 8.4e-263, Sum P(8) = 8.4e-263
 Identities = 9/13 (69%), Positives = 10/13 (76%)

Query:    90 GPRGPLGPQGPSG 102
             GP GP GP GP+G
Sbjct:   351 GPAGPPGPVGPAG 363

 Score = 53 (23.7 bits), Expect = 1.6e-251, Sum P(7) = 1.6e-251
 Identities = 14/33 (42%), Positives = 15/33 (45%)

Query:   727 ERGAAGIGGPKGDRGDVGEKGPEGAPGKDGNRG 759
             ERG  G  G  G +G  G  GP G  G  G  G
Sbjct:  1126 ERGLKGHRGFTGLQGLPGPPGPSGDQGASGPAG 1158

 Score = 53 (23.7 bits), Expect = 8.5e-247, Sum P(6) = 8.5e-247
 Identities = 14/31 (45%), Positives = 16/31 (51%)

Query:   237 GERGLPGPQGARGFPGTPGLPGVKGHRGFPG 267
             G+ G  GP+GA G  G  GL G  G  G  G
Sbjct:   768 GDVGEKGPEGAPGKDGGRGLTGPIGPPGPAG 798

 Score = 53 (23.7 bits), Expect = 2.4e-201, Sum P(5) = 2.4e-201
 Identities = 13/41 (31%), Positives = 17/41 (41%)

Query:    86 KDVVGPRGPLGPQGPSGEQXXXX--XXXXXXXXXXTPGPRG 124
             + + GP GP GP G +GE+                 PG RG
Sbjct:   785 RGLTGPIGPPGPAGANGEKGEVGPPGPSGSTGARGAPGERG 825

 Score = 52 (23.4 bits), Expect = 3.6e-282, Sum P(9) = 3.6e-282
 Identities = 10/17 (58%), Positives = 11/17 (64%)

Query:   425 KGQTGEPGIAGFKGEQG 441
             KG  G PG+ G KGE G
Sbjct:   287 KGHRGYPGLDGAKGEAG 303

 Score = 52 (23.4 bits), Expect = 8.2e-282, Sum P(6) = 8.2e-282
 Identities = 9/15 (60%), Positives = 12/15 (80%)

Query:   652 KSGDQGVPGEAGAPG 666
             ++GD G+ G AGAPG
Sbjct:   940 RAGDPGLQGPAGAPG 954

 Score = 52 (23.4 bits), Expect = 3.8e-252, Sum P(7) = 3.8e-252
 Identities = 9/14 (64%), Positives = 11/14 (78%)

Query:    90 GPRGPLGPQGPSGE 103
             G  GPLGP+G +GE
Sbjct:   444 GATGPLGPKGQAGE 457

 Score = 52 (23.4 bits), Expect = 8.6e-222, Sum P(6) = 8.6e-222
 Identities = 10/17 (58%), Positives = 12/17 (70%)

Query:  1091 KGEAGEAGERGLKGHRG 1107
             KG+AGE G  G KG +G
Sbjct:   452 KGQAGEPGIAGFKGDQG 468

 Score = 52 (23.4 bits), Expect = 2.1e-200, Sum P(5) = 2.1e-200
 Identities = 9/13 (69%), Positives = 10/13 (76%)

Query:    90 GPRGPLGPQGPSG 102
             GP G  GPQGP+G
Sbjct:   867 GPSGAPGPQGPTG 879

 Score = 51 (23.0 bits), Expect = 3.5e-307, Sum P(8) = 3.5e-307
 Identities = 8/13 (61%), Positives = 11/13 (84%)

Query:   654 GDQGVPGEAGAPG 666
             G++G PGE G+PG
Sbjct:   699 GERGFPGERGSPG 711

 Score = 51 (23.0 bits), Expect = 4.2e-265, Sum P(8) = 4.2e-265
 Identities = 9/18 (50%), Positives = 13/18 (72%)

Query:  1090 DKGEAGEAGERGLKGHRG 1107
             D+GEAG+ G+ G  G +G
Sbjct:   850 DQGEAGQKGDAGAPGPQG 867

 Score = 51 (23.0 bits), Expect = 2.5e-243, Sum P(6) = 2.5e-243
 Identities = 10/16 (62%), Positives = 12/16 (75%)

Query:  1092 GEAGEAGERGLKGHRG 1107
             GE G+AGE+GL G  G
Sbjct:   612 GEPGKAGEKGLAGAPG 627

 Score = 51 (23.0 bits), Expect = 2.1e-198, Sum P(5) = 2.1e-198
 Identities = 9/18 (50%), Positives = 14/18 (77%)

Query:  1090 DKGEAGEAGERGLKGHRG 1107
             + G+ G++GERGL G +G
Sbjct:   256 EAGKPGKSGERGLPGPQG 273

 Score = 51 (23.0 bits), Expect = 9.7e-158, Sum P(4) = 9.7e-158
 Identities = 9/15 (60%), Positives = 11/15 (73%)

Query:    90 GPRGPLGPQGPSGEQ 104
             GP G  GP GP+G+Q
Sbjct:  1071 GPPGSPGPAGPTGKQ 1085

 Score = 51 (23.0 bits), Expect = 1.2e-155, Sum P(4) = 1.2e-155
 Identities = 9/15 (60%), Positives = 11/15 (73%)

Query:    90 GPRGPLGPQGPSGEQ 104
             G RG  GPQGP G++
Sbjct:  1104 GARGIAGPQGPRGDK 1118

 Score = 50 (22.7 bits), Expect = 2.7e-284, Sum P(8) = 2.7e-284
 Identities = 9/14 (64%), Positives = 10/14 (71%)

Query:   653 SGDQGVPGEAGAPG 666
             +GD G PGE G PG
Sbjct:   545 NGDPGRPGEPGLPG 558

 Score = 50 (22.7 bits), Expect = 6.4e-272, Sum P(8) = 6.4e-272
 Identities = 8/13 (61%), Positives = 10/13 (76%)

Query:    90 GPRGPLGPQGPSG 102
             G  GP+GP+GP G
Sbjct:   234 GVSGPMGPRGPPG 246

 Score = 50 (22.7 bits), Expect = 3.9e-237, Sum P(8) = 3.9e-237
 Identities = 8/13 (61%), Positives = 9/13 (69%)

Query:    90 GPRGPLGPQGPSG 102
             GP+G  GP GP G
Sbjct:   468 GPKGETGPAGPQG 480